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Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China

  • Pan, Xiong-Fei (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Wen, Ying (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Loh, Marie (Cancer Science Institute of Singapore, National University of Singapore) ;
  • Wen, Yuan-Yuan (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Yang, Shu-Juan (Department of Child and Adolescent Health, West China School of Public Health, Sichuan University) ;
  • Zhao, Zhi-Mei (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Tian, Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Huang, He (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Lan, Hui (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Chen, Feng (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Soong, Richie (Cancer Science Institute of Singapore, National University of Singapore) ;
  • Yang, Chun-Xia (Department of Epidemiology, West China School of Public Health, Sichuan University)
  • Published : 2014.04.01

Abstract

Background: Gastric carcinogenesis is a complicated process that involves environmental and genetic factors like interleukin-4 (IL-4) and IL-8. Single nucleotide polymorphisms in their genes are associated with changed levels of gene expression. Here, we investigated the association between IL4-590 C>T and IL8-251T>A and gastric cancer (GC) risk in Sichuan of Southwestern China. Materials and Methods: We surveyed the research subjects using a self-designed questionnaire with questions on demographic factors and putative risk factors. Approximately 2-5ml of whole blood was collected after field survey to analyze IL4-590 C>T and IL8-251T>A genotypes using MALDI-TOF MS. Results: Our study recruited 308 pairs of GC patients and controls, including 224 (72.7%) men and 84 (27.3%) women in each group. There were 99 cardia and 176 noncardia GC patients in the case group. The case and control groups had an average age of $57.7{\pm}10.6$ ($mean{\pm}SD$) and $57.6{\pm}11.1$ years. GC patients reported a significantly greater proportion of family history of cancer (29.9% vs 10.7%, p<0.01) and drinking (54.6% vs 43.2%, p<0.01) than did controls. Variant genotypes of IL-4-590 C>T and IL-8-251 T>A were not associated with overall GC risk (adjusted OR, 0.89; 95%CI, 0.61-1.28 for CT or CC vs TT; adjusted OR, 1.14; 95%CI, 0.86-1.79 for TA or AA vs TT). Stratification analysis of two SNPs for risk by subsites only found that variant IL-8-251 TA or AA genotype was associated with increased noncardia GC risk (adjusted OR, 2.58; 95%CI, 1.19-5.57). We did not observe interactions between the IL-8-251 T>A genotype and smoking (adjusted OR, 0.38; 95%CI, 0.08-1.79) or drinking (adjusted OR, 0.36; 95%CI, 0.08-1.65) for risk of noncardia GC. Conclusions: Our data indicate no association between the two SNPs of IL-4-590 and IL-8-251 with overall GC risk, while the IL-8-251 TA or AA genotype conferred risk of cardia GC. Our findings contribute to the evidence body for risk of SNPs associated with the development of gastric cancer in this region.

Keywords

Gastric cancer;interleukin-4 gene;interleukin-8 gene;polymorphism;risk;case-control study

