DOI QR코드

DOI QR Code

Induced Abortion and Breast Cancer: Results from a Population-Based Case Control Study in China

  • Wu, Jun-Qing (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health) ;
  • Li, Yu-Yan (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health) ;
  • Ren, Jing-Chao (College of Medical in Xinxiang) ;
  • Zhao, Rui (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health) ;
  • Zhou, Ying (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health) ;
  • Gao, Er-Sheng (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health)
  • Published : 2014.04.30

Abstract

Aim: To determine whether induced abortion (IA) increases breast cancer (BC) risk. Materials and Methods: A population-based case-control study was performed from Dec, 2000 to November, 2004 in Shanghai, China, where IA could be verified through the family planning network and client medical records. Structured questionnaires were completed by 1,517 cases with primary invasive epithelial breast cancer and 1,573 controls frequency-matched to cases for age group. The information was supplemented and verified by the family planning records. Statistical analysis was conducted with SAS 9.0. Results: After adjusting for potential confounders, induced abortions were not found to be associated with breast cancer with OR=0.94 (95%CI= 0.79-1.11). Compared to parous women without induced abortion, parous women with 3 or more times induced abortion (OR=0.66, 95%CI=0.46 to 0.95) and women with 3 or more times induced abortion after the first live birth (OR=0.66, 95%CI =0.45 to 0.97) showed a lower risk of breast cancer, after adjustment for age, level of education, annual income per capita, age at menarche, menopause, parity times, spontaneous abortion, age at first live birth, breast-feeding, oral contraceptives, hormones drug, breast disease, BMI, drinking alcohol, drinking tea, taking vitamin/calcium tablet, physical activity, vocation, history of breast cancer, eating the bean. Conclusions: The results suggest that a history of induced abortions may not increase the risk of breast cancer.

