Xeroderma Pigmentosum Complementation Group F Polymorphisms Influence Risk of Glioma

  • Cheng, Hong-Bin (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University) ;
  • Xie, Chen (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University) ;
  • Zhang, Ru-You (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University) ;
  • Hu, Shao-Shan (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University) ;
  • Wang, Zhi (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University) ;
  • Yue, Wu (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University)
  • Published : 2013.07.30


We conducted an exploratory investigation of whether variation in six common SNPs of xeroderma pigmentosum complementation group F (XPF) is associated with risk of glioma in a Chinese population. Six single nucleotide polymorphisms (SNPs) were genotyped in 207 glioma cases and 236 cancer-free controls by a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). The rs1800067 G and rs2276466 G allele frequencies were significantly higher in the glioma group than controls. Individuals with the rs1800067 GG genotype were at greater risk of glioma when compared with the A/A genotype in the codominant model, with an OR (95% CI) of 2.63 (1.04-7.25). The rs2276466 polymorphism was significantly associated with moderate increased risk of glioma in codominant and dominant models, with ORs (95% CI) of 1.90 (1.05-3.44) and 1.55 (1.07-2.47), respectively. The combination genotype of rs1800067 G and rs2276466 G alleles was associated with a reduced risk of glioma (OR=0.44, 95% CI=0.19-0.98). These findings indicate that genetic variants of the XPF gene have critical functions in the development of glioma.


Xeroderma pigmentosum complementation group F;single nucleotide polymorphisms;glioma


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