DOI QR코드

DOI QR Code

The Promise of Dried Fruits in Cancer Chemoprevention

  • 발행 : 2014.04.30

초록

Chemoprevention is an attempt to use nontoxic natural and synthetic substances or their mixtures to intervene the relatively early stages of carcinogenesis, before invasive characteristics are manifested. The consumption of fruits is well known to reduce the risk of human cancers. Although most fruits are available only on a seasonal basis, recent advances in food processing technologies have made it possible to extend the shelf life of fruits and fruit-products. Fruits can be preserved by applying different drying processes to reduce the moisture content. Different varieties of dried fruits are now sold in supermarkets, thereby making them readily accessible to consumers. Since oxidative stress and chronic inflammation play important roles in cancer development, dried fruits with antioxidative and anti-inflammatory properties hold promise for cancer chemoprevention. The antioxidant, anti-inflammatory and chemopreventive activities of dried fruits are largely attributed to their polyphenols and vitamins. Dried fruits contain adequate amounts of bioactive principles, such as anthocyanins, acetogenins, catechins, coumarins, phenolic acids, terpenes, xanthones, and others. Since numerous health beneficial phytochemicals in fruits are conserved even after processing, regular intake of dried fruits can help prevent cancer. This review addresses the chemopreventive potential of representative dried fruits and their active constituents.

과제정보

연구 과제 주관 기관 : Keimyung University

참고문헌

  1. Adams LS, Kanaya N, Phung S, Liu Z, Chen S (2011). Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J Nutr, 141, 1805-12. https://doi.org/10.3945/jn.111.140178
  2. Adams LS, Phung S, Yee N, et al (2010). Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70, 3594-605. https://doi.org/10.1158/0008-5472.CAN-09-3565
  3. Adhami VM, Siddiqui IA, Syed DN, Lall RK, Mukhtar H (2012). Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model. Carcinogenesis, 33, 644-51. https://doi.org/10.1093/carcin/bgr308
  4. Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H (2005). Anthocyanin-and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int J Cancer, 113, 423-33. https://doi.org/10.1002/ijc.20587
  5. Aiyer HS, Srinivasan C, Gupta RC (2008). Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats. Nutr Cancer, 60, 227-34. https://doi.org/10.1080/01635580701624712
  6. Alias LM, Manoharan S, Vellaichamy L, Balakrishnan S, Ramachandran CR (2009). Protective effect of ferulic acid on 7,12-dimethylbenz[a]anthracene-induced skin carcinogenesis in Swiss albino mice. Exp Toxicol Pathol, 61, 205-14. https://doi.org/10.1016/j.etp.2008.09.001
  7. Balakrishnan S, Menon VP, Manoharan S (2008). Ferulic acid inhibits 7, 12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. J Med Food, 11, 693-700. https://doi.org/10.1089/jmf.2007.0103
  8. Banerjee N, Kim H, Talcott S, Mertens-Talcott S (2013). Pomegranate polyphenolics suppressed azoxymethaneinduced colorectal aberrant crypt foci and inflammation:possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR. Carcinogenesis, 34, 2814-22. https://doi.org/10.1093/carcin/bgt295
  9. Baskaran N, Manoharan S, Balakrishnan S, Pugalendhi P (2010). Chemopreventive potential of ferulic acid in 7, 12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats. Eur J Pharmacol, 637, 22-9. https://doi.org/10.1016/j.ejphar.2010.03.054
  10. Berardini N, Knodler M, Schieber A, Carle R (2005a). Utilization of mango peels as a source of pectin and polyphenolics. Innov Food Sci Emerg, 6, 442-52. https://doi.org/10.1016/j.ifset.2005.06.004
  11. Berardini N, Schieber A, Klaiber I, et al (2005b). 7-0-Methylcyanidin 3-0-beta-D-galactopyranoside, a novel anthocyanin from mango (Mangifera indica L. cv. 'Tommy Atkins') peels. Z Naturforsch B, 60, 801-04.
