- Volume 15 Issue 7
DOI QR Code
An Updated Meta-analysis Between the Association of XRCC1 Arg399Gln Polymorphism and Hepatocellular Carcinoma Risk
- Zhang, Xiao-Lian (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Lu, Yu (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Yang, Shi (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Peng, Qi-Liu (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Wang, Jian (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Xie, Li (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Deng, Yan (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- He, Yu (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Li, Tai-Jie (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Qin, Xue (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) ;
- Li, Shan (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University)
- Published : 2014.04.01
Background: Various studies have evaluated the relationship between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and hepatocellular carcinoma (HCC) risk, but the conclusions have been inconsistent and underpowered. The purpose of this updated meta-analysis was to examine whether XRCC1 Arg399Gln polymorphism confers susceptibility to HCC. Methods: Eligible studies extracted from PubMed, Embase, Cochrane Library, VIP (chinese) and CNKI (chinese) up to November 2013 were included in the study. Pooled odds ratio (OR) together with their 95% confidence interval (CI) were estimated to evaluate XRCC1 Arg399Gln polymorphism and HCC risk. Results: Finally, 21 studies with 4,170 cases and 5,030 controls were involved in our meta-analysis. The results demonstrated that there was significant association between Arg399Gln polymorphism and HCC risk under two contrast models in overall populations (AG vs GG: OR=1.265, 95%CI=1.036-1.545, p=0.021; AA+AG vs GG: OR=1.240, 95%CI=1.021-1.506, p=0.030). In subgroup analyses, significant association was found in Asians (A vs G: OR=1.175, 95%CI=1.013-1.362, p=0.033; AG vs GG: OR=1.317, 95%CI=1.070-1.622, p=0.009; AA+AG vs GG: OR=1.289, 95%CI=1.055-1.575, p=0.013) and Caucasians (A vs G: OR=0.591, 95%CI=0.361-0.966, p=0.036; AA+AG vs GG: OR=0.468, 95%CI=0.234-0.934, p=0.031). Conclusions: The results suggest that XRCC1 Arg399Gln polymorphism may increase HCC risk especially among Asians. However, XRCC1 Arg399Gln polymorphism might act as a protective role against HCC among Caucasians.
- Yang JL, Han YN, Zheng SG, et al (2004). Influence of human XRCC1-399 single nucleotide polymorphism on primary hepatocytic carcinoma. Tumor, 322-4.
- Yu MW, Yang SY, Pan IJ, et al (2003). Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma. J Natl Cancer Inst, 95, 1485-8. https://doi.org/10.1093/jnci/djg051
- Wu D, Jiang H, Gu Q, et al (2013). Association between XRCC1 Arg399Gln polymorphism and hepatitis virus-related hepatocellular carcinoma risk in Asian population. Tumour Biol, 34, 3265-9. https://doi.org/10.1007/s13277-013-0899-4
- Wu H (2009). Correlation between DNA repair gene XRCC1 single nucleotide polymorphism and susceptibility to hepatocellular carcinoma in Fusui county of Guangxi. Guangxi Medical Unibersity.
- Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
- Su HY (2008). A case-control study on association between genetic polymorphisms of DNA repair and hepatic cell cancer susceptibility. China Medical University.
- Tang YT, Li XP, Liu TQ, et al (2011). Genetic polymorphisms of DNA repair genes in patients with hepatocellular carcinoma. Shandong Med J, 19-20.
- Vidal AE, Boiteux S, Hickson ID, et al (2011). XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions. EMBO J, 20, 6530-9.
- Ren Y, Wang DS, Li Z, et al (2008). Study on the relationship between gene XRCC1 codon 399 single mucleotide polymorphisms and primary hepatic carcinoma in Han nationality. J Clin Hepatol, 361-4.
- Sato K, Mori M (2011). Evolving molecular mechanism-based strategies for control of hepatocellular carcinoma. Curr Med Chem, 18, 4375-88. https://doi.org/10.2174/092986711797200462
- Masson M, Niedergang C, Schreiber V, et al (1998). XRCC1 is specifically associated with poly (ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol, 18, 3563-71. https://doi.org/10.1128/MCB.18.6.3563
- Mei J, Duan HX, Wang LL, et al (2013). XRCC1 polymorphisms and cervical cancer risk: an updated meta-analysis. Tumour Biol, 35, 1221-31.
