Epidemiology of Esophageal Cancer in Ardabil Province During 2003-2011

  • Amani, Firouz (Department of Community Medicine, Ardabil University of Medical Science) ;
  • Ahari, Saeid Sadeghieh (Department of Community Medicine, Ardabil University of Medical Science) ;
  • Akhghari, Lyla (General practitioner, Ardabil University of Medical Science)
  • Published : 2013.07.30


Background: The aim of this research was to perform an epidemiologic survey of esophageal cancer in Ardabil province. Materials and Methods: In this cross-sectional descriptive study, 661 patients diagnosed with EC were studied from March 2002 to May 2011 e. The necessary data were collected with a checklist from the documents in Ardabil Cancer Registry (ACR) and analyzed by statistical methods with SPSS.18 software. Results: Of the total new cases of EC registered in ARC during study period, 430 (65.1%) of patients were male with the male to female standard ratio was 1.18, with a statistically significant gender bias. The most common morphology of EC was squamous cell carcinoma (SCC, 68.8%) followed by adenocarcinoma (28.5%). It was observed that in most of patients, EC lesions were in the middle third of esophagus. In addition, most patients were rural and about 40% had smoking habits. The age-standardized incidence rate of cancers was 48.4 per 100,000 among females and males. The annual incidence rates in males and females was 7.1 and 6.7 per 100,000; respectively. Conclusions: Results showed that the prevalence and annual incidence rate of cancer in Ardabil province is lower than other areas of the country with a male predominance and a relatively high proprortion of adenocarcinomas.


  1. Anvari K, Aledavood A, Sabouri G (2011). Esophageal Cancer in Northeast of Iran. Iran J Cancer Prev, 4, 125-9.
  2. Babaeei M, Jafarzaadeh H, Sajadi S, Samadi F, Yazdanbod A (2009). Cancer Incidence and mortality in ardabil: report of an ongoing population-based cancer registry in Iran, 2004-2006. Iran J Public Health, 38, 35-45.
  3. Boyle P, Levin B (2008). World Cancer Report, IARC.
  4. Corrao G, Bagnardi V, Zambon A, La Vecchia C (2004). A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med, 38, 613-9.
  5. Ferlay J, Shin HR, Bray F, et al (2008). GLOBOCAN v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet] Lyon, France: International Agency for Research on Cancer, 2010. Available from: Accessed May 2011.
  6. Freedman ND, Abnet CC, Leitzmann MF, et al (2007). A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes. Am J Epidemiol, 165, 1424-33.
  7. Mansour-Ghanaei F, Heidarzadeh A, Naghipour MR (2012). A 10-year Study of Esophageal Cancer in Guilan Province, Iran: The Guilan Cancer Registry Study (GCRS). Asian Pac J Cancer Prev, 13, 6277-83.
  8. Hajian K (2003). The epidemiologic investigation of patients suffering esophageal Cancer visiting Shahid Rajai radiotherapy center of Babolsar. J Gorgan Univ med sci, 5, 73-9.
  9. Jalali S, Mahami S (2005). The epidemiologic and pathologic investigation of upper digestive tract cancers (esophagus and stomach) in Ardabil clinic specialized in digestive system in 2000-2001. Unpublished doctoral dissertation, Ardabil University of medical science.
  10. Igissinov S, Igissinov N, Moore MA, Kalieva Z, Kozhakhmetov S (2012). Epidemiology of esophageal cancer in Kazakhstan. Asian Pac J Cancer Prev, 13, 833-6.
  11. Mashhadi MA, Nezam K, Bakhshipour AR, Ttorbati TF, Ansarimoghaddam AR (2011). High prevalence of esophageal cancer in South East of Iran. IJHOSCR, 5, 18-21.
  12. Mirineghad SK, Somi MH, Jangjoo AG, et al (2012). Survival rate and prognostic factors of esophageal cancer in East Azerbaijan Province, North-west of Iran. Asian Pac J Cancer Prev, 13, 3451-4.
  13. Pedram A, Mahmodlou R, Enshayi A, Sepehrvand N (2011). Esophageal cancer in northwestern Iran. Indian J Cancer, 48, 165-9.
  14. Pourfarzi F, Barak M, Babaei M, et al (2011). The features of esophageal cancer in ardabil province:report of a population-based cancer registry in Northwest Iran. Govaresh, 16, 55-60.
  15. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008). Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet, 371, 569-78.
  16. Semnani Sh, Basharat S, Abdolahi N, et al (2004). Factors associated with esophageal cancer in the southeast part of the Caspian Sea. J Guilan Univ Med Sci, 13, 24-28.
  17. Wild CP, Hardie LJ (2003). Hardie Reflux, Barrett's oesophagus and adenocarcinoma: burning questions. Nat Rev Cancer, 3, 676-84.
  18. Yomralioglu T, Ebru H (2009). Geo-Relationship between cancer cases and the environment by GIS: a case study of Trabzon in Turkey. Int J Environ Res Public Health, 6, 3190-204.

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