DOI QR코드

DOI QR Code

Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population

  • Zhao, Meng-Meng ;
  • Zhang, Yue ;
  • Shen, Li ;
  • Ren, Yang-Wu ;
  • Li, Xue-Lian ;
  • Yin, Zhi-Hua ;
  • Zhou, Bao-Sen
  • Published : 2014.03.30

Abstract

Background: This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) in telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane1-like (CLPTM1L) and lung cancer risk in a Chinese population. Methods: We performed a hospital-based case-control study, including 980 lung cancer cases and 1000 cancer-free controls matched for age and sex. Each case and control was interviewed to collect information by well-trained interviewers. A total of 5 ml of venous blood was collected for genotype testing of TERT rs2736098 and CLPTM1L rs401681 using TaqMan methodology. Results: The results revealed that the variant homozygote TERT rs2736098TT was associated with an increased risk of lung cancer (OR=2.017, 95%CI=1.518-2.681), especially lung adenocarcinoma (OR=2.117, 95%CI=1.557-3.043) and small cell carcinoma (OR=1.979, 95%CI: 1.174-3.334), compared with the TERT rs2736098CC genotype. Similar results were observed in non-smokers. Conclusion: The TERT rs2736098 polymorphism might affect the susceptibility to lung cancer in Chinese populations. The associations need to be verified in larger and different populations.

Keywords

Lung cancer;TERT;CLPTM1L;single nucleotide polymorphism;China

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Cited by

  1. Case-Control Study on Impact of the Telomerase Reverse Transcriptase Gene Polymorphism and Additional Single Nucleotide Polymorphism (SNP)- SNP Interaction on Non-Small Cell Lung Cancers Risk in Chinese Han Population vol.30, pp.6, 2016, https://doi.org/10.1002/jcla.21982
  2. ) Gene Variations and Susceptibility of Colorectal Cancer vol.19, pp.12, 2015, https://doi.org/10.1089/gtmb.2015.0150
  3. Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males vol.14, pp.2, 2017, https://doi.org/10.3892/ol.2017.6289
  4. Telomere Maintenance Mechanisms in Cancer vol.9, pp.5, 2018, https://doi.org/10.3390/genes9050241
  5. Association Between TERT rs2736098 Polymorphisms and Cancer Risk-A Meta-Analysis vol.9, pp.1664-042X, 2018, https://doi.org/10.3389/fphys.2018.00377

Acknowledgement

Supported by : National Natural Science Foundation of China