- Volume 19 Issue 4
DOI QR Code
Relationship between Blood Mercury Level and Risk of Cardiovascular Diseases: Results from the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) 2008-2009
- Kim, Young-Nam (Department of Food and Nutrition, Duksung Women's University) ;
- Kim, Young A (Department of Food and Nutrition, College of Biotechnology and Natural Resource, Chung-Ang University) ;
- Yang, Ae-Ri (Department of Food and Nutrition, College of Biotechnology and Natural Resource, Chung-Ang University) ;
- Lee, Bog-Hieu (Department of Food and Nutrition, College of Biotechnology and Natural Resource, Chung-Ang University)
- Received : 2014.08.04
- Accepted : 2014.10.12
- Published : 2014.12.31
Limited epidemiologic data is available regarding the cardiovascular effects of mercury exposure. The purpose of this study was to determine the relationship between mercury exposure from fish consumption and cardiovascular disease in a nationally representative sample of Korean adults using the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV 2008~2009). Survey logistic regression models accounting for the complex sampling were used to estimate the odds ratios (OR) adjusted for fish consumption frequency, age, education, individual annual income, household annual income, body mass index (BMI), waist circumference (WC), alcohol consumption status, and smoking status. The mean blood mercury level in the population was
Supported by : Chung-Ang University
- Houston MC. 2007. The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. Altern Ther Health Med 13: S128-S133.
- Guallar E, Sanz-Gallardo MI, van't Veer P, Bode P, Aro A, Gomez-Aracena J, Kark JD, Riemersma RA, Martin-Moreno JM, Kok FJ. 2002. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med 347: 1747-1754. https://doi.org/10.1056/NEJMoa020157
- Salonen JT, Seppanen K, Lakka TA, Salonen R, Kaplan GA. 2000. Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland. Atherosclerosis 148: 265-273. https://doi.org/10.1016/S0021-9150(99)00272-5
- Houston MC. 2011. Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. J Clin Hypertens (Greenwich) 13: 621-627. https://doi.org/10.1111/j.1751-7176.2011.00489.x
- Wennberg M, Bergdahl IA, Stegmayr B, Hallmans G, Lundh T, Skerfving S, Stromberg U, Vessby B, Jansson JH. 2007. Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden. Br J Nutr 98: 1038-1045.
- Smith KM, Barraj LM, Kantor M, Sahyoun NR. 2009 Relationship between fish intake, n-3 fatty acids, mercury and risk markers of CHD (National Health and Nutrition Examination Survey 1999-2002). Public Health Nutr 12: 1261-1269. https://doi.org/10.1017/S1368980008003844
- Kris-Etherton PM, Harris WS, Appel LJ. 2003. Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 23: 151-152. https://doi.org/10.1161/01.ATV.0000057393.97337.AE
- Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K. 2007. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369: 1090-1098. https://doi.org/10.1016/S0140-6736(07)60527-3
- Alissa EM, Ferns GA. 2011. Heavy metal poisoning and cardiovascular disease. J Toxicol 2011: 870125.
- Abelsohn A, Vanderlinden LD, Scott F, Archbold JA, Brown TL. 2011. Healthy fish consumption and reduced mercury exposure: counseling women in their reproductive years. Can Fam Physician 57: 26-30.
- Counter SA, Buchanan LH. 2004. Mercury exposure in children: a review. Toxicol Appl Pharmacol 198: 209-230. https://doi.org/10.1016/j.taap.2003.11.032
- Bose-O'Reilly S, McCarty KM, Steckling N, Lettmeier B. 2010. Mercury exposure and children's health. Curr Probl Pediatr Adolesc Health Care 40: 186-215. https://doi.org/10.1016/j.cppeds.2010.07.002
- Myers GJ, Davidson PW, Strain JJ. 2007. Nutrient and methyl mercury exposure from consuming fish. J Nutr 137: 2805-2808.
- Hong YS, Kim YM, Lee KE. 2012. Methylmercury exposure and health effects. J Prev Med Public Health 45: 353-363. https://doi.org/10.3961/jpmph.2012.45.6.353
- Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, Spiegelman D, Stampfer MJ, Willett WC. 2002. Mercury and the risk of coronary heart disease in men. N Engl J Med 347: 1755-1760. https://doi.org/10.1056/NEJMoa021437
- Korea Centers for Disease Control and Prevention. 2012. The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3), 2008-2009.
- Mahaffey KR, Clickner RP, Bodurow CC. 2004. Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000. Environ Health Perspect 112: 562-570.
- United States Environmental Protection Agency 2012. How people are exposed to mercury. http://www.epa.gov/mercury/exposure.htm (accessed Mar 2012).
- Kim NS, Lee BK. 2010. Blood total mercury and fish consumption in the Korean general population in KNHANES III, 2005. Sci Total Environ 408: 4841-4847. https://doi.org/10.1016/j.scitotenv.2010.06.026
- You CH, Kim BG, Kim JM, Yu SD, Kim YM, Kim RB, Hong YS. 2011. Relationship between blood mercury concentration and waist-to-hip ratio in elderly Korean individuals living in coastal areas. J Prev Med Public Health 44: 218-225. https://doi.org/10.3961/jpmph.2011.44.5.218
- Lincoln RA, Shine JP, Chesney EJ, Vorhees DJ, Grandjean P, Senn DB. 2011. Fish consumption and mercury exposure among Louisiana recreational anglers. Environ Health Perspect 119: 245-251. https://doi.org/10.1289/ehp.119-a245
- Jeejeebhoy KN. 2008. Benefits and risks of a fish diet-should we be eating more or less? Nat Clin Pract Gastroenterol Hepatol 5: 178-179.
