The Combined Effect of Caffeine and Ornithine on the Mood of Healthy Office Workers

  • Misaizu, Akane (Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd.) ;
  • Kokubo, Takeshi (Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd.) ;
  • Tazumi, Kyoko (Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd.) ;
  • Kanayama, Masaya (Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd.) ;
  • Miura, Yutaka (Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd.)
  • Received : 2014.07.08
  • Accepted : 2014.10.12
  • Published : 2014.12.31


Caffeine is widely consumed and well known for stimulating the central nervous system. When developing new foods and beverages that contain caffeine, it is important to explore the potential synergistic effects of consuming amino acids and other food ingredients with caffeine on humans. Given the physiological pathways affected by the amino acid ornithine, consumption of ornithine with caffeine may have synergistic effects. The purpose of the present study was to examine the effect of consuming caffeine with ornithine in humans. The study used a randomized, placebo-controlled, double-blinded crossover design. The subjects were all healthy office workers who ingested the placebo, 100 mg caffeine, or 100 mg caffeine plus 200 mg ornithine in the morning and completed questionnaires about their mood. Office workers who consumed the combination of caffeine and ornithine had higher mood ratings 8 h after consumption than office workers who consumed caffeine alone. The results of the present study suggest that there is a unique synergistic effect between caffeine and ornithine on the mood of healthy office workers and that ornithine may potentiate the effects of caffeine.


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