  12. Bhattacharyya SS, Paul S, Dutta S, Boujedaini N, Khuda-Bukhsh AR (2010). Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz[a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. Zhong Xi Yi Jie He Xue Bao, 8, 645-54. https://doi.org/10.3736/jcim20100708
  13. Bishayee A, Mbimba T, Thoppil RJ, et al (2011). Anthocyaninrich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats. J Nutr Biochem, 22, 1035-46. https://doi.org/10.1016/j.jnutbio.2010.09.001
  14. Casto BC, Knobloch TJ, Galioto RL, et al (2013). Chemoprevention of oral cancer by lyophilized strawberries. Anticancer Res, 33, 4757-66.
  15. Chen JP, Tai CY, Chen BH (2004). Improved liquid chromatographic method for determination of carotenoids in Taiwanese mango (Mangifera indica L.). Journal of Chromatography A, 1054, 261-8. https://doi.org/10.1016/j.chroma.2004.08.100
  16. Chung YC, Lin CC, Chou CC, Hsu CP (2010). The effect of Longan seed polyphenols on colorectal carcinoma cells. Eur J Clin Invest, 40, 713-21. https://doi.org/10.1111/j.1365-2362.2010.02322.x
  17. Cooke D, Schwarz M, Boocock D, et al (2006). Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels. Int J Cancer, 119, 2213-20. https://doi.org/10.1002/ijc.22090
  18. Dennert G, Zwahlen M, Brinkman M, et al (2011). Selenium for preventing cancer. Cochrane Db Syst Rev, 11, 1-131.
  19. Ding H, Chin YW, Kinghorn AD, D’Ambrosio SM (2007). Chemopreventive characteristics of avocado fruit. Semin Cancer Biol, 17, 386-94. https://doi.org/10.1016/j.semcancer.2007.04.003
  20. Donovan JL, Meyer AS, Waterhouse AL (1998). Phenolic composition and antioxidant activity of prunes and prune juice (Prunus domestica). J Agr Food Chem, 46, 1247-52. https://doi.org/10.1021/jf970831x
  21. Duncan FJ, Martin JR, Wulff BC, et al (2009). Topical Treatment with black raspberry extract reduces cutaneous UVBinduced carcinogenesis and inflammation. Cancer Prev Res, 2, 665-72. https://doi.org/10.1158/1940-6207.CAPR-08-0193
  22. Enomoto S, Yanaoka K, Utsunomiya H, et al (2010). Inhibitory effects of Japanese apricot (prunus mume siebold et zucc.;ume) on helicobacter pylori-related chronic gastritis. Eur J Clin Nutr, 64, 714-9. https://doi.org/10.1038/ejcn.2010.70
  23. Ghazanfar, S.A. Handbook of Arabian Medicinal Plants (1994). CRC Press. Boca Raton, 148.
  24. Gil, MI, Tomas-Barberan, et al (2000). Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem, 48, 4581-9. https://doi.org/10.1021/jf000404a
  25. Gordillo G, Fang H, Khanna S, et al (2009). Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm. Antioxid Redox Signal, 11, 47-58. https://doi.org/10.1089/ars.2008.2150
  26. Gu J, Ahn-Jarvis JH, Riedl KM, et al (2013). Characterization of black raspberry functional food products for cancer prevention human clinical trials. J Agric Food Chem, [Epub ahead of print].
  27. Gunasekera RS, Sewgobind K, Desai S, et al (2007). Lycopene and lutein inhibit proliferation in rat prostate carcinoma cells. Nutr Cancer, 58, 171-7. https://doi.org/10.1080/01635580701328339
  28. Hara S, Morita R, Ogawa T, et al (2014). Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Exp Toxicol Pathol, [Epub ahead of print].