References

  1. Ozmen V, Ozcinar B, Karanlik H, et al (2009). Breast cancer risk factors in Turkish women-a University Hospital based nested case control study. World J Surg Oncol, 7, 37. https://doi.org/10.1186/1477-7819-7-37
  2. Michels KB, Hsieh CC, Trichopoulos D, et al (1995). Abortion and breast cancer risk in seven countries. Cancer Causes Control, 6, 75-82. https://doi.org/10.1007/BF00051683
  3. Ministry of Public Health of the People's Republic of China (2010). China Statistical Yearbook. Publishing House of China Statistics, Beijing, 207.
  4. Naieni KH, Ardalan A, Mahmoodi M, et al (2007). Risk factors of breast cancer in north of Iran: a case-control in Mazandaran Province. Asian Pac J Cancer Prev, 8, 395-8.
  5. Russo J, Russo IH (1987). Biological and molecular bases of mammary carcinogenesis. Lab Invest, 57, 112-37.
  6. Russo IH, Koszalka M, Russo J (1991). Comparative study of the influence of pregnancy and hormonal treatment on mammary carcinogenesis. Br J Cancer, 64, 481-4. https://doi.org/10.1038/bjc.1991.335
  7. Sanderson M, Shu XO, Jin F, et al (2001). Abortion history and breast cancer risk: results from the Shanghai Breast Cancer Study. Int J Cancer, 92, 899-905. https://doi.org/10.1002/ijc.1263
  8. Thorp JM, Hartmann KE, Shadigian E (2003). Long-term physical and psychological health consequences of induced abortion: review of the evidence. Obstet Gynecol Surv, 58, 67-7. https://doi.org/10.1097/00006254-200301000-00023
  9. Toleutay U, Reznik V, Kalmatayeva Z, et al (2013). Risk factors of breast cancer in Kyzylorda oblast of Kazakhstan: a casecontrol study. Asian Pac J Cancer Prev, 14, 5961-4. https://doi.org/10.7314/APJCP.2013.14.10.5961
  10. Ye Z, Gao DL, Qin Q, et al (2002). Breast cancer in relation to induced abortions in a cohort of Chinese women. Br J Cancer, 87, 977-81. https://doi.org/10.1038/sj.bjc.6600603
  11. Yan Zhou, Jingrong Xiao, Huijuan Jiang (2010). Incidence trend of female breast cancer in Fuzhou city, 1991-2005. Chin J Nat Med, 12, 183-5.
  12. Lindefors-Harris BM, Edklund G, Meirik O, et al (1989). Risk of cancer of the breast after legal abortion during first trimester: a Swedish register study. BMJ, 299, 1430-2. https://doi.org/10.1136/bmj.299.6713.1430
  13. Hulka BS, Moorman PG (2001). Breast cancer: hormones and other risk factors. Maturitas, 38, 103-16. https://doi.org/10.1016/S0378-5122(00)00196-1
  14. Henderson KD, Sullivan-Halley J, Reynolds P, et al (2008). Incomplete pregnancy is not associated with breast cancer risk: the California Teachers Study. Contraception, 77, 391-6. https://doi.org/10.1016/j.contraception.2008.02.004
  15. Hadjisavvas A, Loizidou MA, Middleton N, et al (2010). An investigation of breast cancer risk factors in Cyprus: a case control study. BMC Cancer, 10, 447. https://doi.org/10.1186/1471-2407-10-447
  16. Mahue-Giangreco M, Ursin G, Sullivan-Halley J, et al (2003). Induced abortion, miscarriage, and breast cancer risk of young women. Cancer Epidemiol Biomarkers Prev, 12, 209-14.
  17. Michels KB, Xue F, Colditz GA, et al (2007). Induced and spontaneous abortion and incidence of breast cancer among young women: a prospective cohort study. Arch Intern Med, 167, 814-20. https://doi.org/10.1001/archinte.167.8.814
  18. Ma H, Henderson KD, Sullivan-Halley J, et al (2010). Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort. Breast Cancer Res, 12, 35.
  19. Jemal A, Center MM, Desantis C, et al (2010). Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev, 19, 1893-907. https://doi.org/10.1158/1055-9965.EPI-10-0437
  20. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  21. Jiang AR, Gao CM, Ding JH, et al (2012). Abortions and breast cancer risk in premenopausal and postmenopausal women in Jiangsu Province in China. Asian Pac J Cancer Prev, 13, 33-5. https://doi.org/10.7314/APJCP.2012.13.1.033
  22. Coleman PK, Rue VM, Coyle CT (2009). Induced abortion and intimate relationship quality in the Chicago Health and Social Life Survey. Public Health, 4, 331-8.
  23. Costarelli V, Yiannakouris N (2010). Breast cancer risk in women: the protective role of pregnancy. Nurs Stand, 24, 35-40.
  24. Daling JR, Brinton LA, Voigt LF, et al (1996). Risk of breast cancer among white women following induced abortion. Am J Epidemiol, 144, 373-80. https://doi.org/10.1093/oxfordjournals.aje.a008938
  25. Dandan He, Chunfang Wang, Lili Cao, et al (2010). Epidemic trend of female breast cancer incidence in Minhang district, Shanghai. China Cancer, 19, 108-10.
  26. Erlandsson G, Montgomery SM, Cnattingius S, et al (2003). Abortions and breast cancer: record-based case-control study. Int J Cancer, 103, 676-9. https://doi.org/10.1002/ijc.10877
  27. Friedman E, Kotsopoulos J, Lubinski, J, et al (2006). Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers. Breast Cancer Res, 8, R15. https://doi.org/10.1186/bcr1387
  28. Yanhua C, Greater A, You J, et al (2012). Reproductive variables and risk of breast malignant and benign tumours in Yunnan province, China. Asian Pac J Cancer Prev, 13, 2179-84. https://doi.org/10.7314/APJCP.2012.13.5.2179

Cited by

  1. Short-Hairpin RNA-Mediated MTA2 Silencing Inhibits Human Breast Cancer Cell Line MDA-MB231 Proliferation and Metastasis vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5577
  2. Induced abortion and breast cancer vol.97, pp.3, 2018, https://doi.org/10.1097/MD.0000000000009613
  3. Induced Abortion, Birth Control Methods, and Breast Cancer Risk: A Case-Control Study in China pp.1349-9092, 2018, https://doi.org/10.2188/jea.JE20170318