Genetic Polymorphisms of TCF7L2 Lack Influence on Risk of the Polycystic Ovary Syndrome - a Systemic Analysis

  • Lin, Lin (Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University) ;
  • Yang, Jing (Department of Gynecology, Xinjiang People's Hospital of Gynecology) ;
  • Ding, Yan (Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University) ;
  • Wang, Jing (Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University) ;
  • Ting, Liu (Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University)
  • Published : 2014.04.01


Background: The results of previous researches that analyzed the association between genetic polymorphisms of transcription factor-7-like 2 (TCF7L2, rs7903146) and polycystic ovary syndrome (PCOS) were conflicting. Current systematic analysis was conducted to re-explore this association using updated materials. Materials and Methods: The PubMed database was used for data collection and the final search was conducted on January 3, 2014. For TCF7L2 rs7903146, a non-signficiant slight increase in risk of PCOS development was observed under three genetic models (dominant model: OR=1.06, 95%CI: 0.93-1.21, p>0.05; recessive model: OR=1.12, 95%CI: 0.87-1.43, p> 0.05; homozygous model: OR=1.14, 95%CI: 0.87-1.47, p>0.05). In the subgroup analyses in Asian group, allele susceptibility of PCOS was calculated (allele model: OR=1.00, 95%CI: 0.74-1.35, p>0.05; dominant model: OR=0.98, 95%CI: 0.71-1.35, p>0.05; recessive model: OR=1.79, 95%CI: 0.33-9.84, p>0.05; homozygous model: OR=1.78, 95%CI: 0.32-9.80, p>0.05), the differences were again not statistically significant. Conclusions: The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be associated with the susceptibility to PCOS.


Transcription factor-7-like 2;genetic polymorphism;polycystic ovary syndrome


  1. Kim JJ, Choi YM, Cho YM, et al (2012). Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes. Clin Endocrinol, 77, 439-45.
  2. Liu J, Li N, Chang S, et al (2013). Characteristics of 240 Chinese father-child pairs with malignant disease. Asian Pac J Cancer Prev, 14, 6501-5.
  3. Ramos RB, Wiltgen D, Spritzer PM, et al (2013). Polymorphisms of TCF7L2 gene in South Brazilian women with polycystic ovary syndrome: a cross-sectional study. Eur J Endocrinol, 169, 569-76.
  4. Takiar R, Kumar S (2014). Pattern of reproductive cancers in India. Asian Pac J Cancer Prev, 15, 599-603.
  5. Takiar R, Jayant K (2013). A model approach to calculate cancer prevalence from 5 year survival data for selected cancer sites in India. Asian Pac J Cancer Prev, 14, 6899-903.
  6. Xu P, Che YN, Cao YX, et al (2010). Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome. J Assist Reprod Genet 27, 23-8
  7. Azziz R, Carmina E, Dewailly D, et al (2009). The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 96, 456-88.
  8. Barber TM, Bennett AJ, Groves CJ, et al (2007). Disparate genetic influences on polycystic ovary syndrome(PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS. Diabetologia, 50, 2318-22.
  9. Ben-Salem A, Ajina M, Suissi M, et al (2014). Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS). Gene. 533, 554-7.
  10. Bilici A, Inanc M, Ulas A, et al (2013). Clinical and pathologic features of patients with rare ovarian tumors: multi-center review of 167 patients by the anatolian society of medical oncology. Asian Pac J Cancer Prev, 14, 6493-9.
  11. Christopoulos P, Mastorakos G, Gazouli M, et al (2008). Genetic variants in TCF7L2 and KCNJ11 genes in a Greek population with polycystic ovary syndrome. Gynecol Endocrinol, 24, 486-90.
  12. Dunaif A, Finegood DT, (1996). Beta-cell dysfunction independent of obesity and glucoseintolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab, 81, 942-7.
  13. Haroon S, Idrees R, Zia A, et al (2014). Ovarian sex cord stromal tumours in children and young girls-a more than two decade clinicopathological experience in a developing country, pakistan. Asian Pac J Cancer Prev, 15, 1351-5.

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