- Volume 14 Issue 8
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Diagnostic Value of Protein Ki67 (MIB-1) in Atypical Pap Smears of Postmenopausal Women
- Fakhrjou, Ashraf (Department of Pathology, Tabriz University of Medical Sciences) ;
- Dastranj-Tabrizi, Ali (Department of Pathology, Tabriz University of Medical Sciences) ;
- Ghojazadeh, Morteza (Women's Reproductive Health Research Center) ;
- Ghorashi, Sona (Young Researchers Club, Islamic Azad University) ;
- Velayati, Atefeh (Department of Midwifery, Tabriz Branch, Islamic Azad University) ;
- Piri, Reza (Students' Research Committee, Tabriz University of Medical Sciences) ;
- Vahedi, Amir (Department of Pathology, Tabriz University of Medical Sciences) ;
- Sayyah-Melli, Manizhe (Women's Reproductive Health Research Center) ;
- Smaeili, Heydar-Ali (Department of Pathology, Tabriz University of Medical Sciences) ;
- Bonakdari, Amir (Department of Pathology, Tabriz University of Medical Sciences) ;
- Halimi, Monireh (Department of Pathology, Tabriz University of Medical Sciences) ;
- Naghavi-Behzad, Mohammad (Medical Philosophy and History Research Center, Tabriz University of Medical Sciences)
- Published : 2013.08.30
Background: Atrophic epithelium of cervix sampled from postmenopausal women may mimic high-grade cervical intraepithelial neoplasia in Papanicolaou-stained (Pap) smears. Ki-67 (MIB-1) protein presents on proliferating cells, and percentage of cells with positive nuclei provides a reliable tool for rapid evaluation of the growth fraction. The aim of this study was to determine the diagnostic value of protein Ki67 staining in atypical pap smears of postmenopausal women. Methods: In a case-control setting, pap smears of 75 women with an atypical pap smear (case group) and 75 with normal pap smears (controls) were obtained before and after estrogen treatment. Afterward, samples were exposed to the monoclonal antibody Ki-67 (MIB-1) and the immunohistochemically demonstrated Ki-67+ cells were compared. Results: Mean ages of cases and controls were
Vaginal smears;Ki-67 antigen;postmenopause;negative predictive potential
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