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microRNA-29b: an Emerging Player in Human Cancer

  • Liu, Hao (Department of Pathology, Nanfang Hospital & School of Basic Medical Sciences, Southern Medical University) ;
  • Wang, Bin (Department of Pathology, Nanfang Hospital & School of Basic Medical Sciences, Southern Medical University) ;
  • Lin, Jie (Department of Pathology, Nanfang Hospital & School of Basic Medical Sciences, Southern Medical University) ;
  • Zhao, Liang (Department of Pathology, Nanfang Hospital & School of Basic Medical Sciences, Southern Medical University)
  • Published : 2014.11.28

Abstract

MicroRNAs (miRNAs) are ubiquitously expressed small, non-coding RNAs that negatively regulate gene expression at a post transcriptional/translational level. They have emerging as playing crucial roles in cancer at all stages ranging from initiation to metastasis. As a tumor suppressor miRNA, aberrant expression of microRNA-29b (miR-29b) has been detected in various types of cancer, and its disturbance is related with tumor development and progression. In this review, we summarize the latest findings with regard to the tumor suppressor signatureof miR-29b and its regulatory mechanisms. Our review highlights the diverse relationships between miR-29b and its target genes in malignant tumors.

Acknowledgement

Supported by : Guangdong Natural Science Foundation

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