  29. Harris GK, Gupta A, Nines RG, et al (2001). Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2’-deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer, 40, 125-33. https://doi.org/10.1207/S15327914NC402_8
  30. Hazra B, Kumar B, Biswas S, Pandey BN, Mishra KP (2005). Enhancement of the tumour inhibitory activity, in vivo, of diospyrin, a plant-derived quinonoid, through liposomal encapsulation. Toxicol Lett, 157, 109-17. https://doi.org/10.1016/j.toxlet.2005.01.016
  31. Hope Smith S, Tate PL, Huang G, et al (2004). Antimutagenic activity of berry extracts. J Med Food, 7, 450-5. https://doi.org/10.1089/jmf.2004.7.450
  32. Huang JP, Zhang M, Holman CD, Xie X (2007). Dietary carotenoids and risk of breast cancer in Chinese women. Asia Pac J Clin Nutr, 16, 437-42.
  33. Huang MT, Smart RC, Wong CQ, Conney AH (1988). Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res, 48, 5941-6.
  34. Jesionkowska K, Sijtsema S, Simoneaux R, Konopacka D, Plocharski W (2008). Preferences and consumption of dried fruit and dried fruit products among Dutch, French and Polish consumers. J. Fruit Ornament. Plant Res, 16, 261-74.
  35. Johnson JJ, Petiwala SM, Syed DN, et al (2012). alpha-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth. Carcinogenesis, 33, 413-9. https://doi.org/10.1093/carcin/bgr291
  36. Jung HA, Su BN, Keller WJ, Mehta RG, Kinghorn AD (2006). Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric Food Chem, 54, 2077-82. https://doi.org/10.1021/jf052649z
  37. Jung ST, Park YS, Zachwieja Z, et al (2005). Some essential phytochemicals and the antioxidant potential in fresh and dried persimmon. Int J Food Sci Nutr, 56, 105-13. https://doi.org/10.1080/09637480500081571
  38. Karadeniz F, Durst RW, Wrolstad RE (2000). Polyphenolic composition of raisins. J Agric Food Chem, 48, 5343-50. https://doi.org/10.1021/jf0009753
  39. Karakaya S, El SN, Tas AA (2001). Antioxidant activity of some foods containing phenolic compounds. Int J Food Sci Nutr. 52, 501-8. https://doi.org/10.1080/713671810
  40. Kawabata K, Yamamoto T, Hara A, et al (2000). Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Lett, 157, 15-21. https://doi.org/10.1016/S0304-3835(00)00461-4
  41. Khan N, Afaq F, Kweon MH, Kim K, Mukhtar H (2007). Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res, 67, 3475-82. https://doi.org/10.1158/0008-5472.CAN-06-3941
  42. Kim OK, Murakami A, Nakamura Y, et al (2000a). Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit. J Agric Food Chem, 48, 1557-63. https://doi.org/10.1021/jf990977r
  43. Kim OK, Murakami A, Takahashi D, et al (2000b). An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin. Biosci Biotechnol Biochem, 64, 2504-7. https://doi.org/10.1271/bbb.64.2504
  44. Kimura Y, Ito H, Kawaji M, Ikami T, Hatano T (2008). Characterization and antioxidative properties of oligomeric proanthocyanidin from prunes, dried fruit of Prunus domestica L. Biosci Biotechnol Biochem, 72, 1615-8. https://doi.org/10.1271/bbb.70823
  45. Kountouri AM, Gioxari A, Karvela E, et al (2013). Chemopreventive properties of raisins originating from Greece in colon cancer cells. Food & function, 4, 366-72. https://doi.org/10.1039/c2fo30259d
