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Polymorphic Variation of Inflammation-related Genes and Risk of Non-Hodgkin Lymphoma for Uygur and Han Chinese in Xinjiang

  • Gu, Xia (Department of Pathology, The First Affiliated Hospital, Guangzhou Medical University) ;
  • Shen, Yan (Department of Pathology, The Fourth Affiliated Hospital, Guangzhou Medical University) ;
  • Fu, Ling (Department of Hematology, People's Hospital of Xinjiang Uygur Autonomous Region) ;
  • Zuo, Hong-Yun (Institute of Clinical Medicine, Urumqi General Hospital of Lanzhou Command, PLA) ;
  • Yasen, Halida (Department of Hematology, The First Affiliated Hospital, Xinjiang Medical University) ;
  • He, Ping (Department of Pathology, The First Affiliated Hospital, Guangzhou Medical University) ;
  • Guo, Xin-Hong (Department of Hematology, The First Affiliated Hospital, Xinjiang Medical University) ;
  • Shi, Yu-Wei (Department of Hematology, The Second Affiliated Hospital, Xinjiang Medical University) ;
  • Yusufu, Muhabaiti (Department of Pathology, The Second Affiliated Hospital, Xinjiang Medical University)
  • Published : 2014.11.28

Abstract

Polymorphisms of inflammation-related genes have been found to be associated with non-Hodgkin lymphoma (NHL) or some of its subtypes, but only a few relevant data have been reported in China. In this study, the Snapshot method was used to assess genetic variation; a total of 14 single nucleotide polymorphisms (SNPs) for 6 inflammatory factors in 157 NHL cases (64 Uygur ethnic subjects, 93 Han Chinese) and 435 controls (231 Uygur and 204 Han Chinese) were studied from the Xinjiang province of China. Haplotype distribution was estimated using PHASE 2.3 software. Statistical differences in the genotype and haplotype frequencies between case and control groups were also considered and estimated. For the Han population, the geneotype distributions for TNF-${\alpha}rs1800629$, TNF-${\alpha}rs1800630$, IL-6 rs1800795, IL-6 rs1800797, NF-KB1 rs1585215 and TLR-4 rs4986790 showed significant differences between the case and control groups (p<0.05). The TNF-${\alpha}$ gene frequencies of ACG and CCA haplotypes in the cases were higher than in the controls (OR=2.45, 95% CI: 1.55-3.89, p=0.0002, OR=2.53, 95% CI: 1.10-5.80, p=0.029, respectively), and the same findings were detected for TNF-${\beta}$ gene CA haplotype (OR=1.87, 95% CI: 1.21-2.90, p=0.0054). However, for the Uygur population, no such significant differences were detected within the gene-type distribution of the 14 SNPs. The TNF-${\alpha}$ gene frequency of the CCA haplotype between the two groups (OR=1.98, 95% CI: 1.11-3.51, p=0.021) revealed a statistically significant difference. Our results showed that polymorphic variations of inflammation-related genes could be important to the NHL etiology of the Han population, and that these may only have limited influence on the Uygur population.

Acknowledgement

Supported by : National Natural Scientific Foundation of China

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