- Mohana Devi S, Balachandar V, Arun M, et al (2013). Analysis of genetic damage and gene polymorphism in hepatocellular carcinoma (HCC) patients in a South Indian population. Dig Dis Sci, 58, 759-67. https://doi.org/10.1007/s10620-012-2409-8
- Pan HZ, Liang J, Yu Z, et al (2011), Polymorphism of DNA repair gene XRCC1 and hepatocellular carcinoma risk in Chinese population. Asian Pac J Cancer Prev, 12, 2947-50.
- Poehlmann A, Roessner A (2010). Importance of DNA damage checkpoints in the pathogenesis of human cancers. Pathol Res Pract,206, 591-601. https://doi.org/10.1016/j.prp.2010.06.006
- Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
- Long XD, Ma Y, Wei YP, et al (2005). X-ray repair cross-complementing group 1 (xrcc1) arg 399 gln polymorphism and aflatoxin b1 (afb1)-related hepatocellular carcinoma (hcc) in guangxi population. Chinese J Cancer Res, 17-21.
- Long XD, Ma Y, Wei YP, et al (2006). The polymorphisms of GSTM1, GSTT1, HYL1*2, and XRCC1, and aflatoxin B1-related hepatocellular carcinoma in Guangxi population, China. Hepatol Res, 36, 48-55. https://doi.org/10.1016/j.hepres.2006.06.004
- Long XD, Ma Y, Wei YP, et al (2004). Polymorphism of DNA repair gene XRCC1 and risk of hepatocellular carcinoma. J Guangxi Medical University, 313-5.
- Li S, Peng Q, Chen Y, et al (2013). DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk: A meta-analysis. PLoS One, 8, 73448. https://doi.org/10.1371/journal.pone.0073448
- Kirk GD, Turner PC, Gong Y, et al (2005). Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity. Cancer Epidemion Biomarders Prev, 14, 373-9. https://doi.org/10.1158/1055-9965.EPI-04-0161
- Li J, Li Z, Feng L, et al (2013). Polymorpisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis. Tumour Biol, 34, 261-9. https://doi.org/10.1007/s13277-012-0546-5
- Li QW, Lu CR, Ye M, et al (2012). Evaluation of DNA repair gene XRCC1 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Asian Pac J Cancer Prev, 13, 191-4. https://doi.org/10.7314/APJCP.2012.13.1.191
- Jung SW, Park NH, Shin JW, et al (2012). Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: possible implications on survival. J Hepatol, 57, 621-7. https://doi.org/10.1016/j.jhep.2012.04.039
- Kiran M, Saxena R, Chawla YK, et al (2009). Polymorphism of DNA repair gene XRCC1 and hepatitis-related hepatocellular carcinoma risk in Indian population. Mol Cell Biochem, 327, 7-13. https://doi.org/10.1007/s11010-009-0035-3
- Caldwell, Park SH (2009). The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J Gastroenterol, 44, 96-101. https://doi.org/10.1007/s00535-008-2258-6
- Chen CC, Yang SY, Liu CJ, et al (2005). Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma. Int J Epidemiol, 34, 1310-8. https://doi.org/10.1093/ije/dyi191
- Borentain P, Gerolami V, Ananian P, et al (2007). DNA-repair and carcinogen-metabolising enzymes genetic polymorphisms as an independent risk factor for hepatocellular carcinoma in Caucasian liver-transplanted. Eur J Cancer, 43, 2479-86. https://doi.org/10.1016/j.ejca.2007.08.006
- Bose S, Tripathi DM, Sukriti, et al (2013). Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: association with hepatitis B related advanced liver disease and cancer. Gene, 519, 231-7. https://doi.org/10.1016/j.gene.2013.02.025
- Zeng XY, Yu HP, Qiu XQ, et al (2010). A case-control study of polymorphism of XRCC1 gene and the risk of hepatocellular carcinoma. Chinese J Disease Control Prevent, 760-3.
