- Volume 15 Issue 4
DOI QR Code
Transrectal Real-time Tissue Elastography - An Effective Way to Distinguish Benign and Malignant Prostate Tumors
- Zhang, Yan (Department of Ultrasound, General Hospital of Chinese PLA) ;
- Tang, Jie (Department of Ultrasound, General Hospital of Chinese PLA) ;
- Liang, Hai-Dong (Information Science and Engineering School, Fudan University) ;
- Lv, Fa-Qin (Department of Ultrasound, General Hospital of Chinese PLA) ;
- Song, Zhi-Gang (Department of Ultrasound, General Hospital of Chinese PLA)
- Published : 2014.02.28
Background: To investigate the relationship between extracellular matrix parameters and texture of prostatic lesions evaluated by transrectal real-time tissue elastography (TRTE). Methods: 120 patients suspicious for prostate cancer underwent TRTE. Targeted biopsies were carried out after 12-core systematic biopsy. Epithelia were stained with hematoxylin-eosin, and Victoria blue and Ponceau S were used to stain elastic-collagen fibers, and picric acid-sirius red for visualization of collagen type I (Col1) and III (Col3). Smooth muscles were visualized by immunohistochemistry. All image analyses were performed in a blind manner using Image Pro Plus 6.0, and the area ratios of epithelium, elastic fibers, collagen fibers and Col1/Col3 were determined. Results: 42 patients with typical elastograms were included in the final data analysis. Significant differences were detected between the benign and malignant groups in the area ratios of epithelium (P = 0.01), smooth muscles and Col1/Col3 (P = 0.04, P = 0.02, respectively). There were no significant differences in the area ratios of epithelium, smooth muscle and elastic fibers between the stiff and soft lesion groups. The area ratio of Col1 was (
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