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HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

  • Xiao, Xue (Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University) ;
  • Liu, Li (Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University) ;
  • Li, Wei-Jie (Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University) ;
  • Liu, Juan (Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University) ;
  • Chen, Dun-Jin (Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University)
  • Published : 2013.07.30

Abstract

Cervical cancer is the second most common cancer in women. HLA class I and II alleles polymorphisms have been shown to be associated with cervical cancer risk, but results have varied among different populations. In this study, the HLA-A, -B, and -DRB1 alleles among 100 southern Chinese women with cervical squamous cell carcinoma (SCC) were compared to 254 controls. Our results showed that $B^*51$:01:02 allele frequency was significantly higher in patients with SCC than in healthy controls ($P=3.17{\times}10^{-5}$, $P_c$=0.005, OR=26.7). Statistical analysis also revealed a significantly decreased frequency of $B^*51$:01:02 ($P=7.01{\times}10^{-4}$, $P_c$=0.03, OR=0.12) in patients with SCC when compared with healthy controls. These results indicate that HLA-$B^*51$:01:02 may confer susceptibility to SCC and HLA-$B^*51$:01:02 may contribute to resistance to the development of SCC in Chinese women. None of the HLA-A-B or HLA-A-B-DRB1 haplotypes were significantly different in cases and controls after multiple testing corrections, indicating the individual allele associations to be independent of the identified haplotypes. These results support the hypothesis that some HLA-B alleles could be involved with susceptibility for developing SCC.

Keywords

Cervical squamous cell carcinoma;human leukocyte antigens;polymorphism;susceptibility

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