- Volume 15 Issue 7
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Clinicopathologic Characteristics of Breast Cancer in Jamaica
- Chin, Sheray Nicole (Department of Medicine, Faculty of Medical Sciences, University of the West Indies) ;
- Green, Cheryl (Department of Pathology, Faculty of Medical Sciences, University of the West Indies) ;
- Strachan, Georgiana Gordon (Office of the Dean, Faculty of Medical Sciences, University of the West Indies) ;
- Wharfe, Gilian (Department of Pathology, Faculty of Medical Sciences, University of the West Indies)
- Published : 2014.04.01
Breast cancer is the most common cancer in Jamaican women. This study assessed the clinicopathologic features of cases in a hospital-based specialist clinic in Kingston, Jamaica. A retrospective chart review was performed for the 2-year study period and relevant clinical and surgico-pathologic data were recorded and analyzed. Median age of the 121 breast cancer patients was 52 years (range 22-84, IQR 20) and there was 1 case of male breast cancer. Most patients (65%) were referred from the surgical service after definitive breast cancer surgery, 20% were referred for pre-operative systemic therapy, and 15% had a diagnosis of metastatic disease. The surgico-pathologic group comprised 78 women who were referred for adjuvant therapy. The majority had presented with a palpable breast lump (91%), with median tumour size 3.5cm (range 0.4-13, IQR 4). Most tumours were node positive (56%). Approximately one-third of patients had stage III disease (33%). Most women presented with large palpable tumours and had lymph node involvement confirmed on surgicopathological evaluation, indicative of limited early breast cancer detection. A national screening mammography programme is recommended for detection of earlier lesions. Pre-operative systemic therapy should be considered as an option for eligible patients.
Breast cancer;clinicopathologic characteristics;screening;Jamaica
- Sant M (2001). Differences in stage and therapy for breast cancer across Europe. Int J Cancer, 93, 894-901. https://doi.org/10.1002/ijc.1408
- Sant M, Allemani C, Berrino F, et al (2004). Breast carcinoma survival in Europe and the United States. Cancer, 100, 715-22. https://doi.org/10.1002/cncr.20038
- Seidman H, Gelb SK, Silverberg E, LaVerda N, Lubera JA (1987). Survival experience in the Breast Cancer Detection Demonstration Project. CA Cancer J Clin, 37, 258-90. https://doi.org/10.3322/canjclin.37.5.258
- Shirley SE, Sinclair PE, Stennett MA et al (2010). The Pathology of Breast Cancer in Jamaica: The National Public Health Laboratory study. West Indian Med J, 59, 177-81.
- U.S. Department of Health and Human Services. National Cancer Institute, Surveillance, Epidemiology and End Results Program. SEER cancer statistics review, 1973-1999. [Dataset on CDROM]. Bethesda, MD: U.S. Department of Health and Human Services, 2001.
- Walters JP (1994). Outcome of stage I carcinoma of the breast at the University Hospital of the West Indies (1982-1988). West Indian Med J, 43, 127-9.
- Gibson TN, Blake G, Hanchard B, Waugh N, McNaughton D (2008). Age-specific incidence of cancer in Kingston and St Andrew, Jamaica, 1998-2002. West Indian Med J, 57, 81-9.
- Dent R, Trudeau M, Pritchard KI, et al (2007). Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res, 13, 4429-34. https://doi.org/10.1158/1078-0432.CCR-06-3045
- Edge SB, Compton CC (2010). The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol, 17, 1471-4. https://doi.org/10.1245/s10434-010-0985-4
- Gatta G, Capocaccia R, Coleman MP, et al (2000). Toward a comparison of survival in American and European cancer patients. Cancer, 89, 893-900. https://doi.org/10.1002/1097-0142(20000815)89:4<893::AID-CNCR24>3.0.CO;2-9
- Gibson TN, Hanchard B, Waugh N, McNaughton D (2010). Age-specific incidence of cancer in Kingston and St Andrew, Jamaica, 2003-2007. West Indian Med J, 59, 456-64.
- Jemal A, Clegg LX, Ward E et al (2004). Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer, 101, 3-27. https://doi.org/10.1002/cncr.20288
- Parkin DM, Bray F, Ferlay J, Pisani P (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
- Richardson A, Cox B, Brown T, Smale P (2005). The impact of breast cancer screening on breast cancer registrations in New Zealand. N Z Med J, 118, 1291.
- Salama JK, Heimann R, Lin F, et al (2005). Does the number of lymph nodes examined in patients with lymph node-negative breast carcinoma have prognostic significance? Cancer, 103, 664-71. https://doi.org/10.1002/cncr.20830
- Sant M, Capocaccia R, Verdecchia A, et al (1998). Survival of women with breast cancer in Europe: variation with age, year of diagnosis and country. The EUROCARE Working Group. Int J Cancer, 77, 679-83. https://doi.org/10.1002/(SICI)1097-0215(19980831)77:5<679::AID-IJC3>3.0.CO;2-S
- Alfred R, Chin SN, Williams E, et al (2012). The prevalence and significance of oestrogen receptor (ER) positivity in breast cancer at the University Hospital of the West Indies, Jamaica. West Indian Med J, 61, 795-801.
- Correlation of Tumour Response with Starting Tumour Size and Dose of Tamoxifen in an N-Methyl-N-Nitrosourea (NMU)-Induced Rat Mammary Cancer Model vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6721
- A high frequency of PALB2 mutations in Jamaican patients with breast cancer vol.162, pp.3, 2017, https://doi.org/10.1007/s10549-017-4148-1
- Palliative Care in the Caribbean Through the Lens of Women with Breast Cancer: Challenges and Opportunities vol.10, pp.3, 2018, https://doi.org/10.1007/s12609-018-0280-0