  46. Kresty LA, Morse MA, Morgan C, et al (2001). Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res, 61, 6112-9.
  47. Kundu JK, Surh YJ (2008). Inflammation: gearing the journey to cancer. Mutat Res, 659, 15-30. https://doi.org/10.1016/j.mrrev.2008.03.002
  48. La Vecchia C, Altieri A, Tavani A (2001). Vegetables, fruit, antioxidants and cancer: a review of Italian studies. Eur J Nutr, 40, 261-7. https://doi.org/10.1007/s394-001-8354-9
  49. Lansky EP, Harrison G, Froom P, Jiang WG (2005). Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Investigational new drugs, 23, 121-2. https://doi.org/10.1007/s10637-005-5856-7
  50. Li J, Malakhova M, Mottamal M, et al (2012). Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases. Cancer Res, 72, 260-70. https://doi.org/10.1158/0008-5472.CAN-11-2596
  51. Lin HH, Chen JH, Chou FP, Wang CJ (2011). Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-kappaB pathway and MMP-2 production by targeting RhoB activation. Br J Pharmacol, 162, 237-54. https://doi.org/10.1111/j.1476-5381.2010.01022.x
  52. Lu QY, Arteaga JR, Zhang Q, et al (2005). Inhibition of prostate cancer cell growth by an avocado extract: role of lipidsoluble bioactive substances. J Nutr Biochem, 16, 23-30. https://doi.org/10.1016/j.jnutbio.2004.08.003
  53. Mackay J, Jemal A, Lee N, Parkin D (2006). The Cancer Atlas. American Cancer Society.
  54. Madrigal-Bujaidar E, Martino Roaro L, Garcia-Aguirre K, Garcia-Medina S, Alvarez-Gonzalez I (2013). Grapefruit juice suppresses azoxymethane-induced colon aberrant crypt formation and induces antioxidant capacity in mice. Asian Pac J Cancer Prev. 14, 6851-6. https://doi.org/10.7314/APJCP.2013.14.11.6851
  55. Mahabusarakam W, Kuaha K, Wilairat P, Taylor WC (2006). Prenylated xanthones as potential antiplasmodial substances. Planta Med, 72, 912-6. https://doi.org/10.1055/s-2006-947190
  56. Marques LG, Ferreira MC, Freire JT (2007). Freeze-drying of acerola (Malpighia glabra L.). Chem Eng Process, 46, 451-7. https://doi.org/10.1016/j.cep.2006.04.011
  57. Misikangas M, Pajari AM, Paivarinta E, et al (2007). Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa. J Nutr, 137, 2285-90.
  58. Miyata M, Takano H, Takahashi K, Sasaki YF, Yamazoe Y. (2002). Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine-induced DNA damage in rat colon after grapefruit juice intake. Cancer Lett, 183, 17-22. https://doi.org/10.1016/S0304-3835(02)00109-X
  59. Montrose DC, Horelik NA, Madigan JP, et al (2011). Antiinflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. Carcinogenesis, 32, 343-50. https://doi.org/10.1093/carcin/bgq248
  60. Morgan AF, Kimmel L, Field A, Nichols PF (1935). The vitamin content of sultanina (Thompson seedless) grapes and raisins. J Nutr, 9, 369-82.
  61. Munzuroglu O, Karatas F, Geckil H (2003). The vitamin and selenium contents of apricot fruit of different varieties cultivated in different geographical regions. Food Chem, 83, 205-12. https://doi.org/10.1016/S0308-8146(03)00064-5
  62. Nakamura H, Nishikawa A, Furukawa F, et al (2000). Inhibitory effects of protocatechuic acid on the post-initiation phase of hamster pancreatic carcinogenesis induced by N-nitrosobis (2-oxopropyl)amine. Anticancer Res, 20, 3423-7.
  63. Nakatani K, Yamakuni T, Kondo N, et al (2004). gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. Mol Pharmacol, 66, 667-74. https://doi.org/10.1124/mol.104.002626
  64. Noda Y, Kaneyuki T, Mori A, Packer L (2002). Antioxidant activities of pomegranate fruit extract and its anthocyanidins:delphinidin, cyanidin, and pelargonidin. J Agric Food Chem, 50, 166-71. https://doi.org/10.1021/jf0108765
  65. Ohnishi M, Yoshimi N, Kawamori T, et al (1997). Inhibitory effects of dietary protocatechuic acid and costunolide on 7, 12-dimethylbenz[a]anthracene-induced hamster cheek pouch carcinogenesis. Jpn J Cancer Res, 88, 111-9. https://doi.org/10.1111/j.1349-7006.1997.tb00355.x
  66. Panyathep A, Chewonarin T, Taneyhill K, Vinitketkumnuen U, Surh YJ (2013). Inhibitory effects of dried longan (Euphoria longana Lam.) seed extract on invasion and matrix metalloproteinases of colon cancer cells. J Agric Food Chem, 61, 3631-41. https://doi.org/10.1021/jf3052863
  67. Park OJ, Surh YJ (2004). Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies. Toxicol Lett, 150, 43-56. https://doi.org/10.1016/j.toxlet.2003.06.001
