Asian Pacific Journal of Cancer Prevention
- Volume 15 Issue 1
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- Pages.167-174
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- 2014
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- 1513-7368(pISSN)
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- 2476-762X(eISSN)
DOI QR Code
Barbigerone Inhibits Tumor Angiogenesis, Growth and Metastasis in Melanoma
- Yang, Jian-Hong (Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University) ;
- Hu, Jia (Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University) ;
- Wan, Li (State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine, The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Chengdu University of Traditional Chinese Medicine) ;
- Chen, Li-Juan (Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University)
- Published : 2014.01.15
Abstract
Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore investigated the effects of barbigerone on all three in the B16F10 tumor model established in both zebrafish and mouse models, and explored underlying molecular mechanisms. In vitro, barbigerone inhibited B16F10 cell proliferation, survival, migration and invasion and suppressed human umbilical vascular endothelial cell migration, invasion and tube formation in concentration-dependent manners. In the transgenic zebrafish model, treatment with
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Acknowledgement
Supported by : National Natural Science Foundation of China
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