- Volume 14 Issue 7
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Season of Diagnosis and Survival of Advanced Lung Cancer Cases - Any Correlation?
- Oguz, Arzu (Medical Oncology Department, Faculty of Medicine, Baskent University) ;
- Unal, Dilek (Kayseri Education and Research Hospital, Radiation Oncology Clinic) ;
- Kurtul, Neslihan (Erciyes University, Radiation Oncology Clinic) ;
- Aykas, Fatma (Kayseri Education and Research Hospital, Internal Medicine Clinic) ;
- Mutlu, Hasan (Acibadem Hospital, Medical Oncology Clinic) ;
- Karagoz, Hatice (Kayseri Education and Research Hospital, Internal Medicine Clinic) ;
- Cetinkaya, Ali (Kayseri Education and Research Hospital, Internal Medicine Clinic)
- 발행 : 2013.07.30
Introduction: The influence of season at diagnosis on cancer survival has been an intriguing issue for many years. Most studies have shown a possible correlation in between the seasonality and some cancer type survival. With short expected survival, lung cancer is an arena that still is in need of new prognostic factors and models. We aimed to investigate the effect of season of diagnosis on 3 months, 1 and 2 years survival rates and overall survival of non small cell lung cancer patients. Materials and Methods: The files of non small cell lung cancer patients that were stages IIIB and IV at diagnosis were reviewed retrospectively. According to diagnosis date, the patients were grouped into 4 season groups, autumn, winter, spring and summer. Results: A total of 279 advanced non small cell lung cancer patients' files were reviewed. Median overall survival was 15 months in the entire population. Overall 3 months, 1 and 2 years survival rates were 91.0%, 58.2% and 31.2% respectively. The season of diagnosis was significantly correlated with 3 months survival rates, being diagnosed in spring being associated with better survival. Also the season was significantly correlated with T stage of the disease. For 1 and 2 years survival rates and overall survival, the season of diagnosis was not significantly correlated. There was no correlation detected between season and overall survivals according to histological subtypes of non small cell lung cancer. Conclusion: As a new finding in advanced non small cell lung cancer patients, it can be concluded that being diagnosed in spring can be a favorable prognostic factor for short term survival.
Lung cancer;non small cell;season;survival
- Apperly F (1941). The relation of solar radiation to cancer mortality in North America. Cancer Res, 1, 191-5.
- Brundage MD, Davies D, Mackillop WJ (2002). Prognostic factors in non small cell lung cancer: a decade of progress. Chest, 122, 1037-57. https://doi.org/10.1378/chest.122.3.1037
- Eberhard DA, Johnson BE, Amler LC, et al (2005). Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with nonsmall cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol, 23, 5900-9. https://doi.org/10.1200/JCO.2005.02.857
- Eccles R (2002). An explanation for the seasonality of acute upper respiratory tract viral infections. Acta Otolaryngol, 122, 183-91. https://doi.org/10.1080/00016480252814207
- Efficace F, Bottomley A, Smit EF, et al (2006). Is a patient's self-reported health related quality of life a prognostic factor for survival in non-small cell lung cancer patients? A multivariate analysis of prognostic factors of EORTC study 08975. Ann Oncol, 17, 1698-704. https://doi.org/10.1093/annonc/mdl183
- Finkelstein DM, Ettinger DS, Ruckdeschel JC (1986). Long term survivors in metastatic non small cell lung cancer: an Eastern Cooperative Oncology Group Study. J Clin Oncol, 4, 702-9.
- Garland CF, Garland FC (1980). Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol, 9, 227-31. https://doi.org/10.1093/ije/9.3.227
- Garland CF, Comstock GW, Garland FC, et al (1989). Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet, 2, 1176-8.