References

  1. Garcia-Gonzalez MA, Lanas A, Quintero E, et al (2007). Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: A nationwide multicenter study in Spain. Am J Gastroenterol, 102, 1878-92. https://doi.org/10.1111/j.1572-0241.2007.01423.x
  2. Ferlay J, Shin HR, Bray F, et al (2010). GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet], Lyon, France: International Agency for Research on Cancer; 2010.
  3. Fox JG, Wang TC (2007). Inflammation, atrophy, and gastric cancer. J Clin Invest, 117, 60-9. https://doi.org/10.1172/JCI30111
  4. Gao LB, Pan XM, Jia J, et al (2010). IL-8 -251A/T polymorphism is associated with decreased cancer risk among population-based studies: evidence from a meta-analysis. Eur J Cancer, 46, 1333-43. https://doi.org/10.1016/j.ejca.2010.03.011
  5. Gianfagna F, De Feo E, Van Duijn CM, et al (2008). A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk. Curr Genomics, 9, 361-74. https://doi.org/10.2174/138920208785699544
  6. Gonzalez CA, Agudo A (2012). Carcinogenesis, prevention and early detection of gastric cancer: where we are and where we should go. Int J Cancer, 130, 745-53. https://doi.org/10.1002/ijc.26430
  7. Gonzalez CA, Sala N, Capella G (2002). Genetic susceptibility and gastric cancer risk. Int J Cancer, 100, 249-60. https://doi.org/10.1002/ijc.10466
  8. He YT, Hou J, Chen ZF, et al (2008). Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China. Eur J Cancer Prev, 17, 71-6. https://doi.org/10.1097/CEJ.0b013e3282b6fd97
  9. Health CMO (2011). China Health Statistics Yearbook - 2010, Beijing:Peking Union Medical College Press, 2010.
  10. Heidl G, Langhans P, Krieg V, et al (1993). Comparative studies of cardia carcinoma and infracardial gastric carcinoma. J Cancer Res Clin Oncol, 120, 91-4. https://doi.org/10.1007/BF01200730
  11. Ando T, Ishikawa T, Kato H, et al (2009). Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection. Int J Cancer, 125, 2595-602. https://doi.org/10.1002/ijc.24666
  12. Bertuccio P, Chatenoud L, Levi F, et al (2009). Recent patterns in gastric cancer: a global overview. Int J Cancer, 125, 666-73. https://doi.org/10.1002/ijc.24290
  13. Blaser MJ (1999). Hypothesis: the changing relationships of Helicobacter pylori and humans: implications for health and disease. J Infect Dis, 179, 1523-30. https://doi.org/10.1086/314785
  14. Brenner H, Arndt V, Stegmaier C, et al (2004). Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer? Am J Epidemiol, 159, 252-8. https://doi.org/10.1093/aje/kwh039
  15. Brown LM, Devesa SS (2002). Epidemiologic trends in esophageal and gastric cancer in the United States. Surg Oncol Clin N Am, 11, 235-56.
  16. Camargo MC, Mera R, Correa P, et al (2006). Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 15, 1674-87. https://doi.org/10.1158/1055-9965.EPI-06-0189
  17. Canedo P, Castanheira-Vale AJ, Lunet N, et al (2008). The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population. Eur J Cancer Prev, 17, 28-32. https://doi.org/10.1097/CEJ.0b013e32809b4d0f
  18. Crew KD, Neugut AI (2006). Epidemiology of gastric cancer. World J Gastroenterol, 12, 354-62. https://doi.org/10.3748/wjg.v12.i3.354
  19. Crusius JBA, Canzian F, Capella G, et al (2008). Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Ann Oncol, 19, 1894-902. https://doi.org/10.1093/annonc/mdn400
  20. Zeng ZR, Zhou SZ, Liao SY, et al (2005). Correlation of polymorphism of interleukin 8 gene-251 locus and gastric cancer in high and low prevalence regions in China (Chinese). J Sun Yat-sen Univ (Med Sci), 537-40.
  21. Zhang J, Xie D, Zhou H, et al (2013). The -590C/T polymorphism in the IL-4 gene and the risk of cancer: a meta-analysis. Tumour Biol, 34, 2261-8. https://doi.org/10.1007/s13277-013-0767-2
  22. Zhang L, Du C, Guo X, et al (2010). Interleukin-8-251A/T polymorphism and Helicobacter pylori infection influence risk for the development of gastric cardiac adenocarcinoma in a high-incidence area of China. Mol Biol Rep, 37, 3983-9. https://doi.org/10.1007/s11033-010-0057-7
  23. Wen YY, Pan XF, Loh M, et al (2012). ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pac J Cancer Prev, 13, 2139-44. https://doi.org/10.7314/APJCP.2012.13.5.2139
  24. Thun MJ, Delancey JO, Center MM, et al (2010). The global burden of cancer: priorities for prevention. Carcinogenesis, 31, 100-10. https://doi.org/10.1093/carcin/bgp263
  25. Wang J, Pan HF, Hu YT, et al (2010). Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis. Dig Dis Sci, 55, 1818-23. https://doi.org/10.1007/s10620-009-0978-y
  26. Wang N, Zhou R, Wang C, et al (2012). -251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case-control studies. Mol Biol Rep, 39, 2831-41. https://doi.org/10.1007/s11033-011-1042-5
  27. Wu MS, Wu CY, Chen CJ, et al (2003). Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. Int J Cancer, 104, 617-23. https://doi.org/10.1002/ijc.10987
  28. Xue H, Liu J, Lin B, et al (2012). A meta-analysis of interleukin-8-251 promoter polymorphism associated with gastric cancer risk. Plos One, 7, 28083. https://doi.org/10.1371/journal.pone.0028083
  29. Ye BD, Kim SG, Park JH, et al (2009). The interleukin-8-251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pylori-infected Koreans. J Clin Gastroenterol, 43, 233-9. https://doi.org/10.1097/MCG.0b013e3181646701
