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Screening of Traditional Medicines for Antioxidative and Anti-proliferative Effects on Rat Mesangial Cells

한약재 추출물의 항산화 및 사구체혈관간세포 증식 억제활성 탐색

  • Sohn, Eun-Hwa (Department of Herbal Medicine Resources, Kangwon National University) ;
  • Jang, Seon-A (Department of Life Science, Gachon University) ;
  • Woo, Han Goo (Department of Life Science, Gachon University) ;
  • Koo, Hyun Jung (Department of Life Science, Gachon University) ;
  • Han, Hyo-Sang (Department of Health Administration, Joongbu University) ;
  • Kang, Se Chan (Department of Life Science, Gachon University)
  • Received : 2013.08.14
  • Accepted : 2013.10.10
  • Published : 2013.10.31

Abstract

In the present study, anti-oxidative and the RMC proliferation inhibitory propeties of 80% ethanol extracts from 63 kinds of traditional medicines were investigated. Inhibitory effects of RMC proliferation were showed that Dalbergia odorifera T. Chen., Melia azedarach Linn$\acute{e}$ and Hydnocarpus anthelmintica Pierre. Among them Hydnocarpus anthelmintica Pierre had the highest anti-oxidative activity ($ORAC_{PE\;value}=1.6$, DPPH = 81.1), but Dalbergia odorifera T. Chen. and Melia azedarach Linn$\acute{e}$ had no effects. These results suggest that the Hydnocarpus anthelmintica Pierre could prevent or protect from kidney disease as antioxidant and anti-proliferative agent for RMC.

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