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Inferring Single Nucleotide Polymorphisms in MicroRNA Binding Sites of Lung Cancer-related Inflammatory Genes

  • He, Fei (Department of Epidemiology, School of Public Health, Fujian Medical University) ;
  • Zheng, Ling-Ling (Department of Prevention and Health Care, FuJian Medical University Uion Hospital) ;
  • Luo, Wen-Ting (Department of Chronic and Endemic Disease Control, Xiamen Center for Disease Control and Prevention) ;
  • Yang, Rong (Department of Medical Record Management, FuJian Medical University Uion Hospital) ;
  • Xu, Xiao-Qin (School Office, School of Nursing, Fujian Medical University) ;
  • Cai, Lin (Department of Epidemiology, School of Public Health, Fujian Medical University)
  • Published : 2014.04.30

Abstract

Single nucleotide polymorphisms located at microRNA (miRNA)-binding sites are likely to affect the expression of miRNA targets and may contribute to the susceptibility of humans to common diseases. Here 335 candidate lung cancer-related inflammatory genes were selected according to the existing literature and database. We identified putative miRNA-binding sites of 149 genes by specialised algorithms and screened SNPs in the 3'UTRs of these genes. By calculating binding free energy, we sorted 269 SNPs on the basis of the possibility of prediction. The proposed approach could help to easy the identification of functionally relevant SNPs and minimize the workflow and the costs.

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