Physical Functions, Health-Related Outcomes, Nutritional Status, and Blood Markers in Community-Dwelling Cancer Survivors Aged 75 Years and Older

  • Ihira, Hikaru (Department of School of Health Sciences, Sapporo Medical University) ;
  • Mizumoto, Atsushi (Department of School of Health Sciences, Sapporo Medical University) ;
  • Makino, Keitarou (Department of School of Health Sciences, Sapporo Medical University) ;
  • Yasuda, Keisuke (Department of Rehabilitation, Obihiro-Kosei General Hospital) ;
  • Miyabe, Yoko (Department of School of Health Sciences, Sapporo Medical University) ;
  • Saitoh, Shigeyuki (Department of School of Health Sciences, Sapporo Medical University) ;
  • Ohnishi, Hirofumi (Department of Public Health, Sapporo Medical University) ;
  • Furuna, Taketo (Department of School of Health Sciences, Sapporo Medical University)
  • Published : 2014.04.01


Background: A cancer survivor is defined as anyone who has been diagnosed with cancer, from the time of diagnosis through the rest of their life. The purpose of this study was to examine whether physical functions, health-related outcomes, nutritional status and blood markers in community-dwelling cancer survivors aged 75 years and older are different from those who do not have cancer Materials and Methods: Two hundred seventy-five participants were asked by physicians, nurses, and physical therapists, questions regarding cancer history in a face-to-face interview. Data were collected for demographic information, physical functions, such as handgrip strength, knee extension power, abdominal muscle strength, static standing balance, walking speed and the timed-up-and-go test, health-related outcomes, nutritional status, and blood markers. The measured parameters of survivor diagnosed with cancer were compared with those without a history of cancer. Results: Thirty-seven older adults were previously diagnosed with cancer. Female cancer survivors had lower knee extension power (p<0.05), abdominal muscle strength (p<0.05), walking speed (p<0.05), timed-up-and-go test score (p<0.05), and time to spend on walking per day (p<0.05) than older women without a history of cancer. In men, none of the measured parameters were significantly different between cancer survivors and older men with no history of cancer. Conclusions: The present study shows that partial physical function of women cancer survivors aged 75 years and older differs from that in women with no history of cancer.


