MicroRNA-16 Inhibits Bladder Cancer Proliferation by Targeting Cyclin D1

  • Jiang, Qi-Quan (Department of Urology, Affiliated Tongji Hospital, Tongji University) ;
  • Liu, Bin (Shanghai Institute of Materia Medica, Chinese Academy of Sciences) ;
  • Yuan, Tao (Department of Urology, Affiliated Tongji Hospital, Tongji University)
  • Published : 2013.07.30


MicroRNA-16 (miR-16) has been demonstrated to regulate proliferation and apoptosis in many types of cancers, but its biological function in bladder cancer remains unknown. Here, we found expression of miR-16 to be downregulated in bladder cancer in comparison with the adjacent normal tissues. Enforced expression of miR-16 was able to inhibit cell proliferation in TCHu-1 cells, in line with results for miR-16 antisense oligonucleotides (antisense miR-16). At the molecular level, our results further revealed that cyclin D1 expression was negatively regulated by miR-16. Therefore, the data reported here demonstrate that miR-16 is an important regulator in bladder cancer, which will contribute to better understanding of important mis-regulated miRNAs.


MicroRNA-16;Cyclin D1;bladdercancer;cell proliferation


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