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Variation of Blood T Lymphocyte Subgroups in Patients with Non- small Cell Lung Cancer

  • Wang, Wen-Jing (Department of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University) ;
  • Tao, Zhen (Department of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University) ;
  • Gu, Wei (Department of Respiration, Nanjing First Hospital, Nanjing Medical University) ;
  • Sun, Li-Hua (Department of Respiration, Nanjing First Hospital, Nanjing Medical University)
  • Published : 2013.08.30

Abstract

Objectives: To study variation in T lymphocyte subgoups and its clinical significance in non-small cell lung cancer (NSCLC). Methods: Levels of CD3+, CD4+, CD8+, CD4+/CD8+, NK and Treg cells in peripheral blood of NSCLC cases and healthy adults were determined by flow cytometry. Results: CD3+, CD4+ and CD4+/CD8+ ratio and NK cells in NSCLCs were decreased significantly in comparison with the control group (P < 0.01), and decreased with increase in the clinical stage of NSCLC, while CD8+ cells demonstrated no significant change (P > 0.05). Treg cells were significantly more frequent than in the control group (P < 0.01), and increased with the clinical stage of NSCLC. Conclusion: The cellular immune function of the NSCLC patients is lowered. It is important to detect change of T lymphocyte subgroups by flow cytometry for the diagnosis, treatment and prognostic assessment of NSCLC patients.

Keywords

Non-small cell lung cancer;lymphocyte subset;flow cytometry;cellular immune

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