- Hwang IG, Ahn MJ, Park BB, et al (2008). ERCC1 expression as a prognostic marker in N2 (+) non small cell lung cancer patients treated with platinum based neoadjuvant concurrent chemoradiotherapy. Cancer, 113, 1379-86. https://doi.org/10.1002/cncr.23693
- Kaiser U, Schilli M, Wegmann B, et al (1996). Expression of vitamin D receptor in lung cancer. J Cancer Res Clin Oncol, 122, 356-9. https://doi.org/10.1007/BF01220803
- LaPar DJ, Nagji AS, Bhamidipati CM, et al (2011). Seasonal variation influences outcomes following lung cancer resections. Eur J Cardiothorac Surg, 40, 83-90. https://doi.org/10.1016/j.ejcts.2010.11.023
- Lim HS, Roychoudhuri R, Peto J, et al (2006). Cancer survival is dependent on season of diagnosis and sunlight exposure. Int J Cancer, 119, 1530-6. https://doi.org/10.1002/ijc.22052
- Moscaux C, Iannino N, Martin B, et al (2005). The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis. Bri J Cancer, 92, 131-9. https://doi.org/10.1038/sj.bjc.6602258
- Mutlu H, Akca Z, Cihan YB, et al (2013). Is season a prognostic factor in breast cancer? Asian Pac J Cancer Prev, 14, 743-6. https://doi.org/10.7314/APJCP.2013.14.2.743
- Ordonez-Moran P, Larriba MJ, Pendas-Franco N, et al (2005). Vitamin D and cancer: an update of in vitro and in vivo data. Front Biosci, 10, 2723-49. https://doi.org/10.2741/1731
- Porojnicu AC, Dahlback A, Moan J (2008). Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude. Adv Exp Med Biol, 624, 43-54. https://doi.org/10.1007/978-0-387-77574-6_4
- Reynolds C, Obasaju C, Schell MJ, et al (2009). Randomised phase III trial of gemcitabine based chemotherapy with in situ RRM1 and ERCC1 protein levels for response prediction in non small cell lung cancer. J Clin Oncol, 27, 5808-15. https://doi.org/10.1200/JCO.2009.21.9766
- Robsahm TE, Tretli S, Dahlback A, Moan J (2004). Vitamin D3 from sunlight may improve the prognosis of breast, colon and prostate cancer (Norway). Cancer Causes Control, 15, 149-58. https://doi.org/10.1023/B:CACO.0000019494.34403.09
- Roychoudhuri R, Robinson D, Coupland V, Holmberg L, Moller H (2009). Season of cancer diagnosis exerts distinct effects upon short and long-term survival. Int J Cancer, 124, 2436-41. https://doi.org/10.1002/ijc.24213
- Sequist LV, Joshi VA, Janne PA, et al (2007). Response to treatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing. Oncologist, 12, 90-8. https://doi.org/10.1634/theoncologist.12-1-90
- Shaw AT, Yeap BY, Mino-Kenudson M, et al (2009). Clinical features and outcome of patients with non-small cell lung cancer who harbor EML4-ALK. J Clin Oncol, 27, 4247-53. https://doi.org/10.1200/JCO.2009.22.6993
- Siegel R, Naishadham D, Jemal A (2012). Cancer statistics, 2012. CA Cancer J Clin, 62,10-29. https://doi.org/10.3322/caac.20138
- Simon GR, Sharma S, Cantor A, Smith P, Bepler G (2005). ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer. Chest, 127, 978-83. https://doi.org/10.1378/chest.127.3.978
- Tsao MS, Sakurada A, Ding K, et al (2011). Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer. J Thorac Oncol, 6, 139-47. https://doi.org/10.1097/JTO.0b013e3181fd83a4
- Yokomura K, Suda T, Sasaki S, et al (2003). Increased expression of the 25-hydroxyvitaminD(3)-1alpha-hydroxylase gene in alveolar macrophages of patients with lung cancer. J Clin Endocrinol Metab, 88, 5704-9. https://doi.org/10.1210/jc.2003-030537
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