- Volume 15 Issue 21
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Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study
- Guettiti, Haifa (Department of Pathology, Faculty of Medicine, Institut Pasteur de Tunis) ;
- Ennaifer, Emna (Department of Pathology, Faculty of Medicine, Institut Pasteur de Tunis) ;
- Attia, Leila (Department of Gynecology Charles Nicolle Hospital Tunis) ;
- Chelly, Dalenda (Department of Gynecology Centre de maternite et de Neonatologie Tunis) ;
- Alaya, Nissaf Ben (Department of Epidemiology, Observatoire National de Tunis) ;
- Aissa, Rim Ben (Family Planning Clinic of Ariana Tunis) ;
- Laassili, Thalja (Department of Pathology, Faculty of Medicine, Institut Pasteur de Tunis) ;
- Boubaker, Samir (Department of Pathology, Faculty of Medicine, Institut Pasteur de Tunis)
- Published : 2014.11.28
Background: To estimate the pre-vaccination distribution of human papillomavirus (HPV) types among women from urban Tunis. Materials and Methods: A total of 611 women aged 18-69 years were enrolled in three local gynaecological outpatient departments. All underwent a gynaecological examination with Pap test and dry swab for HPV detection and typing performed by linear array genotyping test (Roche). Cytological examination was conducted on conventional Pap smears. Results: HPV DNA was found in 6.5% of the women; the most frequent HPV types were HPV 16 and HPV 11 at 3.27% and 1.96%, respectively. The second most frequent high risk (HR) HPV type was HPV 58 (0.82%) followed by HPV 18, HPV 31 and HPV 33 found in only 0.33% of women. Single infections with HPV types, targeted by the quadrivalent vaccine (6, 11, 16, and 18), were detected in 3.6 % of the study patients (55% of positive women). HPV infection was found in 3.83% of women with normal cytology and in 47.4% of women with cytological abnormalities. No statistically significant trend in prevalence by age group emerged for any HPV type or for high or low risk types. Conclusions: These data show a relatively low prevalence of HPV infection in women from urban Tunis with a high proportion of HPV16 and HPV58. This should be considered in the upcoming screening programs and vaccination strategy.
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- Prevalence, Genotype Distribution and Risk Factors for Cervical Human Papillomavirus Infection in the Grand Tunis Region, Tunisia vol.11, pp.6, 2016, https://doi.org/10.1371/journal.pone.0157432