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B-cell Lymphoma 2 rs17757541 C>G Polymorphism was Associated with an Increased Risk of Gastric Cardiac Adenocarcinoma in a Chinese Population

  • Li, Qiong (Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology) ;
  • Yin, Jun (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Wang, Xu (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Wang, Li-Ming (Cancer Institute, Department of Chemotherapy, People's Hospital Affiliated to Jiangsu University) ;
  • Shi, Yi-Jun (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Zheng, Liang (Department of Cardiothoracic Surgery, The First People's Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University) ;
  • Tang, Wei-Feng (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Ding, Guo-Wen (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Liu, Chao (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Liu, Rui-Ping (Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital) ;
  • Gu, Hai-Yong (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Sun, Jia-Ming (Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology) ;
  • Chen, Suo-Cheng (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
  • Published : 2013.07.30

Abstract

Aim: Apoptosis has been considered as a fundamental component in cancer pathogenesis, and related genetic factors might play an important role in gastric cardiac adenocarcinoma (GCA) genesis. Methods: We conducted a hospital based case.control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): BCL2 rs17757541 C>G, BCL2 rs12454712 T>C, FAS rs2234767 G>A, FASL/FASLG rs763110 C>T, ERBB2 rs1136201 A>G and VEGFR2/KDR rs11941492 C>T on the development of GCA. A total of 243 GCA cases and 476 controls were recruited for the study and genotypes were determined using a custom-by-design 48-Plex SNPscan$^{TM}$ Kit. Results: The BCL2 rs17757541 C>G polymorphism was associated with increased risk of GCA. However, there was no significant associations with the other five SNPs. Stratified analyses indicated a significantly increased risk of GCA associated with the BCL2 rs17757541 C>G polymorphism among males, older patients and those with a history of smoking or drinking. Conclusion: These findings indicated that the functional polymorphism BCL2 rs17757541 C>G might contribute to GCA susceptibility. However, our results were limited by small sample size. Future larger studies are required to confirm our current findings.

Keywords

BCL2;polymorphisms;gastric cardiac adenocarcinoma;molecular epidemiology

References

  1. Alenzi FQ, Lotfy M, Wyse R (2010). Swords of cell death: caspase activation and regulation. Asian Pac J Cancer Prev, 11, 271-80.
  2. Chen K, Hu Z, Wang LE, et al (2007). Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck. Carcinogenesis, 28, 2008-12. https://doi.org/10.1093/carcin/bgm172
  3. Cheng J, Zhang H, Zhuang C, et al (2012). Peptidylarginine deiminase type 4 and methyl-CpG binding domain 4 polymorphisms in Chinese patients with rheumatoid arthritis. J Rheumatol, 39, 1159-65. https://doi.org/10.3899/jrheum.120007
  4. Cory S, Adams JM (2002). The BCL2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer, 2, 647-56. https://doi.org/10.1038/nrc883
  5. Elmore S (2007). Apoptosis: a review of programmed cell death. Toxicol Pathol, 35, 495-516. https://doi.org/10.1080/01926230701320337
  6. Enjuanes A, Benavente Y, Bosch F, et al (2008). Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. Cancer Res, 68, 10178-86. https://doi.org/10.1158/0008-5472.CAN-08-2221
  7. Eun YG, Hong IK, Kim SK, et al (2011). A Polymorphism (rs1801018, Thr7Thr) of BCL2 is Associated with Papillary Thyroid Cancer in Korean Population. Clin Exp Otorhinolaryngol, 4, 149-54. https://doi.org/10.3342/ceo.2011.4.3.149
  8. Giatromanolaki A, Koukourakis MI, Sivridis E, et al (2007). Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer. Eur J Clin Invest, 37, 878-86. https://doi.org/10.1111/j.1365-2362.2007.01866.x
  9. Holler N, Tardivel A, Kovacsovics-Bankowski M, et al (2003). Two adjacent trimeric FAS ligands are required for FAS signaling and formation of a death-inducing signaling complex. Mol Cell Biol, 23, 1428-40. https://doi.org/10.1128/MCB.23.4.1428-1440.2003
  10. Jain M, Kumar S, Lal P, et al (2007). Role of BCL2 (ala43thr), CCND1 (G870A). and FAS (A-670G). polymorphisms in modulating the risk of developing esophageal cancer. Cancer Detect Prev, 31, 225-32. https://doi.org/10.1016/j.cdp.2007.04.005
  11. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, et al (2000). Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest, 106, 1311-9. https://doi.org/10.1172/JCI10259
  12. Kroemer G (1997). The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med, 3, 614-20. https://doi.org/10.1038/nm0697-614
  13. Lowe SW, Lin AW (2000). Apoptosis in cancer. Carcinogenesis, 21, 485-95. https://doi.org/10.1093/carcin/21.3.485
  14. Nagata S (1997). Apoptosis by death factor. Cell, 88, 355-65. https://doi.org/10.1016/S0092-8674(00)81874-7
  15. Nagata S (1999). FAS ligand-induced apoptosis. Annu Rev Genet, 33, 29-55. https://doi.org/10.1146/annurev.genet.33.1.29
  16. Seto M, Jaeger U, Hockett RD, et al (1988). Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. Embo J, 7, 123-31.
  17. Sun J, Li Q, Gu H, et al (2013). Interleukin 10 rs1800872 T>G Polymorphism was associated with an increased risk of esophageal cancer in a Chinese population. Asian Pacific J Cancer Prev, 14, 6213-7.
  18. Wei J, Zheng L, Liu S, et al (2013). MiR-196a2 rs11614913 T>C polymorphism and risk of esophageal cancer in a Chinese population. Hum Immunol, doi:pii: S0198-8859(13)00169-9.10.1016/j.humimm.2013.06.012 [Epub ahead of print]. https://doi.org/10.1016/j.humimm.2013.06.012
  19. Wu IC, Zhao Y, Zhai R, et al (2011). Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Neoplasia, 13, 386-92.
  20. Yarden Y, Sliwkowski MX (2001). Untangling the ErbB signalling network. Nat Rev Mol Cell Biol, 2, 127-37. https://doi.org/10.1038/35052073
  21. Yin J, Wang L, Shi Y, et al (2013). Interleukin 17A rs4711998 A>G polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Dis Esophagus, DOI: 10.1111/dote.12045. https://doi.org/10.1111/dote.12045
  22. Yu D, Jing T, Liu B, et al (1998). Overexpression of ERBB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Mol Cell, 2, 581-91. https://doi.org/10.1016/S1097-2765(00)80157-4
  23. Zheng L, Yin J, Wang L, et al (2013). Interleukin 1B rs16944 G>A polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Clin Biochem, doi: 10.1016/j.clinbiochem.2013.05.050. [Epub ahead of print]. https://doi.org/10.1016/j.clinbiochem.2013.05.050
  24. Zinkel S, Gross A, Yang E (2006). BCL2 family in DNA damage and cell cycle control. Cell Death Differ, 13, 1351-9. https://doi.org/10.1038/sj.cdd.4401987

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