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GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling

  • Zhu, Yong-Bin (Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Xu, Lin (Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Chen, Ming (Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Ma, Hai-Na (Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Lou, Fang (Department of Oncology, Run Run Shaw Hospital, Zhejiang University School of Medicine)
  • Published : 2013.08.30

Abstract

The key signaling networks regulating cancer cell proliferation remain to be defined. The leucine-rich repeat containing G-protein coupled receptor 48 (GPR48) plays an important role in multiple organ development. In the present study, we investigated whether GPR48 functions in cancer cells using MCF-7, HepG2, NCI-N87 and PC-3 cells. We found that GPR48 overexpression promotes while its knockdown using small interfering RNA oligos inhibits cell proliferation. In addition, Wnt/${\beta}$-catenin signaling was activated in cells overexpressing GPR48. Therefore, our results indicated that GPR48 activates Wnt/${\beta}$-catenin signaling to regulate cancer cell proliferation.

Keywords

GPR48;Wnt/${\beta}$-catenin;cancer cell;cell proliferation

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