- Mahaffey KR, Clickner RP, Jeffries RA. 2009. Adult women's blood mercury concentrations vary regionally in the United States: association with patterns of fish consumption (NHANES 1999-2004). Environ Health Perspect 117: 47-53. https://doi.org/10.1289/ehp.11674
- Smith KM, Barraj LM, Kantor M, Sahyoun NR. 2009. Relationship between fish intake, n-3 fatty acids, mercury and risk markers of CHD (National Health and Nutrition Examination Survey 1999-2002). Public Health Nutr 12: 1261-1269. https://doi.org/10.1017/S1368980008003844
- Joo HJ, Noh MJ, Yoo JH, Jang YM, Park JS, Kang MH, Kim M. 2010. Monitoring total mercury and methylmercury in commonly consumed aquatic foods. Korean J Food Sci Technol 42: 269-276.
- Sizer F, Whiteny E. 2013. Nutrition: Concepts and Controversies. 13th ed. Cengage Learning, Independence, KY, USA. p 177-178.
- Mozaffarian D, Shi P, Morris JS, Spiegelman D, Grandjean P, siscovick DS, Willett WC, Rimm EB. 2011. Mercury exposure and risk of cardiovascular disease in two U.S. cohorts. N Engl J Med 364: 1116-1125. https://doi.org/10.1056/NEJMoa1006876
- Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, Korhonen MJ, Valkonen VP, Seppanen K, Laukkanen JA, Salonen JT. 2005. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arterioscler Thromb Vasc Biol 25: 228-233.
- Choi AL, Weihe P, Budtz-Jorgensen E, Jorgensen PJ, Salonen JT, Tuomainen TP, Murata K, Nielsen HP, Petersen MS, Askham J, Grandjean P. 2009. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect 117: 367-372. https://doi.org/10.1289/ehp.11608
- Yorifuji T, Tsuda T, Kashima S, Takao S, Harada M. 2010. Long-term exposure to methylmercury and its effects on hypertension in Minamata. Environ Res 110: 40-46. https://doi.org/10.1016/j.envres.2009.10.011
- Valera B, Dewailly E, Poirier P. 2011. Impact of mercury exposure on blood pressure and cardiac autonomic activity among Cree adults (James Bay, Quebec, Canada). Environ Res 111: 1265-1270. https://doi.org/10.1016/j.envres.2011.09.001
- Rissanen T, Voutilainen S, Nyyssonen K, Lakka TA, Salonen JT. 2000. Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study. Circulation 102: 2677-2679. https://doi.org/10.1161/01.CIR.102.22.2677
- Fillion M, Mergler D, Sousa Passos CJ, Larribe F, Lemire M, Guimaraes JR. 2006. A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon. Environ Health 5: 29. https://doi.org/10.1186/1476-069X-5-29
- Superoxide anion generation and oxidative stress in methylmercury-induced endothelial toxicity in vitro vol.38, 2017, https://doi.org/10.1016/j.tiv.2016.10.010
- Fish consumption, mercury exposure, and the risk of cholesterol profiles: findings from the Korea National Health and Nutrition Examination Survey 2010-2011 vol.32, 2017, https://doi.org/10.5620/eht.e2017014
- Screening of Blood Levels of Mercury, Cadmium, and Copper in Pregnant Women in Dakahlia, Egypt: New Attention to an Old Problem vol.171, pp.2, 2016, https://doi.org/10.1007/s12011-015-0525-y
- Associations of serum n-3 and n-6 PUFA and hair mercury with the risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) vol.115, pp.10, 2016, https://doi.org/10.1017/S0007114516000982
- Mercury, selenium and fish oils in marine food webs and implications for human health vol.96, pp.01, 2016, https://doi.org/10.1017/S0025315415001356
- Lean Fish Consumption Is Associated with Beneficial Changes in the Metabolic Syndrome Components: A 13-Year Follow-Up Study from the Norwegian Tromsø Study vol.9, pp.3, 2017, https://doi.org/10.3390/nu9030247
- An analysis of factors affecting the mercury content in the human femoral bone vol.24, pp.1, 2017, https://doi.org/10.1007/s11356-016-7784-9
- Cerebrovascular endothelial dysfunction induced by mercury exposure at low concentrations vol.53, 2016, https://doi.org/10.1016/j.neuro.2016.02.010
- Association between Blood Mercury Level and Visceral Adiposity in Adults vol.41, pp.2, 2017, https://doi.org/10.4093/dmj.2017.41.2.113
- The Association Between Blood Mercury Levels and Risk for Overweight in a General Adult Population: Results from the Korean National Health and Nutrition Examination Survey vol.171, pp.2, 2016, https://doi.org/10.1007/s12011-015-0530-1
- Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study vol.17, pp.1, 2017, https://doi.org/10.1186/s12872-016-0435-8
- Association between heavy metal levels and acute ischemic stroke vol.25, pp.1, 2018, https://doi.org/10.1186/s12929-018-0446-0