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The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1

  • Harikrishna, Reddy R. ;
  • Kim, Hackyoung ;
  • Noh, Kwangmo ;
  • Kim, Young Jun
  • Received : 2014.03.07
  • Published : 2014.04.30

Abstract

RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.

Keywords

Cardiac hypertrophy;Cell cycle regulation;Neuronal;gene silencing;SCP1;Small CTD phosphatases

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Acknowledgement

Supported by : Konkuk University