- Volume 15 Issue 21
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Influence of Ethnicity on Survival of Breast Cancer Patients in Turkey
- Kuzhan, Abdurahman (Department of Radiation Oncology, Faculty of Medicine, University of Gaziantep) ;
- Adli, Mustafa (University of Marmara) ;
- Buyukhatipoglu, Hakan (Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep)
- Published : 2014.11.28
Background: Kurdish women with breast cancer have more unfavorable prognostic factors than their Turkish and Arab counterparts. However, the effects of these factors on breast cancer survival among these ethnic groups remain unclear. We therefore investigated the impact of ethnicity on survival in breast cancer patients in Turkey. Materials and Methods: Ethnicity, age, stage at diagnosis, tumor characteristics, treatments given (surgery, chemotherapy, radiotherapy and hormone therapy), and survival times were recorded. Kaplan-Meier analysis was used to estimate the overall survival times and survival plots. Log-rank test was used to compare the survival curves.Results: Of the 723 breast cancer patients included in the study, 496 (68.7%) were Turkish, 189 (26.2%) were Kurdish, 37 (5.1%) were Arabic and 1 was Armenian. Kurdish women with breast cancer had larger tumor sizes and higher rates of hormone receptor negative tumors than Turkish and Arab patients. Mean follow-up time was 118.4 [95% Confidence Interval (CI): 95.4-141.3] months, and it was 129.9 (95% CI: 93.7-166.2), 124.2 (95% CI: 108.4-140.1) and 103.1 (95% CI: 85.9-120.4) months for Turkish, Arabic and Kurdish patients, respectively. Conclusions: Kurdish ethnicity is associated with higher rates of hormone receptor negative and triple-negative tumors and with worse survival. Clinical and epidemiological research is warranted to elucidate reasons underlying overall survival, variations in tumor biology, differences in treatment responsiveness, and effects of social factors among ethnic groups in Turkey.
- Abdullah NA, Wan Mahiyuddin WR, Muhammad NA et al (2013) Survival rate of breast cancer patients in Malaysia: a population-based study. Asian Pac J Cancer Prev, 14, 4591-4. https://doi.org/10.7314/APJCP.2013.14.8.4591
- Adli M, Kuzhan A, Alkis H, Dirier A (2010). Assessment of the relationship between clinical and socioeconomic/cultural characteristics of the breast cancer patients. In: 'Abstract Book of 9th National meeting of radiation oncology', (Ed) Akyol F. Miki Publications, Ankara pp.179.
- Amend K, Hicks D, Ambrosone CB (2006). Breast cancer in African-American women: differences in tumor biology from Europan-American women. Cancer Res, 66, 8327-30. https://doi.org/10.1158/0008-5472.CAN-06-1927
- Andaya AA, Enewold L, Horner MJ et al (2012). Socioeconomic disparities and breast cancer hormone receptor status. Cancer Causes Control, 23, 951-8. https://doi.org/10.1007/s10552-012-9966-1
- Bhoo-Pathy N, Hartman M, Yip CH et al (2012). Ethnic differences in survival after breast cancer in South East Asia. PLoS One, 7, 30995. https://doi.org/10.1371/journal.pone.0030995
- Bradley CJ, Given CW, Roberts C (2002). Race, socioeconomic status, and breast cancer treatment and survival. J Natl Cancer Inst, 94, 490-6. https://doi.org/10.1093/jnci/94.7.490
- Brawley OW (2002). Disaggregating the effects or race and poverty on breast cancer outcomes. J Natl Cancer Inst, 94, 471-3. https://doi.org/10.1093/jnci/94.7.471
- Fan L, Goh BC, Wong CI et al (2008). Genotype of human carbonyl reductase CBR3 corralates with doxorubicin disposition and toxicity. Pharmacogenet Genomics, 18, 623-31. https://doi.org/10.1097/FPC.0b013e328301a869
- Gordon NH (2003). Socioeconomic factors and breast cancer in black and white Americans. Cancer Metastasis Rev, 22, 55-65. https://doi.org/10.1023/A:1022212018158
- Greend MA, Pai M (2008). Social determinants of Black-White disparities in breast cancer mortality: a review. Cancer Epidemiol Biomarkers Prev, 17, 2913-23. https://doi.org/10.1158/1055-9965.EPI-07-0633
- Harris L, Fritsche H, Mennel R et al (2007). American society of clinical oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol, 25, 5287-312. https://doi.org/10.1200/JCO.2007.14.2364
- Hersman D, McBride R, Jacobson JS et al (2005). Racial disparities in treatment and survival among women with early-stage breast cancer. J Clin Oncol, 23, 6639-46. https://doi.org/10.1200/JCO.2005.12.633
- Kuzhan A, Adli M, Alkis HE, Caglayan D (2013). Hormone receptor status and HER2 status in patients with breast cancer by races in southeastern Turkey. J BUON, 18, 619-22.