  30. Yuzhalin A (2011). The role of interleukin DNA polymorphisms in gastric cancer. Hum Immunol, 72, 1128-36. https://doi.org/10.1016/j.humimm.2011.08.003
  31. Pan XF, Yang SJ, Loh M, et al (2013). Interleukin-10 gene promoter polymorphisms and risk of gastric cancer in a Chinese population: single nucleotide and haplotype analyses. Asian Pac J Cancer Prev, 14, 2577-82. https://doi.org/10.7314/APJCP.2013.14.4.2577
  32. Macarthur M, Hold GL, El-Omar EM (2004). Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy. Am J Physiol Gastrointest Liver Physiol, 286, 515-20. https://doi.org/10.1152/ajpgi.00475.2003
  33. Mccoll KE, El-Omar E, Gillen D (2000). Helicobacter pylori gastritis and gastric physiology. Gastroenterol Clin North Am, 29, 687-703. https://doi.org/10.1016/S0889-8553(05)70138-2
  34. Pan XF, Xie Y, Loh M, et al (2012). Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study. Asian Pac J Cancer Prev, 13, 5637-42. https://doi.org/10.7314/APJCP.2012.13.11.5637
  35. Persson C, Canedo P, Machado JC, et al (2011). Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses. Am J Epidemiol, 173, 259-70. https://doi.org/10.1093/aje/kwq370
  36. Rosenwasser LJ, Klemm DJ, Dresback JK, et al (1995). Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy, 25, 74-8. https://doi.org/10.1111/j.1365-2222.1995.tb00428.x
  37. Schneider BG, Camargo MC, Ryckman KK, et al (2008). Cytokine polymorphisms and gastric cancer risk: an evolving view. Cancer Biol Ther, 7, 157-62. https://doi.org/10.4161/cbt.7.2.5270
  38. Shen LY (2011). China Statisticl yearbook, Beijing: China Statistics Press, 2008.
  39. Sugimoto M, Yamaoka Y, Furuta T (2010). Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer. World J Gastroenterol, 16, 1188-200. https://doi.org/10.3748/wjg.v16.i10.1188
  40. Taguchi A, Ohmiya N, Shirai K, et al (2005). Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. Cancer Epidemiol Biomarkers Prev, 14, 2487-93. https://doi.org/10.1158/1055-9965.EPI-05-0326
  41. Lee WP, Tai DI, Lan KH, et al (2005). The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population. Clin Cancer Res, 11, 6431-41. https://doi.org/10.1158/1078-0432.CCR-05-0942
  42. Kitadai Y, Takahashi Y, Haruma K, et al (1999). Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice. Br J Cancer, 81, 647-53. https://doi.org/10.1038/sj.bjc.6690742
  43. Lagergren J, Bergstrom R, Lindgren A, Nyren O (1999). Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med, 340, 825-31. https://doi.org/10.1056/NEJM199903183401101
  44. Lai KC, Chen WC, Jeng LB, et al (2005). Association of genetic polymorphisms of MK, IL-4, p16, p21, p53 genes and human gastric cancer in Taiwan. Eur J Surg Oncol, 31, 1135-40. https://doi.org/10.1016/j.ejso.2005.07.005
  45. Lin XH (2008). Correlation of interleukin 4-590 and intron 3 polymorphisms to genetic susceptibility to gastric cardiac carcinoma and noncardiac gastric carcinoma (Chinese).
  46. Liu C, Russell RM (2008). Nutrition and gastric cancer risk: an update. Nutr Rev, 66, 237-49. https://doi.org/10.1111/j.1753-4887.2008.00029.x
  47. Liu L, Zhuang W, Wang C, et al (2010). Interleukin-8 -251 A/T gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiological studies. Cytokine, 50, 328-34. https://doi.org/10.1016/j.cyto.2010.03.008
  48. Loh M, Koh KX, Yeo BH, et al (2009). Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race. Eur J Cancer, 45, 2562-8. https://doi.org/10.1016/j.ejca.2009.03.017
  49. Lu W, Pan K, Zhang L, et al (2005). Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population. Carcinogenesis, 26, 631-6. https://doi.org/10.1093/carcin/bgh349
  50. Kamangar F, Abnet CC, Hutchinson AA, et al (2006). Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control, 17, 117-25. https://doi.org/10.1007/s10552-005-0439-7
  51. Heidl G, Langhans P, Mellin W, et al (1993). Adenocarcinomas of esophagus and cardia in comparison with gastric carcinoma. J Cancer Res Clin Oncol, 120, 95-9. https://doi.org/10.1007/BF01200731
  52. Hull J, Thomson A, Kwiatkowski D (2000). Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax, 55, 1023-7. https://doi.org/10.1136/thorax.55.12.1023
  53. Ju D, Sun D, Xiu L, et al (2012). Interleukin-8 is associated with adhesion, migration and invasion in human gastric cancer SCG-7901 cells. Med Oncol, 29, 91-9. https://doi.org/10.1007/s12032-010-9780-0
  54. Justenhoven C, Hamann U, Pesch B, et al (2004). ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a German population. Cancer Epidem Biomar, 13, 2059-64.
  55. Kamangar F, Dawsey SM, Blaser MJ, et al (2006). Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity. J Natl Cancer Inst, 98, 1445-52. https://doi.org/10.1093/jnci/djj393
  56. Kamangar F, Dores GM, Anderson WF (2006). Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 24, 2137-50. https://doi.org/10.1200/JCO.2005.05.2308
  57. Kang JM, Kim N, Lee DH, et al (2009). The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. J Clin Gastroenterol, 43, 420-8. https://doi.org/10.1097/MCG.0b013e318178d1d3
  58. Kato I, Canzian F, Franceschi S, et al (2006). Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela. Cancer Causes Control, 17, 1183-91. https://doi.org/10.1007/s10552-006-0060-4

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