Expression of Annexin A3 in Gastric Cancer and its Correlation with Proliferation and Apoptosis

  • Zhai, Jing-Ming (Department of General Surgery, The First Affiliated Hospital Henan University of Science and Technology) ;
  • Sun, Shi-Jun (Department of Pathology, People's Hospital of Zhongshan City) ;
  • Wang, Wei (Department of General Surgery, The First Affiliated Hospital Henan University of Science and Technology) ;
  • Zeng, Chao (Department of Pathology, Guangdong Medical College)
  • Published : 2014.04.01


Annexin A3 has been identified as a novel biomarker in different types of cancers. However, little is known about its clinical significances and and biological roles in gastric cancer. In this study, we assessed annexin A3 expression in 80 patients with gastric cancer and explore its correlation with prognosis Moreover, correlations with Ki-67, Bcl-2 and Bax were also investigated. Expression of annexin A3 was increased in gastric cancer compared with that in normal gastric tissues. Annexin A3 expression was significantly associated with tumor volume and TNM stage (p<0.05). and inversely correlation with prognosis of patients. More interestingly, expression of annexin A3 was positive correlated with Ki-67 and Bcl-2 expression. Our study showed annexin A3 might be a potential prognostic marker for gastric cancer and involved in tumorigenesis by regulating apoptosis and proliferation.


Annexin A3;gastric cancer;apoptosis;proliferation


  1. Zeng C, Ke Z, Song Y, et al (2013). Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance. Exp Mol Pathol, 95, 23-31.
  2. Vogelaar IP, van der Post RS, Bisseling TM, et al (2012). Familial gastric cancer: detection of a hereditary cause helps to understand its etiology. Hered Cancer Clin Pract, 10, 18.
  3. Raynal P, Pollard HB (1994). Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins. Biochim Biophys Acta, 1197, 63-93.
  4. Schostak M, Schwall GP, Poznanovic S, et al (2009). Annexin A3 in urine: a highly specific noninvasive marker for prostate cancer early detection. J Urol, 181, 343-53.
  5. Tan Y, Meng HP, Wu Q, et al (2010). Proteomic study of gallbladder cancer, with special reference on the expression and significance of annexin A3. Chin J Pathol, 39, 382-6.
  6. Wozny W, Schroer K, Schwall GP, et al (2007). Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: cancer association of annexin A3. Proteomics, 7, 313-22.
  7. Wu N, Liu S, Guo C, et al (2013). The role of annexin A3 playing in cancers. Clin Transl Oncol, 15, 106-10.
  8. Xie YQ, Fu D, He ZH, et al (2013). Prognostic value of Annexin A3 in human colorectal cancer and its correlation with hypoxia-inducible factor-$1{\alpha}$. Oncol Lett, 6, 1631-5.
  9. Xie D, Sham JS, Zeng WF, et al (2003). Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. Int J Cancer, 107, 896-902.
  10. Yan X, Yin J, Yao H, et al (2010). Increased expression of annexin A3 is a mechanism of platinum resistance in ovarian cancer. Cancer Res, 70, 1616-24.
  11. Gerke V, Creutz CE, Moss SE (2005). Annexins: linking $Ca^{2+}$ signalling to membrane dynamics. Nature Reviews Molecular Cell Biology, 6, 449-61.
  12. Cao F, Hu YW, Li P, et al (2013). Lymphangiogenic and angiogenic microvessel density in chinese patients with gastric carcinoma: correlation with clinicopathologic parameters and prognosis. Asian Pac J Cancer Prev, 14, 4549-52
  13. Caohuy H, Srivastava M, Pollard HB (1996). Membrane fusion protein synexin (annexin VII) as a $Ca^{2+}$/GTP sensor in exocytotic secretion, Proc Natl Acad Sci USA, 93, 10797-802.
  14. Gerke V, Moss SE (2002). Annexins: from structure to function. Physiological Reviews, 82, 331-71.
  15. Jung EJ, Moon HG, Park ST, et al (2010). Decreased annexin A3 expression correlates with tumor progression in papillary thyroid cancer. Proteomics Clin Appl, 4, 528-37.
  16. Kollermann J, Schlomm T, Bang H, et al (2008). Expression and prognostic relevance of annexin A3 in prostate cancer. Eur Urol, 54, 1314-23.
  17. Li Y, Zhang S, Geng JX, et al (2013). Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C. Asian Pac J Cancer Prev, 14: 4599-602.
  18. Liu YF, Xiao ZQ, Li MX, et al (2009). Quantitative proteome analysis reveals annexin A3 as a novel biomarker in lung adenocarcinoma. J Pathol, 217, 54-64.
  19. Perretti M, Gavins FN (2003). Annexin 1: an endogenous anti-inflamma-tory protein. News Physiol Sci, 18, 60-64.
  20. Bianchi C, Bombelli S, Raimondo F, et al (2010). Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3. Am J Pathol, 176, 1660-70.

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