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NF-κB in Cellular Senescence and Cancer Treatment

  • Jing, Hua (MKFZ, Charite - Universitatsmedizin Berlin and Max-Delbruck-Centrum for Molecular Medicine) ;
  • Lee, Soyoung (MKFZ, Charite - Universitatsmedizin Berlin and Max-Delbruck-Centrum for Molecular Medicine)
  • Received : 2013.11.25
  • Accepted : 2013.11.28
  • Published : 2014.03.31

Abstract

The NF-${\kappa}B$ pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-${\kappa}B$ in cancer cells, recent findings postulate that NF-${\kappa}B$ participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-${\kappa}B$. In this review, we discuss implications of the NF-${\kappa}B$ signaling pathway in cancer. Particularly, we emphasize the connection of NF-${\kappa}B$ with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-${\kappa}B$ produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.

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