- Volume 14 Issue 7
DOI QR Code
Inflammation Enhanced X-irradiation-Induced Colonic Tumorigenesis in the Min mouse
- Nojiri, Ayumi (Division of Oncological Pathology, Aichi Cancer Center Research Institute) ;
- Toyoda, Takeshi (Division of Oncological Pathology, Aichi Cancer Center Research Institute) ;
- Tanaka, Takuji (The Tohkai Cytopathology Institute, Cancer Research and Prevention) ;
- Yoshida, Toshimichi (Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine) ;
- Tatematsu, Masae (Division of Oncological Pathology, Aichi Cancer Center Research Institute) ;
- Tsukamoto, Tetsuya (Division of Oncological Pathology, Aichi Cancer Center Research Institute)
- Published : 2013.07.30
Inflammation is potential risk factor of various human malignancies. Inflammatory bowel syndromes such as ulcerative colitis are well known as risk factors for colon cancer. Here, we examined enhancing effects of dextran sulfate sodium (DSS)-associated inflammation on X-irradiation induced colonic tumorigenesis in Min and wild-type (WT) mice. Animals were X-irradiated at 1.5 Gy at 5 weeks of age (at 0 experimental week) and 2% DSS in drinking water was administered at 5 or 11 experimental weeks. Mice were sacrificed at 16 weeks and incidence and multiplicity of colonic tumors were assessed. Incidence of colonic tumors in Min mouse was increased from 33.3% to 100% (p<0.05) with X-irradiation alone, whereas no tumors were developed in WT mice. In DSS-treated Min mice, X-irradiation increased the number of colonic tumors. Total number of colonic tumors was increased 1.57 times to
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