  68. Park S, Bae J, Nam BH, Yoo KY (2008). Aetiology of cancer in Asia. Asian Pac J Cancer Prev, 9, 371-80.
  69. Parker TL1, Wang XH, Pazmino J, Engeseth NJ (2007). Antioxidant capacity and phenolic content of grapes, sundried raisins, and golden raisins and their effect on ex vivo serum antioxidant capacity. J Agric Food Chem, 55, 8472-7. https://doi.org/10.1021/jf071468p
  70. Pedraza-Chaverri J, Cardenas-Rodriguez N, Orozco-Ibarra M, Perez-Rojas JM (2008). Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol, 46, 3227-39. https://doi.org/10.1016/j.fct.2008.07.024
  71. Pellegrini N, Serafini M, Salvatore S, et al (2006). Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays. Mol Nutr Food Res, 50, 1030-8. https://doi.org/10.1002/mnfr.200600067
  72. Piberger H, Oehme A, Hofmann C, et al (2011). Bilberries and their anthocyanins ameliorate experimental colitis. Mol Nutr Food Res. 55, 1724-9. https://doi.org/10.1002/mnfr.201100380
  73. Rajakangas J, Misikangas M, Paivarinta E, Mutanen M (2008). Chemoprevention by white currant is mediated by the reduction of nuclear beta-catenin and NF-kappaB levels in Min mice adenomas. Eur J Nutr, 47, 115-22. https://doi.org/10.1007/s00394-008-0704-0
  74. Rajendran P, Ekambaram G, Sakthisekaran D (2008). Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice. Nat Prod Res, 22, 672-80. https://doi.org/10.1080/14786410701824973
  75. Rangkadilok N, Worasuttayangkurn L, Bennett RN, Satayavivad J (2005). Identification and quantification of polyphenolic compounds in Longan (Euphoria longana Lam.) fruit. J Agric Food Chem, 53, 1387-92. https://doi.org/10.1021/jf0403484
  76. Rankin JW, Andreae MC, Chen CYO, O’Keefe SF (2008). Effect of raisin consumption on oxidative stress and inflammation in obesity. Diabetes Obes Metab, 10, 1086-96. https://doi.org/10.1111/j.1463-1326.2008.00867.x
  77. Ratti C (2001). Hot air and freeze-drying of high-value foods. a review. J Food Eng, 49, 311-9. https://doi.org/10.1016/S0260-8774(00)00228-4
  78. Reddy BS, Engle A, Simi B, et al (1988). Effect of low-fat, high-carbohydrate, high-fiber diet on fecal bile acids and neutral sterols. Prev Med, 17, 432-9. https://doi.org/10.1016/0091-7435(88)90042-4
  79. Reinli K, Block G (1996). Phytoestrogen content of foods--a compendium of literature values. Nutr Cancer, 26, 123-48. https://doi.org/10.1080/01635589609514470
  80. Saleem M, Afaq F, Adhami VM, Mukhtar H (2004). Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene, 23, 5203-14. https://doi.org/10.1038/sj.onc.1207641
  81. Seeram NP, Adams LS, Zhang Y, et al (2006). Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem, 54, 9329-39. https://doi.org/10.1021/jf061750g
  82. Shan T, Ma Q, Guo K, et al (2011). Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med, 11, 666-77. https://doi.org/10.2174/156652411797536679
  83. Shanmugam MK, Manu KA, Ong TH, et al (2011a). Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. Int J Cancer, 129, 1552-63. https://doi.org/10.1002/ijc.26120
  84. Shanmugam MK, Rajendran P, Li F, et al (2011b). Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. J Mol Med (Berl), 89, 713-27. https://doi.org/10.1007/s00109-011-0746-2
  85. Shibata MA, Iinuma M, Morimoto J, et al (2011). alpha-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med, 9, 69. https://doi.org/10.1186/1741-7015-9-69
  86. Shimizu M, Yoshimi N, Yamada Y, et al (1999). Suppressive effects of chlorogenic acid on N-methyl-N-nitrosoureainduced glandular stomach carcinogenesis in male F344 rats. J Toxicol Sci, 24, 433-9. https://doi.org/10.2131/jts.24.5_433
  87. Sindhu ER, Preethi KC, Kuttan R (2010). Antioxidant activity of carotenoid lutein in vitro and in vivo. Indian J Exp Biol, 48, 843-8.
