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FOXA1: a Promising Prognostic Marker in Breast Cancer

  • Hu, Qing ;
  • Luo, Zhou ;
  • Xu, Tao ;
  • Zhang, Jun-Ying ;
  • Zhu, Ying ;
  • Chen, Wei-Xian ;
  • Zhong, Shan-Liang ;
  • Zhao, Jian-Hua ;
  • Tang, Jin-Hai
  • Published : 2014.01.15

Abstract

Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers can aid in more accurate prediction of clinical outcome and may also reveal novel predictive factors and therapeutic targets. One such prognostic marker seems to be FOXA1. Many studies have shown that FOXA1 is strongly expressed in a vast majority of cancers, including breast cancer, in which high expression is associated with a good prognosis. In this review, we summarize the role of this transcription factor in the development and prognosis of breast cancer in the hope of providing insights into utility of FOXA1 as a novel biomarker.

Keywords

FOXA1;prognosis;biomarker;breast cancer;systematic review

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