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Clinical Significance and Prognostic Value of Pentraxin-3 as Serologic Biomarker for Lung Cancer

  • Zhang, Dai (Department of Clinical Laboratory, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine) ;
  • Ren, Wei-Hong (Department of Clinical Laboratory, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine) ;
  • Gao, Yun (Center of Clinical Laboratory, Henan Province Tumour Hospital) ;
  • Wang, Nian-Yue (Department of Clinical Laboratory, the Second Affiliated Hospital of Southeast University) ;
  • Wu, Wen-Jun (Department of Clinical Laboratory, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine)
  • Published : 2013.07.30

Abstract

Purposes: Lung cancer is prevalent worldwide and improvements in timely and effective diagnosis are need. Pentraxin-3 as a novel serum marker for lung cancer (LC) has not been validated in large cohort studies. The aim of the study was to assess its clinical value in diagnosis and prognosis. Methods: We analyzed serum PTX-3 levels in a total of 1,605 patients with LC, benign lung diseases and healthy controls, as well as 493 non-lung cancer patients including 12 different types of cancers. Preoperative and postoperative data were further assessed in patients undergoing LC resection. The diagnostic performance of PTX-3 for LC and early-stage LC was assessed using receiver operating characteristics (ROC) by comparing with serum carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA 21-1). Results: Levels of PTX-3 in serum were significantly higher in patients with LC than all controls. ROC curves showed the optimum diagnostic cutoff was 8.03ng/mL (AUC 0.823, [95%CI 0.789-0.856], sensitivity 72.8%, and specificity 77.3% in the test cohort; 0.802, [95%CI 0.762-0.843], sensitivity 69.7%, and specificity 76.4% in the validate cohort). Similar diagnostic performance of PTX-3 was observed for early-stage LC. PTX-3 decreased following surgical resection of LC and increased with tumor recurrence. Significantly elevated PTX-3 levels were also seen in patients with non-lung cancers. Conclusions: The present data revealed that PTX-3 was significantly increased in both tissue and serum samples in LC patients. PTX-3 is a valuable biomarker for LC and improved identification of patients with LC and early-stage LC from those with non-malignant lung diseases.