  88. Slatnar A, Klancar U, Stampar F, Veberic R (2011). Effect of drying of figs (Ficus carica L.) on the contents of sugars, organic acids, and phenolic compounds. J Agric Food Chem, 59, 11696-702. https://doi.org/10.1021/jf202707y
  89. Spiller GA, Story JA, Furumoto EJ, Chezem JC, Spiller M (2003). Effect of tartaric acid and dietary fibre from sundried raisins on colonic function and on bile acid and volatile fatty acid excretion in healthy adults. Brit J Nutr, 90, 803-7. https://doi.org/10.1079/BJN2003966
  90. Sporn MB (1976). Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res, 36, 2699-702.
  91. Stacewicz-Sapuntzakis M, Bowen PE, Hussain EA, Damayanti-Wood BI, Farnsworth NR (2001). Chemical composition and potential health effects of prunes: a functional food. Crit Rev Food Sci Nutr, 41, 251-86. https://doi.org/10.1080/20014091091814
  92. Stoner GD, Kresty LA, Carlton PS, Siglin JC, Morse MA (1999). Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer. Toxicol Sci, 52, 95-100. https://doi.org/10.1093/toxsci/52.2.95
  93. Suzuki R, Kohno H, Sugie S, Tanaka T (2003). Dietary protocatechuic acid during the progression phase exerts chemopreventive effects on chemically induced rat tongue carcinogenesis. Asian Pac J Cancer Prev, 4, 319-26.
  94. Tanaka T, Kojima T, Kawamori T, et al (1993). Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids. Carcinogenesis, 14, 1321-5. https://doi.org/10.1093/carcin/14.7.1321
  95. Tanaka T, Maeda M, Kohno H. et al (2001). Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin. Carcinogenesis, 22, 193-8. https://doi.org/10.1093/carcin/22.1.193
  96. Telang M, Dhulap S, Mandhare A, Hirwani R (2013). Therapeutic and cosmetic applications of mangiferin: a patent review. Expert opin ther pat, 23, 1561-80. https://doi.org/10.1517/13543776.2013.836182
  97. Thoppil RJ, Bhatia D, Barnes KF, et al (2012). Black currant anthocyanins abrogate oxidative stress through Nrf2-mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. Curr cancer drug targets, 12, 1244-57.
  98. Tinker LF, Schneeman BO, Davis PA, Gallaher DD, Waggoner CR (1991). Consumption of prunes as a source of dietary fiber in men with mild hypercholesterolemia. Am J Clin Nutr, 53, 1259-65.
  99. Trucksess MW, Scott PM (2008). Mycotoxins in botanicals and dried fruits: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 25, 181-92. https://doi.org/10.1080/02652030701567459
  100. Tsuchiya H, Yamada K, Kato H, et al (1995). High-performance liquid-chromatographic analysis of tetrahydro-betacarbolines in food plants. Phytochem Analysis, 6, 297-301. https://doi.org/10.1002/pca.2800060605
  101. Ullman SB, Clark GM, Roan KM (1952). The effects of the fraction R3 of the latex of ficus carica L. on the tissues of mice bearing spontaneous mammary tumors. Exp Med Surg, 10, 287-305.
