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Preparation of Gemcitabine-Loaded PLLA/Gemcitabine-PLLA Microparticles Using Supercritical Fluid and Their Release Characteristics

초임계 유체를 이용한 젬시타빈 함유 PLLA/젬시타빈-PLLA 미립자의 제조 및 방출 특성

  • Hong, Jin-Hee (Department of Chemical Engineering, The University of Suwon) ;
  • Lim, Giobin (Department of Chemical Engineering, The University of Suwon) ;
  • Ryu, Jong-Hoon (Department of Chemical Engineering, The University of Suwon)
  • Received : 2014.08.29
  • Accepted : 2014.10.28
  • Published : 2014.12.30

Abstract

In this study, gemcitabine (Gem)-Poly(L-lactic acid) (PLLA) conjugates were synthesized through an amide linkage reaction. Then, the microparticles of Gem-PLLA/PLLA blends containing gemcitabine were prepared using a supercritical fluid process, called aerosol solvent extraction system (ASES). Gemcitabine-loaded Gem-PLLA/PLLA microparticles obtained from the ASES process showed a spherical shape. The amount of gemcitabine released after 30 day incubation in a phosphate buffer solution of pH 7.4 was about 90% of the total amount of gemcitabine present in the product.

Acknowledgement

Supported by : 농촌진흥청

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