DOI QR코드

DOI QR Code

Synthesis, Anticancer and Antioxidant Activity of Novel 2,4-Disubstituted Thiazoles

  • Received : 2013.08.17
  • Accepted : 2014.02.07
  • Published : 2014.06.20

Abstract

A new series of carbazole based 2,4-disubstituted thiazole derivatives were synthesized. All the synthesized compounds were tested for their cytotoxicity against three different cancer cell lines A549, MCF-7, and HT29. Some of these compounds showed good cytotoxicity. These compounds were also evaluated for antioxidant activity. Compounds 3a, 3b, 3d-f and 3i showed higher antioxidant activity than standard BHT.

Keywords

2,4-Disubstituted thiazole;Carbazole;${\alpha}$-Bromoketone;Cytotoxicity

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