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Overexpression and Clinicopathological Contribution of DcR3 in Bladder Urothelial Carcinoma Tissues

  • Jiang, Yi-Qiang ;
  • Zhong, Teng-Fei ;
  • Dang, Yi-Wu ;
  • Zou, Ling-Song ;
  • Yang, Liu ;
  • Yang, Xia ;
  • Chen, Gang
  • Published : 2014.11.28

Abstract

Background: To explore the expression of DcR3 protein and its clinicopathological significance in bladder urothelial carcinomas (BUC). Materials and Methods: Immunohistochemistry was performed to detect the expression of DcR3, caspase-3, Bcl-2, VEGF, Ki-67, PCNA and P53 in 166 BUC and 56 normal bladder tissues. Western blotting was used to detect the expression of DcR3 in the supernatants of cultured BUC cells. Results: Overexpression of DcR3 was found in BUC tissues and cell lines, with significant elevation as compared to normal bladder tissues (p<0.0001). Higher DcR3 expression was related to the status of invasion, lymph node metastasis and recurrence. Furthermore, DcR3 expression was negatively correlated with caspase-3 and positively associated with Bcl-2, VEGF, Ki-67 labeling index (LI), PCNA LI and P53 (all p<0.0001), respectively. Conclusions: DcR3 may play a crucial role as an oncogene in tumorigenesis, deterioration and progress of BUC via influencing related pathways of apoptosis, proliferation and angiogenesis. The detection of DcR3 protein in the formalinfixed and paraffin-embedded samples could assist to predict in prognosis of BUC patients.

Keywords

DcR3;BUC;tumorigenesis;invasion;metastasis;recurrence

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Cited by

  1. Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions vol.24, pp.1, 2017, https://doi.org/10.1186/s12929-017-0347-7

Acknowledgement

Supported by : Guangxi Zhuang Autonomous Region University