- Volume 15 Issue 21
DOI QR Code
Folate Deficiency and FHIT Hypermethylation and HPV 16 Infection Promote Cervical Cancerization
- Bai, Li-Xia (Maternal and Children Health care of Shanxi Province affiliated to Shanxi Medical University) ;
- Wang, Jin-Tao (Department of Epidemiology, School of Public Health, Shanxi Medical University) ;
- Ding, Ling (Department of Epidemiology, School of Public Health, Shanxi Medical University) ;
- Jiang, Shi-Wen (Department of Biomedical Science, Mercer University School of Medicine) ;
- Kang, Hui-Jie (Department of Epidemiology, School of Public Health, Shanxi Medical University) ;
- Gao, Chen-Fei (Department of Epidemiology, School of Public Health, Shanxi Medical University) ;
- Chen, Xiao (Department of Epidemiology, School of Public Health, Shanxi Medical University) ;
- Chen, Chen (Department of Epidemiology, School of Public Health, Shanxi Medical University) ;
- Zhou, Qin (Department of Epidemiology, School of Public Health, Shanxi Medical University)
- Published : 2014.11.28
Fragile histidine triad (FHIT) is a suppressor gene related to cervical cancer through CpG island hypermethylation. Folate is a water-soluble B-vitamin and an important cofactor in one-carbon metabolism. It may play an essential role in cervical lesions through effects on DNA methylation. The purpose of this study was to observe effects of folate and FHIT methylation and HPV 16 on cervical cancer progression. In this study, DNA methylation of FHIT, serum folate level and HPV16 status were measured using methylation-specific polymerase chain reaction (MSP), radioimmunoassay (RIA) and polymerase chain reaction (PCR), respectively, in 310 women with a diagnosis of normal cervix (NC, n=109), cervical intraepithelial neoplasia (CIN, n=101) and squamous cell carcinoma of the cervix (SCC, n=101). There were significant differences in HPV16 status (
Supported by : National Natural Science Foundation of China, Natural Science Foundation of Shanxi Province
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