Upregulaton of Bradykinin Receptor Mediated by Nucleoside Diphosphate Kinase and Flagellin from Pseudomonas aeruginosa

Bradykinin Receptor의 발현에 미치는 녹농균유래 Nucleoside Diphosphate Kinase 및 Flagellin의 효과

  • Kim, Yong-Jae (Department of Biotechnology and Bioinformatics, Korea University) ;
  • Shin, Hee-Sung (Department of Biotechnology and Bioinformatics, Korea University) ;
  • Jin, Shouguang (Department of Molecular Genetics and Microbiology, University of Florida) ;
  • Ha, Un-Hwan (Department of Biotechnology and Bioinformatics, Korea University)
  • 김용재 (고려대학교 생명정보공학과) ;
  • 신희성 (고려대학교 생명정보공학과) ;
  • ;
  • 하운환 (고려대학교 생명정보공학과)
  • Received : 2014.09.05
  • Accepted : 2014.10.08
  • Published : 2014.12.31


Immune defense responses against Pseudomonas aeruginosa infection play an important role in maintaining homeostasis in the human body. Previously, we reported that expression of the bradykinin receptor (BR) is induced in response to P. aeruginosa infection. However, the factors responsible for the induction was uncertain. Here, we found that the type III secretion system (T3SS) is responsible for the induction of BR expression, and nucleoside diphosphate kinase (Ndk), as a novel T3SS effector, mediates the upregulation. The Ndk-mediated expression of BR was not induced by fliC mutant treatment, indicating the involvement of flagellin, one of the well-known pathogen-associated molecular patterns (PAMPs). Taken together, this study demonstrated that Ndk cooperates with flagella in the development of defense responses against P. aeruginosa infection.


Pseudomonas aeruginosa;bradykinin receptor;flagellin;nucleoside diphosphate kinase


Supported by : 한국연구재단


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