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Prevalence and Age, Gender and Geographical Area Distribution of Esophageal Squamous Cell Carcinomas in North China from 1985 to 2006

  • Feng, Xiao-Shan (Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology) ;
  • Yang, Yan-Tong (Cancer Institute, Henan University of Science and Technology) ;
  • Gao, She-Gan (Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology) ;
  • Ru, Yi (Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology) ;
  • Wang, Gong-Ping (Cancer Institute, Henan University of Science and Technology) ;
  • Zhou, Bo (Cancer Institute, Henan University of Science and Technology) ;
  • Wang, Yu-Feng (Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology) ;
  • Zhang, Peng-Fei (Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology) ;
  • Li, Pu-Yu (Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology) ;
  • Liu, Yong-Xuan (Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology)
  • Published : 2014.03.01

Abstract

Objective: To establish the prevalence and distribution profile of esophageal squamous cell carcinomas (ESCCs) over a 22-yr period in North China. Methods: Using endoscopy for primary diagnosis and histological analysis for the further confirmation, a total of 74,854 ESCC patients aged 20-89 between January 1985 and December 2006 were investigated to analyze the epidemiological profile including prevalence rates, distribution of age-of-onset, gender and geographical area of ESCC in Luoyang, the highest incidence area of North China. Results: A total of 4092 cases of ESCC were finally diagnosed among 74,854 patients who had their first endoscopies. The prevalence among males was higher than that among females (p<0.01), resulting in an overall male:female OR of 1.2 (95%CI, 1.2-1.3). The prevalence in rural areas was higher than in urban areas (p<0.01), resulting in an overall rural:urban OR of 2.6 (95%CI, 2.4-2.9). The rural:urban ORs and the 95% CI increased continuously from 2.6, 2.3-3.0 to 2.7, 2.2-3.3, respectively, for 4 consecutive periods during the 22-yr study period. Moreover, the median age of onset among females was higher than that among males (p<0.01). For both sexes and in both areas, the prevalence rates declined and the median age of onset rose for 4 consecutive periods in the 22-yrs time frame (p<0.01). Conculsions: These data reveal the epidemiological profile of ESCC in the area of North China, and suggest that urban areas and rural people account for a growing proportion of the ESCC patients although the prevalence of ESCC significantly declined and the median age-of-onset postponed over the 22-yrs period. Moreover, the prevalence status of ESCC in rural areas also underlines the need for public health initiatives aimed at reducing risk factors of this fatal disease.

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