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Whole-liver Radiotherapy Concurrent with Chemotherapy as a Palliative Treatment for Colorectal Patients with Massive and Multiple Liver Metastases: a Retrospective Study

  • Yin, Hang (Department of Radiotherapy, the Cancer Hospital of Harbin Medical University) ;
  • Lu, Kai (The Hospital of Daqing Oilfield) ;
  • Qiao, Wen-Bo (Department of Radiotherapy, the Cancer Hospital of Harbin Medical University) ;
  • Zhang, Hai-Yang (Department of Radiotherapy, the Cancer Hospital of Harbin Medical University) ;
  • Sun, Di (Department of Radiotherapy, the Cancer Hospital of Harbin Medical University) ;
  • You, Qing-Shan (Department of Radiotherapy, the Cancer Hospital of Harbin Medical University)
  • Published : 2014.02.28

Abstract

The purpose of this study was to investigate whether whole-liver radiotherapy plus a tumor-boost dose with concurrent chemotherapy is beneficial for colorectal cancer patients with massive and multiple liver metastases. From January 2007 to December 2012, 19 patients who exhibited massive (with a longest diameter > 5 cm) and invasive liver metastases and multiple metastases were treated with radiotherapy and concurrent chemotherapy. The total radiation dose was 53.4 Gy (range 38.8 Gy-66.3 Gy). All of the patients received a continuous intravenous dose of 5 fluorouracil (5-FU) 225 mg/m2 concurrently with radiation. The median survival time was 19 months. The 1- and 2- year overall survival rates were 78.3% and 14.3%, respectively. Of all of the patients who presented with abdominal pain, 100% experienced a decrease in pain. Decreases in the rates of ascites and jaundice were confirmed by ultrasound and bilirubin levels. No cases of Grade 4 or 5 acute or late toxicity were recorded. There were only two cases of Grade 3 toxicity (elevated bilirubin). These data provide evidence that whole-liver radiotherapy plus a tumor-boost dose with concurrent chemotherapy is beneficial for colorectal cancer patients with massive and multiple liver metastases.

Keywords

Liver metastases;whole-liver irradiation;colorectal cancer;palliative therapy

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