- Kroman N, Wohlfahrt J, Andersen KW et al (1998). Parity, age at first childbirth and the prognosis of primary breast cancer. Br J Cancer, 78, 1529-33. https://doi.org/10.1038/bjc.1998.718
- Lal S, Wong ZW, Jada SR et al (2007). Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients. Pharmacogenomics, 8, 567-75. https://doi.org/10.2217/14622418.104.22.1687
- Li CI, Malone KE, Daling JR (2002). Differences in breast cancer hormone receptor status and histology by race and ethnicity among women 50 years of age and older. Cancer Epidemiol Biomarkers Prev, 11, 601-7.
- Li CI, Malone KE, Daling JR (2003). Differences in breast cancer stage, treatment, and survival by race and ethnicity. Arch Intern Med, 163, 49-56. https://doi.org/10.1001/archinte.163.1.49
- Ma BBY, Hui EP, Mok TSK (2010). Population based differences in treatment outcome following anticancer drug therapies. Lancet Oncol, 11, 75-84. https://doi.org/10.1016/S1470-2045(09)70160-3
- McKenzie F, Jeffreys M (2009). Do lifestyle or social factors explain ethnic/racial inequalities in breast cancer survival? Epidemiol Rev, 31, 52-66. https://doi.org/10.1093/epirev/mxp007
- Newman LA, Mason J, Cote D et al (2002). African American ethnicity, socioeconomic status, and breast cancer survival: a meta-analysis of 14 studies involving over 10,000 African-American and 40,000 White American patients with carcinoma of the breast. Cancer, 94, 2844-54. https://doi.org/10.1002/cncr.10575
- Ozmen V (2008). Breast cancer in the world and Turkey. J Breast Health, 4, 7-12.
- Reynolds P, Hurley S, Torres M et al (2000). Use of coping strategies and breast cancer survival: result from the black/white cancer survival study. Am J Epidemiol, 152, 940-9. https://doi.org/10.1093/aje/152.10.940
- Rosenberg J, Chia YL, Plevritis S (2005). The effect of age, race, tumor size, tumor grade, and disease stage on invasive ductal breast cancer survival in the SEER database. Cancer Res Treat, 89, 47-54. https://doi.org/10.1007/s10549-004-1470-1
- Schootman M, Jeffe DB, Reschke AH, Aft RL (2003). Disparities related to socioeconomic status and access to medical care remain in the United States among women who never had a mammogram. Cancer Causes Control, 14, 419-25. https://doi.org/10.1023/A:1024941626748
- Soler-Vila H, Kasl SV, Jones BA (2003). Prognostic significance of pyhsicosocial factors in African and white breast cancer patients. Cancer, 98, 1299-308. https://doi.org/10.1002/cncr.11670
- Spallek J, Arnold M, Razum O et al (2012). Cancer mortality pattern among Turkish immigrants in four Europan countries and in Turkey. Eur J Epidemiol, 27, 915-21. https://doi.org/10.1007/s10654-012-9746-y
- Telli ML, Chang ET, Kurian AW et al (2011). Asian ethnicity and breast cancer subtypes: a study from the california cancer registry. Breast Cancer Res Treat, 127, 471-8. https://doi.org/10.1007/s10549-010-1173-8
- Wojcik BE, Spinks MK, Optenberg SA (1998). Breast carcinoma survival analysis for African American and white women in an equal-access health care system. Cancer, 82, 1310-8. https://doi.org/10.1002/(SICI)1097-0142(19980401)82:7<1310::AID-CNCR14>3.0.CO;2-9
- Yip CH, Taib N, Mohamed I (2006). Epidemiology of breast cancer in Malaysia. Asian Pac J Cancer Prev, 7, 369.
- Yusuf A, Ab Hadi IS, Mahamood Z et al (2013). Understanding the breast cancer experience: a qualitative study of Malaysian women. Asian Pac J Cancer Prev, 14, 3689-98. https://doi.org/10.7314/APJCP.2013.14.6.3689
- Zeeb H, Razum O (2003). Krebshaufigkeit bei turkischen Staatsburgern in Deutschland. Forum DKG, 2, 42-5.