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Positive Effects of Oral β-Glucan on Mucositis and Leukopenia in Colorectal Cancer Patients Receiving Adjuvant FOLFOX-4 Combination Chemotherapy

  • Karaca, Halit (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Bozkurt, Oktay (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Ozaslan, Ersin (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Baldane, Suleyman (Department of Internal Medicine, Erciyes University Medical Faculty) ;
  • Berk, Veli (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Inanc, Mevlude (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Duran, Ayse Ocak (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Dikilitas, Mustafa (Department of Medical Oncology, Acibadem Hospital) ;
  • Er, Ozlem (Department of Medical Oncology, Acibadem Hospital) ;
  • Ozkan, Metin (Department of Medical Oncology, Erciyes University Medical Faculty)
  • 발행 : 2014.04.30

초록

The present study aimed to determine the effect of oral ${\beta}$-glucan on mucositis and leukopenia in 62 consecutive patients with colorectal cancer treated with an adjuvant FOLFOX-4 regimen. The patients were retrospectively evaluated in 2 groups: one group received ${\beta}$-glucan and the other did not (control group). Leucocytes, neutrophils, and platelets were evaluated before and 1 week after chemotherapy and oral mucositis and diarrhea were noted. Leucocyte and neutrophil counts after chemotherapy in the ${\beta}$-glucan group were $7,300/mm^3$ and $3,800/mm^3$, respectively, and the reductions, as compared to baseline, were not significant (p=0.673 and 0.784). The median platelet count was $264,000/mm^3$ after chemotherapy in the ${\beta}$-glucan group and the reduction, as compared to baseline, was borderline significant (p=0.048). In the control group, reduction in leucocyte, neutrophil, and platelet counts was statistically significant. Oral mucositis and diarrhea were less common in the ${\beta}$-glucan group. We conclude that ${\beta}$-glucan can be used to reduce the adverse effects of chemotherapy.

참고문헌

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피인용 문헌

  1. Effect of Beta Glucan on White Blood Cell Counts and Serum Levels of IL-4 and IL-12 in Women with Breast Cancer Undergoing Chemotherapy: A Randomized Double-Blind Placebo-Controlled Clinical Trial vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5733
  2. Risk Factors for Chemotherapy-Induced Leukopenia in Patients with Lung Cancer vol.07, pp.03, 2016, https://doi.org/10.4236/ijcm.2016.73023
  3. Consumption of β-glucans to spice up T cell treatment of tumors: a review vol.18, pp.10, 2018, https://doi.org/10.1080/14712598.2018.1523392
  4. Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis pp.1552-695X, 2018, https://doi.org/10.1177/1534735418794885