Comprehensive Analysis of Vascular Endothelial Growth Factor-C Related Factors in Stomach Cancer

  • Liu, Yong-Chao (Department of General Surgery, Huashan Hospital, Fudan University) ;
  • Zhao, Jing (Department of Infectious Diseases, Huashan Hospital, Fudan University) ;
  • Hu, Cheng-En (Department of General Surgery, Huashan Hospital, Fudan University) ;
  • Gan, Jun (Department of General Surgery, Huashan Hospital, Fudan University) ;
  • Zhang, Wen-Hong (Department of Infectious Diseases, Huashan Hospital, Fudan University) ;
  • Huang, Guang-Jian (Department of General Surgery, Huashan Hospital, Fudan University)
  • 발행 : 2014.03.01


Background: Vascular endothelial growth factor-C (VEGF-C), which contributes to lymphatic metastasis (LM) in malignant disease, is one of the most important factors involved in physical and pathological lymphangiogenesis. Some VEGF-C related factors such as sine oculis homeobox homolog (SIX) 1, contactin (CNTN) 1 and dual specificity phosphatase (DUSP) 6 have been extensively studied in malignancies, but their expression levels and associations have still to be elucidated in stomach cancer. Methods: We detected their expression levels in 30 paired stomach cancer tissues using quantitative real-time reverse transcription-PCR (qRT-PCR). The expression and clinical significance of each factor was analyzed using Wilcoxon signed rank sum test. The correlation among all the factors was performed by Spearman rank correlation analysis. Results: The results suggest that VEGF-C and CNTN1 are significantly correlated with tumor size, SIX1 with the age and CNTN1 also with the cTNM stage. There are significant correlations of expression levels among VEGF-C, SIX1, CNTN1 and DUSP6. Conclusions: There exists an important regulatory crosstalk involving SIX1, VEGF-C, CNTN1 and DUSP6 in stomach cancer.


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