Keywords

Lung neoplasm;serum marker;pentraxin-3;diagnosis

Acknowledgement

Supported by : Henan Basic and Frontier Technology Research

References

  1. Alessandro R, Fontana S, Kohn E, De Leo G (2005). Proteomic strategies and their application in cancer research. Tumori, 9, 447-55.
  2. Allin KH, Bojesen SE, Nordestgaard BG (2009). Baseline C-Reactive Protein Is Associated With Incident Cancer and Survival in Patients With Cancer. J Clin Oncol, 27, 2217-24. https://doi.org/10.1200/JCO.2008.19.8440
  3. Balkwill F, Mantovani A (2001). Inflammation and cancer: back to Virchow? Lancet, 357, 539-45 https://doi.org/10.1016/S0140-6736(00)04046-0
  4. Banks R, Selby P (2003). Clinical proteomics-insights into pathologies and benefits for patients. Lancet, 362, 415-6. https://doi.org/10.1016/S0140-6736(03)14096-2
  5. Deban L, Jaillon S, Garlanda C, et al (2010). Pentraxins in innate immunity: lessons from PTX3. Cell Tissue Res, 343, 237-49.
  6. Diamandis EP, Goodglick L, Planque C, et al (2011). Pentraxin-3 is a novel biomarker of lung Carcinoma. Clin Cancer Res, 17, 2395-99. https://doi.org/10.1158/1078-0432.CCR-10-3024
  7. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  8. Garlanda C, Bottazzi B, Bastone A, et al (2005). Pentraxins at the crossroads between innate mmunity,inflammation, matrix deposition, and female fertility. Annu Rev Immunol, 23, 337-66. https://doi.org/10.1146/annurev.immunol.23.021704.115756
  9. Groome PA, Bolejack V, Cruwley JJ, et a1 (2007).The IASLC Lung Cancer Staging Project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol, 2, 694-705. https://doi.org/10.1097/JTO.0b013e31812d05d5
  10. Hassanein M, Callison JC, Callaway-Lane C, et al (2012). The state of molecular biomarkers for the early detection of lung cancer. Cancer Prev Res, 5, 992-1006. https://doi.org/10.1158/1940-6207.CAPR-11-0441
  11. IARC Working Group (1997). IARC handbook of cancer prevention, volume 1: non-steroidal anti-inflammatory drugs. Lyon (France): IARC-WHO.
  12. Jackson JR, Seed MP, Kircher CH, et al (1997). The codependence of angiogenesis and chronic inflammation. FASEB J, 11, 457-65.
  13. Jaiswal M, LaRusso NF, Burgart LJ, et al (2000). Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res, 60, 184-90.
  14. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  15. Keller A, Leidinger P, Gislefoss R, et a1(201l). STable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis. RNA Biol, 8, 506-16. https://doi.org/10.4161/rna.8.3.14994
  16. Kulasingam V, Diamandis EP (2008). Strategies for discovering novelcancer biomarkers through utilization of emerging technologies. Nat Clin Pract Oncol, 5, 588-99. https://doi.org/10.1038/ncponc1187
  17. Kuper H, Adami HO, Trichopoulos D (2000). Infections as a major prevenTable cause of human cancer. J Intern Med, 248, 171-83. https://doi.org/10.1046/j.1365-2796.2000.00742.x
  18. Coussens LM, Werb Z (2002). Inflammation and cancer. Nature, 19, 860-67
  19. Locatelli M, Ferrero S, Martinelli Boneschi F, et al.The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas(2013). J Neuroimmunol, 260, 99-106
  20. Locker GY, Hamilton S, Harris J, et al (2006). ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol, 24, 5313-27. https://doi.org/10.1200/JCO.2006.08.2644
  21. Martini N,Baills MS, Burt ME, et a1(1995). Incidence of local recurrence and second primaries in resected stage I lung cancer. J Thorac Cardiovasc Surg, 109, 120-9. https://doi.org/10.1016/S0022-5223(95)70427-2
  22. McWilliams A, Lmn B, Sutedja T (2009). Early proximal lung cancer diagnosis and treatment. Eur Respir J, 33, 656-65. https://doi.org/10.1183/09031936.00124608
  23. Okutani D (2006). The role of long pentraxin 3, a new inflammatory mediator in inflammatory responses. Nihon Rinsho Meneki Gakkai Kaishi, 29, 107-13. https://doi.org/10.2177/jsci.29.107
  24. Pepe MS, Etzioni R, Feng Z, et al (2001). Phases of biomarker development for early detection of cancer. J Natl Cancer Inst, 93, 1054-61. https://doi.org/10.1093/jnci/93.14.1054
  25. Planque C, Kulasingam V, Smith CR, et al (2009). Identification of five candidate lung cancer biomarkers by proteomics analysis of conditioned media of four lung cancer cell lines. Mol Cell Proteomics, 8, 2746-58. https://doi.org/10.1074/mcp.M900134-MCP200
  26. Pujol JL, Grenier J, Daures JP, et al (1993). Serum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer. Cancer Res, 53, 61-6.
  27. Rabman SM, Gonzalez AL, Li M, et a1 (2011). Lung cancer diagnosis from proteomic analysis of preinvasive lesions. Cancer Res, 71, 3009-17. https://doi.org/10.1158/0008-5472.CAN-10-2510
  28. Ravenna L, Sale P, Di Vito M, et al (2009). Up-regulation of the inflammatory-reparative phenotype in human prostate carcinoma. The Prostate, 69, 1245-55. https://doi.org/10.1002/pros.20966
  29. Reed MF, Molloy M, Dalton EL, et al (2004). Survival after resection for lung cancer is the outcome that matters. Am J Surg, 188, 598-602. https://doi.org/10.1016/j.amjsurg.2004.07.037
  30. Sehramm M, Wrobel C, Born I, et al (2011). Equivocal cytology in lung cancer diagnosis: improvement of diagnostic accuracy using adjuvant multicolor FISH, DNA-image cytometry, and quantitative promoter hypermethylation analysis. Cancer Cytopathol, 119, 177-92. https://doi.org/10.1002/cncy.20142
  31. Shinkai T, Saijo N, Tominaga K, et al (1986). Serial plasma carcinoembryonic antigen measurement for monitoring patients with advanced lung cancer during chemotherapy. Cancer, 57, 1318-23. https://doi.org/10.1002/1097-0142(19860401)57:7<1318::AID-CNCR2820570711>3.0.CO;2-2
  32. Spiro SG, Gould MK, Colice GL,et al (2007). Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest, 132, S149-60. https://doi.org/10.1378/chest.07-1358
  33. Wagner PD, Verma M, Srivastava S (2004). Challenges for biomarkers in cancer detection. Ann N Y Acad Sci, 1022, 9-16. https://doi.org/10.1196/annals.1318.003
  34. Willeke F, Assad A, Findeisen P, et al (2005). Overexpression of a member of the pentraxins family (PTX3) in human soft tissue liposarcoma. Eur J Cancer, 42, 2639-46.

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