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All-trans-retinoic Acid Promotes Iodine Uptake Via Up-regulating the Sodium Iodide Symporter in Medullary Thyroid Cancer Stem Cells

  • Tang, Min (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) ;
  • Hou, Yan-Li (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) ;
  • Kang, Qiang-Qiang (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) ;
  • Chen, Xing-Yue (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) ;
  • Duan, Li-Qun (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) ;
  • Shu, Jin (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) ;
  • Li, Shao-Lin (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) ;
  • Hu, Xiao-Li (Department of Nuclear Medical, The First Affiliated Hospital, Chongqing Medical University) ;
  • Peng, Zhi-Ping (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University)
  • Published : 2014.02.28

Abstract

Recently, the main therapy of medullary thyroid cancer (MTC) is surgical, but by which way there is a poor prognosis with a mean survival of only 5 years. In some cases, some researchers found that it is the medullary thyroid cancer stem cells (MTCSCs) that cause metastasis and recurrence. This study aimed to eradicate MTCSCs through administration of all-trans-retinoic acid (ATRA). Here we demonstrate that MTCSCs possess stemlike properties in serum-free medium. The ABCG2, OCT4 and sodium iodide symporter (NIS) were changed by ATRA. Additionally, we found that ATRA can increase the expression of NIS in vivo. All the data suggested that ATRA could increase the iodine uptake of MTCSCs through NIS.

Keywords

ATRA;medullary thyroid carcinoma stem cells;the capability of radioiodine uptake;$^{131}I$

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