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B-cell Lymphoma 2 rs17757541 C>G Polymorphism was Associated with an Increased Risk of Gastric Cardiac Adenocarcinoma in a Chinese Population

  • Li, Qiong (Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology) ;
  • Yin, Jun (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Wang, Xu (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Wang, Li-Ming (Cancer Institute, Department of Chemotherapy, People's Hospital Affiliated to Jiangsu University) ;
  • Shi, Yi-Jun (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Zheng, Liang (Department of Cardiothoracic Surgery, The First People's Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University) ;
  • Tang, Wei-Feng (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Ding, Guo-Wen (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Liu, Chao (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Liu, Rui-Ping (Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital) ;
  • Gu, Hai-Yong (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Sun, Jia-Ming (Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology) ;
  • Chen, Suo-Cheng (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
  • Published : 2013.07.30

Abstract

Aim: Apoptosis has been considered as a fundamental component in cancer pathogenesis, and related genetic factors might play an important role in gastric cardiac adenocarcinoma (GCA) genesis. Methods: We conducted a hospital based case.control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): BCL2 rs17757541 C>G, BCL2 rs12454712 T>C, FAS rs2234767 G>A, FASL/FASLG rs763110 C>T, ERBB2 rs1136201 A>G and VEGFR2/KDR rs11941492 C>T on the development of GCA. A total of 243 GCA cases and 476 controls were recruited for the study and genotypes were determined using a custom-by-design 48-Plex SNPscan$^{TM}$ Kit. Results: The BCL2 rs17757541 C>G polymorphism was associated with increased risk of GCA. However, there was no significant associations with the other five SNPs. Stratified analyses indicated a significantly increased risk of GCA associated with the BCL2 rs17757541 C>G polymorphism among males, older patients and those with a history of smoking or drinking. Conclusion: These findings indicated that the functional polymorphism BCL2 rs17757541 C>G might contribute to GCA susceptibility. However, our results were limited by small sample size. Future larger studies are required to confirm our current findings.

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