- Zhang H, Wang P, Dai L, et al (2010). Meta-analysis of the relationship between polymorphisms of 399 point of X-ray repair cross complementing gene group 1 and hepatocellular carcinoma. Wei Sheng Yan Jiu, 39, 664-8.
- Jia F, Su H, Li X (2010). Polymorhisms of UGT1A7 and XRCC1 are Associated with an Increased Risk of Hepatocellular Carcinoma in Northeast China. Chinese J Cancer Res, 260-6.
- Hoeijmakers JH (2001). Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-74. https://doi.org/10.1038/35077232
- Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
- Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
- Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
- He GZ, Hung TR, Deng W, et al (2012). Research on Association Between XRCC1 Arg399Gln Polymorphism and Liver Cancer. Journal of Guangxi University Of Chnese Medicine, 1-3.
- Han X, Xing Q, Li Y, et al (2012). Study on the DNA repair gene XRCC1 and XRC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Hepatogastroenterology, 59, 2285-9.
- Han YN, Yang JL, Zheng SG, et al (2004). Study on the association of human XRCC1-399 single nucleotide polymorphism and primary hepatocytic carcinoma. Chinese Hepatology, 235-7.
- Gulnaz A, Sayyed AH, Amin F, et al (2013). Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus. Eur J Gastroenterol Hepatol, 25, 166-79. https://doi.org/10.1097/MEG.0b013e328359a775
- Guo LY, Jin XP, Niu W, et al (2012). Association of XPD and XRCC1 genetic polymorphisms with hepatocellular carcinoma risk. Asian Pac J Cancer Prev, 13, 4423-6. https://doi.org/10.7314/APJCP.2012.13.9.4423
- Hagymasi K, Tulassay Z (2008). [Epidemiology, risk facors and molecular pathogenesis of primary liver cancer]. Orv Hetil, 149, 541-8 (in Hungarian). https://doi.org/10.1556/OH.2008.28313
- Farazi PA, DePinho RA (2006). Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer, 6, 674-87. https://doi.org/10.1038/nrc1934
- Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
- Forner A, Llovet JM, Bruix J (2012). Hepatocellular carcinoma. Lancet, 379, 1245-55. https://doi.org/10.1016/S0140-6736(11)61347-0
- Gomaa AI, Khan SA, Toledano MB, et al (2008). Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol, 14, 4300-8. https://doi.org/10.3748/wjg.14.4300
- Egger M, Davey Smih G, Schneider M, et al (1997). Bias in meta-analysis betected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
- El-Serag HB (2011). Hepatocellular carcinoma. N Engl J Med, 365, 1118-27. https://doi.org/10.1056/NEJMra1001683
- DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
- Ding F, Chen YY, Xie Y, et al (2012). Correlation between XRCC1 genetic Polymorphism Arg399Gln and susceptibility to hepatocellular carcinoma in liver caner family clusters in Fusui county, Guangxi. Chinese J Oncol preve Treat, 33-7.
- Almeida KH, Sobol RW (2007). A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair, 6, 695-711. https://doi.org/10.1016/j.dnarep.2007.01.009
- IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7213
- XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7479
- Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study vol.15, pp.23, 2015, https://doi.org/10.7314/APJCP.2014.15.23.10209
- Polymorphisms in Predicting Prognosis of Hepatocellular Carcinoma in Patients Receiving Transcatheter Arterial Chemoembolization vol.20, pp.4, 2016, https://doi.org/10.1089/gtmb.2015.0267
- Quantitative assessment of the association between XRCC1 Arg399Gln and Arg194Trp polymorphisms and risk of cutaneous melanoma vol.26, pp.3, 2016, https://doi.org/10.1097/CMR.0000000000000246
- The Relationship Between Single-Nucleotide Polymorphisms, the Expression of DNA Damage Response Genes, and Hepatocellular Carcinoma in a Polish Population vol.36, pp.8, 2017, https://doi.org/10.1089/dna.2017.3664
- XRCC1 polymorphism and overall survival in ovarian cancer patients treated with platinum-based chemotherapy vol.97, pp.45, 2018, https://doi.org/10.1097/MD.0000000000012996