Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population

  • Zhao, Meng-Meng (Department of Epidemiology, School of Public Health, China Medical University) ;
  • Zhang, Yue (Department of Epidemiology, School of Public Health, China Medical University) ;
  • Shen, Li (Department of Epidemiology, School of Public Health, China Medical University) ;
  • Ren, Yang-Wu (Department of Epidemiology, School of Public Health, China Medical University) ;
  • Li, Xue-Lian (Department of Epidemiology, School of Public Health, China Medical University) ;
  • Yin, Zhi-Hua (Department of Epidemiology, School of Public Health, China Medical University) ;
  • Zhou, Bao-Sen (Department of Epidemiology, School of Public Health, China Medical University)
  • Published : 2014.03.30


Background: This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) in telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane1-like (CLPTM1L) and lung cancer risk in a Chinese population. Methods: We performed a hospital-based case-control study, including 980 lung cancer cases and 1000 cancer-free controls matched for age and sex. Each case and control was interviewed to collect information by well-trained interviewers. A total of 5 ml of venous blood was collected for genotype testing of TERT rs2736098 and CLPTM1L rs401681 using TaqMan methodology. Results: The results revealed that the variant homozygote TERT rs2736098TT was associated with an increased risk of lung cancer (OR=2.017, 95%CI=1.518-2.681), especially lung adenocarcinoma (OR=2.117, 95%CI=1.557-3.043) and small cell carcinoma (OR=1.979, 95%CI: 1.174-3.334), compared with the TERT rs2736098CC genotype. Similar results were observed in non-smokers. Conclusion: The TERT rs2736098 polymorphism might affect the susceptibility to lung cancer in Chinese populations. The associations need to be verified in larger and different populations.


Supported by : National Natural Science Foundation of China


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