- Volume 15 Issue 21
DOI QR Code
Adherence to Capecitabine Treatment and Contributing Factors among Cancer Patients in Malaysia
Zahrina, Abdul Kadir;Norsa'adah, Bachok;Hassan, Norul Badriah;Norazwany, Yaacob;Norhayati, Md Isa;Roslan, Mohd Haron;Wan Nazuha, Wan Rusik
- Published : 2014.11.28
Ensuring adherence to chemotherapy is important to prevent disease progression, prolong survival and sustain good quality of life. Capecitabine is a complex chemotherapeutic agent with many side effects that might affect patient adherence to treatment. This cross sectional study aimed to determine adherence to capecitabine and its contributing factors among cancer outpatients in Malaysia. One hundred and thirteen patients on single regime capecitabine were recruited from Hospital Sultan Ismail and Hospital Kuala Lumpur from October 2013 to March 2014. Adherence was determined based on adherence score using validated Medication Compliance Questionnaire. Patient socio-demographics, disease, and treatment characteristics were obtained from medical records. Satisfaction score was measured using the validated Patient Satisfaction with Healthcare questionnaire. The mean adherence score was 96.1% (standard deviation: 3.29%). The significant contributing factors of adherence to capecitabine were Malay ethnicity [
- Ahmad NS, Ramli A, Islahudin F, Paraidathathu T (2013). Medication adherence in patients with type 2 diabetes mellitus treated at primary health clinics in Malaysia. Patient Prefer Adherence, 7, 525-30.
- AlGhurair SA, Hughes CA, Simpson SH, Guirguis LM (2012). A systematic review of patient self reported barriers of adherence to antihypertensive medications using the World Health Organization Multidimensional Adherence Model. J Clin Hypertens, 14, 877-86. https://doi.org/10.1111/j.1751-7176.2012.00699.x
- Atkins L, Fallowfield L (2006). Intentional and non-intentional non-adherence to medication amongst breast cancer patients. Eur J Cancer, 42, 2271-6. https://doi.org/10.1016/j.ejca.2006.03.004
- Bhattacharya D, Easthall C, Willoughby KA, Small M, Watson S (2012). Capecitabine non-adherence: exploration of magnitude, nature and contributing factors. J Oncol Pharm Pract, 18, 333-42. https://doi.org/10.1177/1078155211436022
- Cramer JA (1998). Enhancing patient compliance in the elderly. Role of packaging aids and monitoring. Drugs Aging, 12, 7-15. https://doi.org/10.2165/00002512-199812010-00002
- Cramer JA, Roy A, Burrell A, et al (2008). Medication compliance and persistence: terminology and definitions. Value in Health, 11, 44-7. https://doi.org/10.1111/j.1524-4733.2007.00213.x
- DiMatteo MR (2004). Social support and patient adherence to medical treatment: a meta-analysis. Health Psychol, 23, 207-18. https://doi.org/10.1037/0278-6188.8.131.52
- Dusing R (2001). Adverse events, compliance, and changes in therapy. Curr Hypertens Rep, 3, 488-92. https://doi.org/10.1007/s11906-001-0011-0
- Hassan NB, Hasanah CI, Foong K, et al (2006). Identification of psychosocial factors of noncompliance in hypertensive patients. J Hum Hypertens, 20, 23-9. https://doi.org/10.1038/sj.jhh.1001930
- Krolop L, Ko YD, Schwindt PF, et al (2013). Adherence management for patients with cancer taking capecitabine: a prospective two-arm cohort study. BMJ Open, 3.
- Lim GCC, Yahaya H, Lim TO (2002). The First Report of the National Cancer Registry: Cancer Incidence in Malaysia 2002 Ministry of Health, Malaysia, Kuala Lumpur.
- Omar ZA, Tamin NSI (2007). National Cancer Registry Report: Malaysia Cancer Statistics - Data and Figure 2007, Ministry of Health Malaysia, Putrajaya.
- Omar ZA, Ali ZM, Tamin NSI (2006). Malaysia Cancer Statistics- Data and Figure (Peninsular Malaysia) 2006, Ministry of Health, Malaysia, Putrajaya.
- Partridge AH, Archer L, Kornblith AB, et al (2010). Adherence and persistence with oral adjuvant chemotherapy in older women with early-stage breast cancer in CALGB 49907: adherence companion study 60104. J Clin Oncol, 28, 2418-22. https://doi.org/10.1200/JCO.2009.26.4671
- Payne SA (1992). A study of quality of life in cancer patients receiving palliative chemotherapy. Soc Sci Med, 35, 1505-9. https://doi.org/10.1016/0277-9536(92)90053-S
- Ramli A, Ahmad NS, Paraidathathu T (2012). Medication adherence among hypertensive patients of primary health clinics in Malaysia. Patient Prefer Adherence, 6, 613-22.
- Roche (2014). Xeloda: Indications. [Online] Available from:http://www.xeloda.com/hcp/# [Accessed February 3rd].
- Roder DM, de Silva P, Zorbas HN, et al (2012). Adherence to recommended treatments for early invasive breast cancer: decisions of women attending surgeons in the breast cancer audit of Australia and New Zealand. Asian Pac J Cancer Prev, 13, 1675-82. https://doi.org/10.7314/APJCP.2012.13.4.1675
- Ruddy K. Mayer E, Partridge A (2009). Patient adherence and persistence with oral anticancer treatment. CA Cancer J Clin, 59, 56-66. https://doi.org/10.3322/caac.20004
- Sabate E (2003). World Health Organization: Adherence to Long Term Therapies: Evidence for Action, World Health Oraganization, Geneva.
- Spoelstra SL, Given CW (2011). Assessment and measurement of adherence to oral antineoplastic agents. Semin Oncol Nurs, 27, 116-32. https://doi.org/10.1016/j.soncn.2011.02.004
- Staddon AP (2011). Challenges of ensuring adherence to oral therapy in patients with solid malignancies. Comm Oncol, 8, 246.
- Stiggelbout A M, De Haes J (2001). Patient preference for cancer therapy: an overview of measurement approaches. J Clin Oncol, 19, 220-30.
- Thivat E, Van Praagh I, Belliere A, et al (2013). Adherence with oral oncologic treatment in cancer patients: interest of an adherence score of all dosing errors. Oncol, 84, 67-74. https://doi.org/10.1159/000342087
- Twelves C, Wong A, Nowacki MP, et al (2005). Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med, 352, 2696-704. https://doi.org/10.1056/NEJMoa043116
- Verbrugghe M, Verhaeghe S, Lauwaert K, Beeckman D, Van Hecke A (2013). Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: a systematic review. Cancer Treat Rev, 39, 610-21. https://doi.org/10.1016/j.ctrv.2012.12.014
- Walko CM, Lindley C (2005). Capecitabine: a review. Clin Ther, 27, 23-44. https://doi.org/10.1016/j.clinthera.2005.01.005
- WHO (2013). WHO: Cancer. [Online] Available from: http://www.who.int/cancer/en/ [Accessed 28 September].
- Winterhalder R, Hoesli P, Delmore G, et al (2011). Self-reported compliance with capecitabine: findings from a prospective cohort analysis. Oncol, 80, 29-33. https://doi.org/10.1159/000328317
- Prevention of Nausea and Vomiting: Methods and Utility after Surgery in Cancer Patients? vol.16, pp.7, 2015, https://doi.org/10.7314/APJCP.2015.16.7.2629
- Adherence assessment of patients with metastatic solid tumors who are treated in an oncology group practice vol.5, pp.1, 2016, https://doi.org/10.1186/s40064-016-1851-z