  102. Vinson JA, Su X, Zubik L, Bose P (2001). Phenol antioxidant quantity and quality in foods: fruits. J Agric Food Chem, 49, 5315-21. https://doi.org/10.1021/jf0009293
  103. Wattenberg LW, Coccia JB, Lam LK (1980). Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasia. Cancer Res, 40, 2820-3.
  104. Wu X, Beecher GR, Holden JM, et al (2004). Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem, 52, 4026-37. https://doi.org/10.1021/jf049696w
  105. Yang Y, Gallaher DD (2005). Effect of dried plums on colon cancer risk factors in rats. Nutr Cancer, 53, 117-25. https://doi.org/10.1207/s15327914nc5301_14
  106. Yoshimi N, Matsunaga K, Katayama M, et al (2001). The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats. Cancer Lett, 163, 163-70. https://doi.org/10.1016/S0304-3835(00)00678-9
  107. Yurt B, Celik I (2011). Hepatoprotective effect and antioxidant role of sun, sulphited-dried apricot (Prunus armeniaca L.) and its kernel against ethanol-induced oxidative stress in rats. Food Chem Toxicol, 49, 508-13. https://doi.org/10.1016/j.fct.2010.11.035
  108. Zadernowski R, Czaplicki S, Naczk M (2009). Phenolic acid profiles of mangosteen fruits (Garcinia mangostana). Food Chem, 112, 685-9. https://doi.org/10.1016/j.foodchem.2008.06.030
  109. Zhao B, Hall CA (2008). Composition and antioxidant activity of raisin extracts obtained from various solvents. Food Chem, 108, 511-8. https://doi.org/10.1016/j.foodchem.2007.11.003
  110. Zhou C, Sheng Y, Zhao D, Wang Z, Tao J (2010). Variation of oleanolic and ursolic acid in the flesh of persimmon fruit among different cultivars. Molecules, 15, 6580-7. https://doi.org/10.3390/molecules15096580

피인용 문헌

  1. Anti-metastasis Activity of Black Rice Anthocyanins Against Breast Cancer: Analyses Using an ErbB2 Positive Breast Cancer Cell Line and Tumoral Xenograft Model vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6219
  2. Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF-κB-regulated proteins in A549 human lung cancer cells vol.33, pp.3, 2014, https://doi.org/10.3892/or.2014.3658
  3. Different Mechanisms of Seed Kernel Extract from <i>Mangifera indica</i> on the Growth of Two Colon Cancer Cell Lines vol.06, pp.04, 2015, https://doi.org/10.4236/fns.2015.64043
  4. Anti-proliferative and Apoptotic Effects of Dendrosomal Farnesiferol C on Gastric Cancer Cells vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5325
  5. Aloe vera Inhibits Proliferation of Human Breast and Cervical Cancer Cells and Acts Synergistically with Cisplatin vol.16, pp.7, 2015, https://doi.org/10.7314/APJCP.2015.16.7.2939
  6. Anthocyanins From the Fruit of Vitis coignetiae Pulliat Potentiate the Cisplatin Activity by Inhibiting PI3K/Akt Signaling Pathways in Human Gastric Cancer Cells vol.20, pp.1, 2015, https://doi.org/10.15430/JCP.2015.20.1.50
  7. Impact of Anthocyanidins on Mitoxantrone-Induced Cytotoxicity and Genotoxicity vol.15, pp.4, 2016, https://doi.org/10.1177/1534735416628344
  8. L Inhibit Adhesion and EMT of Highly Metastatic Breast Cancer Cells MDA-MB-231 vol.30, pp.7, 2016, https://doi.org/10.1002/ptr.5626
  9. A Comprehensive review of raisins and raisin components and their relationship to human health vol.50, pp.3, 2017, https://doi.org/10.4163/jnh.2017.50.3.203
  10. Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway vol.9, pp.8, 2017, https://doi.org/10.3390/nu9080911