Cancer survivor;health-related quality of life;older women;physical function


  1. Schalk BW, Deeg DJ, Penninx BW, Bouter L, Visser M (2005). Serum albumin and muscle strength: a longitudinal study in older men and women. J Am Geriatr Soc, 53, 1331-8.
  2. Watters JM, Yau JC, O'Rourke K, Tomiak E, Gertler SZ (2003). Functional status is well maintained in older women during adjuvant chemotherapy for breast cancer. Ann Oncol, 14, 1744-50.
  3. Yancik R (2005). Population aging and cancer: a cross-national concern. Cancer J, 11, 437-41.
  4. Prado CM, Lieffers JR, McCargar LJ, et al (2008). Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol, 9, 629-35.
  5. Redfern MS, Jennings JR, Martin C, Furman JM (2001). Attention influences sensory integration for postural control in older adults. Gait Posture, 14, 211-6.
  6. Rock CL, Doyle C, Demark-Wahnefried W, et al (2012). Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin, 62, 243-74.
  7. Shephard RJ, Shek PN (1998). Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med, 26, 293-315.
  8. Shimada H, Kim H, Yoshida H, et al (2010). Factors associated with the timed up and go test score in elderly women. J Phys Ther Sci, 22, 273-8.
  9. Shinkai S, Watanabe S, Kumagai S, et al (2000). Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population. Age Ageing, 29, 441-6.
  10. Sweeney C, Schmitz K, Lazovich D, et al (2006). Functional limitations in elderly female cancer survivors. J Natl Cancer Inst, 98, 521-9.
  11. Takata Y, Ansai T, Yoshihara A, Miyazaki H (2012). Serum albumin (SA) levels and 10-year mortality in a community-dwelling 70-year-old population. Arch Gerontol Geriatr, 54, 39-43.
  12. Valenti M, Porzio G, Aielli F, et al (2008). Physical exercise and quality of life in breast cancer survivors. Int J Med Sci, 15, 24-8.
  13. Maltoni M, Amadori D (2002). Prognosis in advanced cancer. Hematol Oncol Clin North Am, 16, 715-29.
  14. Kurtz M, Kurtz J, Stommel M, GIven C, Given B (1997). Loss of physical functioning among geriatric cancer patients: relationships to cancer site, treatment, and comorbidity and age. Eur J Cancer, 33, 2352-8.
  15. Kwon J, Suzuki T, Kim H, et al (2005). Health status and physical fitness of undernourished community-dwelling elderly people. Jpn J Phys Fitness Sports Med, 54, 99-106.
  16. Lamb SE, Jorstad-Stein EC, Hauer K, Becker C (2005). Development of a common outcome data set for fall injury prevention trials: the prevention of falls network Europe consensus. J Am Geriatr Soc, 53, 1618-22.
  17. Matsuda T, Marugame T, Kamo KI, et al (2012). Cancer incidence and incidence rates in Japan in 2006: based on data from 15 population-based cancer registries in the monitoring of cancer incidence in Japan (MCIJ) project. Jpn J Clin Oncol, 42, 139-47.
  18. McIntosh EN, Laurent LL (1983). Nutritional assessment of the hospitalized patient. Am Fam Physician, 27, 169-75.
  19. Moreland J, Finch E, Stratford P, Balsor B, Gill C (1997). Interrater reliability of six tests of trunk muscle function and endurance. J Orthop Sports Phys Ther, 26, 200-8.
  20. Morley JE, Thomas DR, Wilson MM (2006). Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr, 83, 735-43.
  21. Nordenskiold UM, Grimby G (1993). Grip force in patients with rheumatoid arthritis and fibromyalgia and in healthy subjects. A study with the grippit instrument. Scand J Rheumatol, 22, 14-9.
  22. Podsiadlo D, Richardson S (1991). The timed 'Up & Go': a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc, 39, 142-8.
  23. Given B, Given C, Azzouz F, Stommel M (2001). Physical functioning of elderly cancer patients prior to diagnosis and following initial treatment. Nurs Res, 50, 222-32.
  24. Blair SN, Cheng Y, Holder JS (2001). Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc, 33, 379-99.
  25. Chirikos T, Russell-Jacobs A, Jacobsen P (2002). Functional impairment and the economic consequences of female breast cancer. Women Health, 36, 1-20.
  26. Dobs AS, Boccia RV, Croot CC, et al (2013). Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomized controlled phase 2 trial. Lancet Oncol, 14, 335-45.
  27. Given C, Given B, Azzouz F, Stommel M, Kozachik S (2000). Comparison of changes in physical functioning of elderly patients with new diagnoses of cancer. Med Care, 38, 482-93.
  28. Gotay CC, Muraoka MY (1998). Quality of life in long-term survivors of adult-onset cancers. J Natl Cancer Inst, 90, 656-67.
  29. Inoue M, Yamamoto S, Kurahashi N, et al (2008). Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan. Am J Epidemiol, 168, 391-403.
  30. Keating N, Norredam M, Landrum M, Huskamp H, Meara E (2005). Physical and mental health status of older long-term cancer survivors. J Am Geriatr Soc, 53, 2145-52.
  31. Kimura M, Moriyasu A, Kumagai S, et al (2013). Community-based intervention to improve dietary habits and promote physical activity among older adults: a cluster randomized trial. BMC Geriatr, 23, 13-8.
  32. Koyano W, Shibata H, Nakazato K, Haga H, Suyama Y (1991). Measurement of competence: reliability and validity of the TMIG index of competence. Arch Gerontol Geriatr, 13, 103-16.
  33. Baracos VE, Reiman T, Mourtzakis M, Gioulbasanis I, Antoun S (2010). Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis. Am J Clin Nutr, 91, 1133-7.
  34. Ahern TP, Lash TL, Thwin SS, Silliman RA (2009). Impact of acquired comorbidities on all-cause mortality rates among older breast cancer survivors. Med Care, 47, 73-9.
  35. Baker F, Haffer SC, Denniston M (2003). Health-related quality of life of cancer and noncancer patients in medicare managed care. Cancer, 97, 674-81.
  36. Balducci L, Corcoran MB (2000). Antineoplastic chemotherapy of the older cancer patient. Hematol Oncol Clin North Am, 14, 193-212.
  37. Bech P, Gudex C, Johansen KS (1996). The WHO (Ten) Well-being Index: validation in diabetes. Psychother Psychosom, 65, 183-90.

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