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Differential Diagnosis and Management of a Pituitary Mass with Renal Cell Carcinoma

  • Hwang, Joo Min (Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital) ;
  • Kim, Yong Hwy (Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital) ;
  • Kim, Tae Min (Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital) ;
  • Park, Sung Hye (Department of Pathology, Seoul National University College of Medicine, Seoul National University Hospital)
  • Received : 2013.01.31
  • Accepted : 2013.08.05
  • Published : 2013.08.28

Abstract

The small pituitary mass was incidentally found in 40-years-old women with renal cell carcinoma. The endocrinological and ophthalmological evaluation revealed no deficit and the short-term follow-up was recommended. In 6 months later, the visual disturbance was reported and the size of mass was increased. The tumor was removed totally via the trans-sphenoid approach. The post-operative endocrinological insufficiency was not noticed. During one year of follow-up period, there was no evidence of recurrence without adjuvant radiotherapy. The clinical features of pituitary metastasis from renal cell carcinoma were similar to those of pituitary adenoma. The possibility of pituitary metastasis should be kept in mind in patients with sellar mass and renal cell carcinoma.

References

  1. Gopan T, Toms SA, Prayson RA, Suh JH, Hamrahian AH, Weil RJ : Symptomatic pituitary metastases from renal cell carcinoma. Pituitary 10 : 251-259, 2007 https://doi.org/10.1007/s11102-007-0047-5
  2. Grossman R, Maimon S, Levite R, Ram Z : Multimodal treatment of hemorrhagic pituitary metastasis as first manifestation of renal cell carcinoma. World Neurosurg 79 : 798.E1-E5, 2013
  3. Hyun SH, Choi JY, Lee KH, Choe YS, Kim BT : Incidental focal 18F-FDG uptake in the pituitary gland : clinical significance and differential diagnostic criteria. J Nucl Med 52 : 547-550, 2011 https://doi.org/10.2967/jnumed.110.083733
  4. Kim YH, Lee BJ, Lee KJ, Cho JH : A case of pituitary metastasis from breast cancer that presented as left visual disturbance. J Korean Neurosurg Soc 51 : 94-97, 2012 https://doi.org/10.3340/jkns.2012.51.2.94
  5. Komninos J, Vlassopoulou V, Protopapa D, Korfias S, Kontogeorgos G, Sakas DE, et al. : Tumors metastatic to the pituitary gland : case report and literature review. J Clin Endocrinol Metab 89 : 574-580, 2004 https://doi.org/10.1210/jc.2003-030395
  6. Kramer CK, Ferreira N, Silveiro SP, Gross JL, Dora JM, Azevedo MJ : Pituitary gland metastasis from renal cell carcinoma presented as a non-functioning macroadenoma. Arq Bras Endocrinol Metabol 54 : 498-501, 2010 https://doi.org/10.1590/S0004-27302010000500011
  7. Max MB, Deck MD, Rottenberg DA : Pituitary metastasis : incidence in cancer patients and clinical differentiation from pituitary adenoma. Neurology 31 : 998-1002, 1981 https://doi.org/10.1212/WNL.31.8.998
  8. Sioutos P, Yen V, Arbit E : Pituitary gland metastases. Ann Surg Oncol 3 : 94-99, 1996 https://doi.org/10.1007/BF02409058
  9. Teears RJ, Silverman EM : Clinicopathologic review of 88 cases of carcinoma metastatic to the putuitary gland. Cancer 36 : 216-220, 1975 https://doi.org/10.1002/1097-0142(197507)36:1<216::AID-CNCR2820360123>3.0.CO;2-E