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Prognostic Role of Nucleophosmin in Colorectal Carcinomas

  • Yang, Yu-Feng (Department of Pathology, Dongguan Shilong People's Hospital) ;
  • Zhang, Xi-Ying (Endoscopy Center, Dongguan Shilong People's Hospital) ;
  • Yang, Mei (Department of Gastroenterology, Dongguan Shilong People's Hospital) ;
  • He, Ze-Hua (Department of Surgical Oncology, the Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Peng, Ning-Fu (Department of Surgical Oncology, the Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Xie, Shu-Rui (Department of Pathology, Dongguan Shilong People's Hospital) ;
  • Xie, Yan-Fang (Department of Pathology, Dongguan Shilong People's Hospital)
  • Published : 2014.03.01

Abstract

Aim: Recent research suggests that nucleophosmin (NPM) may be a prognostic marker in colorectal carcinomas (CRC). We here tested its use to predict the survival of CRC patients. Methods: We investigated NPM expression by immunohistochemistry in histologically normal to malignant colorectal tissues and evaluated its association with clinicopathological variables. Overall and disease-free survival after tumor removal were calculated by the Kaplan-Meier method, and differences in survival curves were analyzed by the log-rank test. The Cox proportional hazards model was used for multivariate analysis of prognostic factors. Results: NPM expression was found significantly upregulated in CRC compared to adjacent colorectal tissue, villous adenoma, tubular adenoma and normal colorectal mucosa (p<0.05 for all). NPM expression was statistically linked to cancer embolus, lymph node metastasis, differentiation grade, and recurrence of CRC. Overall and disease-free survival of NPM-negative CRC patients tended to be better than those for patients with NPM-positive lesions (log-rank statistic, p<0.05 for all). Multivariate analysis indicated NPM expression as an independent prognostic indicator for CRC patients (p<0.05 ). Conclusion: Our results suggest that NPM expression can predict the survival of CRC patients. Prognosis of CRC is determined by not only many known prognostic factors but also by NPM expression.

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