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Control of the Motions of Particles in Microfluidic System

미세유동시스템 내에서의 입자의 위치제어 연구

  • Heo, Yun Seok (Department of Biomedical Engineering, Keimyung Univ.)
  • 허윤석 (계명대학교 의과대학 의용공학과)
  • Received : 2014.03.25
  • Accepted : 2014.05.05
  • Published : 2014.06.01

Abstract

Circulating tumor cells (CTCs) in the bloodstream of cancer patients provide an accessible source for detection, characterization, and monitoring of nonhematological cancers. The effectiveness of the CTC-Chip for the isolation of ovarian cancer cells was demonstrated by adapting the herringbone-chip (HB-Chip). The motions of the particles on the HB chip were simulated by a unique combination of buoyant, gravitational forces, and helical flows with a computational modeling. The motions of cells are demonstrated by applying polystylene bead and ovarian cancer cells into the microfabricated HB-Chip. The experimental results from beads and cells are well accordance with the simulated ones, as previously reported by Toner group. Thus, I expect that these modeling and experimental skills will play key roles in the clinical applications on CTC isolation as well as the basic research on characterization of CTCs under flow.

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