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In Vitro and in Vivo Antitumor Evaluation of Berbamine for Lung Cancer Treatment

  • Hou, Zhi-Bo (First Department of Respiratory Medicine, Nanjing Chest Hospital & Clinical Center of Nanjing Respiratory Diseases) ;
  • Lu, Kai-Jin (Department of Thoracic Surgery, Jiangsu Taizhou People's Hospital) ;
  • Wu, Xiao-Li (Department of Women Health Care, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University) ;
  • Chen, Cong (Department of Gynecology of Traditional Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine) ;
  • Huang, Xin-En (Department of Chemotherapy, JiangSu Cancer Hospital & Research Institute) ;
  • Yin, Hai-Tao (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University)
  • Published : 2014.02.28

Abstract

Purpose: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers. Methods: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts. Results: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time. Conclusion: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.

Keywords

Berbamine;antitumor;lung cancer;therapy

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