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Schistosomiasis Combined with Colorectal Carcinoma Diagnosed Based on Endoscopic Findings and Clinicopathological Characteristics: A Report on 32 Cases

  • Liu, Wei (Digestive Endoscopy Center, Department of Gastroenterology, West China Hospital, Sichuan University) ;
  • Zeng, Hong-Ze (Digestive Endoscopy Center, Department of Gastroenterology, West China Hospital, Sichuan University) ;
  • Wang, Qi-Ming (Digestive Endoscopy Center, Department of Gastroenterology, West China Hospital, Sichuan University) ;
  • Yi, Hang (Digestive Endoscopy Center, Department of Gastroenterology, West China Hospital, Sichuan University) ;
  • Mou, Yi (Digestive Endoscopy Center, Department of Gastroenterology, West China Hospital, Sichuan University) ;
  • Wu, Chun-Cheng (Digestive Endoscopy Center, Department of Gastroenterology, West China Hospital, Sichuan University) ;
  • Hu, Bing (Digestive Endoscopy Center, Department of Gastroenterology, West China Hospital, Sichuan University) ;
  • Tang, Cheng-Wei (Digestive Endoscopy Center, Department of Gastroenterology, West China Hospital, Sichuan University)
  • Published : 2013.08.30

Abstract

Aims and Background: To improve understanding of the relationship between schistosome-related enteropathy and colorectal carcinoma with particular focus on endoscopic findings and clinicopathological characteristics of colonic schistosomiasis. Materials and Methods: All cases of intestinal schistosomiasis diagnosed at West China Hospital, Chengdu, China, between October 2006 and October 2012 were included in this study. A total of 179 cases of colonic schistosomiasis diagnosed through colonoscopy and pathological examinations were collected for analysis and the demographics, symptoms, endoscopic findings and clinicopathological characteristics were retrospectively evaluated. Results: Of the 179 colonic schistosomiasis patients, 32 combined with colorectal cancer (CRC) were found, between the ages of 44 and 85 years (24 males, 75%). These 32 lesions were classified as 12 endophytic/ulcerative (37.5%), 10 exophytic/fungating (31.2%), 4 annular (12.5%), 3 giant polypus (9.4%), and 3 IIc (superficial depressed type) (9.4%). The segments of rectum and sigmoid colon were involved in 19 patients (59.4%) and 6 patients (18.8%), respectively. The histopathologic types were classified as follows: 30 welldifferentiated adenocarcinomas, one mucinous adenocarcinoma and one poorly differentiated adenocarcinoma. The pathological findings suggest colorectal malignancy with deposited schistosome ova. Conclusions: Chronic schistosomal infestation has a probable etiological role in promoting genesis of colorectal neoplasms.

Keywords

Colonoscopy;pathological examination;colorectal carcinoma;schistosomiasis

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