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Locally Advanced Breast Cancer in Jamaica: Prevalence, Disease Characteristics and Response to Preoperative Therapy

  • Chin, Sheray Nicole (Department of Pathology, University of the West Indies) ;
  • Green, Cheryl May Antoinette (Department of Pathology, University of the West Indies) ;
  • Gordon-Strachan, Georgiana Marie (Faculty of Medical Sciences, University of the West Indies) ;
  • Wharfe, Gilian Helen Frances (Department of Pathology, University of the West Indies)
  • Published : 2014.04.01

Abstract

Breast cancer is the most common cancer in Jamaican women. Locally advanced breast cancer (LABC) is associated with aggressive biology and poor prognosis, and has a predilection for African-American women. In this retrospective review, we assessed the prevalence of LABC as a breast cancer presentation in a population of mainly Afro-centric ethnicity, and determined disease characteristics and response to pre-operative chemotherapy. LABC was prevalent (20%), and had a low pathological response rate to pre-operative chemotherapy, with a high risk of disease recurrence. Increased utilization of breast cancer screening may help detect cancer at less advanced stages, and optimizing pre-operative chemotherapy is recommended to improve response rates and ultimately survival.

Keywords

Breast cancer;locally advanced breast cancer;neoadjuvant chemotherapy;preoperative chemotherapy

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