DOI QR코드

DOI QR Code

Xeroderma Pigmentosum Complementation Group F Polymorphisms Influence Risk of Glioma

  • Cheng, Hong-Bin ;
  • Xie, Chen ;
  • Zhang, Ru-You ;
  • Hu, Shao-Shan ;
  • Wang, Zhi ;
  • Yue, Wu
  • Published : 2013.07.30

Abstract

We conducted an exploratory investigation of whether variation in six common SNPs of xeroderma pigmentosum complementation group F (XPF) is associated with risk of glioma in a Chinese population. Six single nucleotide polymorphisms (SNPs) were genotyped in 207 glioma cases and 236 cancer-free controls by a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). The rs1800067 G and rs2276466 G allele frequencies were significantly higher in the glioma group than controls. Individuals with the rs1800067 GG genotype were at greater risk of glioma when compared with the A/A genotype in the codominant model, with an OR (95% CI) of 2.63 (1.04-7.25). The rs2276466 polymorphism was significantly associated with moderate increased risk of glioma in codominant and dominant models, with ORs (95% CI) of 1.90 (1.05-3.44) and 1.55 (1.07-2.47), respectively. The combination genotype of rs1800067 G and rs2276466 G alleles was associated with a reduced risk of glioma (OR=0.44, 95% CI=0.19-0.98). These findings indicate that genetic variants of the XPF gene have critical functions in the development of glioma.

Keywords

Xeroderma pigmentosum complementation group F;single nucleotide polymorphisms;glioma

References

  1. Bethke L, Webb E, Murray A, et al (2008). Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma. Hum Mol Genet, 17, 800-5.
  2. Blitzblau RC and Weidhaas JB (2010). MicroRNA binding-site polymorphisms as potential biomarkers of cancer risk. Mol Diagn Ther, 14, 335-42. https://doi.org/10.1007/BF03256390
  3. Bondy ML, Scheurer ME, Malmer B, et al (2008). Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer, 113, 1953-68. https://doi.org/10.1002/cncr.23741
  4. Chen DQ, Yao DX, Zhao HY, Yang SJ (2012). DNA repair gene ERCC1 and XPD polymorphisms predict glioma susceptibility and prognosis. Asian Pac J Cancer Prev, 13, 2791-4. https://doi.org/10.7314/APJCP.2012.13.6.2791
  5. Ding DP, He XF, Zhang Y (2011). Lack of association between XPG Asp1104His and XPF Arg415Gln polymorphism and breast cancer risk: a meta-analysis of case-control studies. Breast Cancer Res Treat, 129, 203-9. https://doi.org/10.1007/s10549-011-1447-9
  6. Doherty JA, Weiss NS, Fish S, et al (2011). Polymorphisms in Nucleotide Excision Repair Genes and Endometrial Cancer Risk. Cancer Epidemiol Biomarkers Prev, 20, 1873-82. https://doi.org/10.1158/1055-9965.EPI-11-0119
  7. Han J, Haiman C, Niu T, et al (2009). Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk. Breast Cancer Res Treat, 115, 613-22. https://doi.org/10.1007/s10549-008-0089-z
  8. He J, Xu Y, Qiu LX, et al (2012). Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population. PLoS One, 7, e49308. https://doi.org/10.1371/journal.pone.0049308
  9. Huang WY, Berndt SI, Kang D, et al. (2006). Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. Cancer Epidemiol Biomarkers Prev, 15, 306-11. https://doi.org/10.1158/1055-9965.EPI-05-0751
  10. Jacobs DI and Bracken MB (2012). Association between XRCC1 polymorphism 399 G- >A and glioma among Caucasians: a systematic review and meta-analysis. BMC Med Genet, 13, 97. https://doi.org/10.1186/1471-2350-13-97
  11. Knight JC (2005). Regulatory polymorphisms underlying complex disease traits. J Mol Med (Berl), 83, 97-109. https://doi.org/10.1007/s00109-004-0603-7
  12. Liu HB, Peng YP, Dou CW, et al (2012). Comprehensive study on associations between nine SNPs and glioma risk. Asian Pac J Cancer Prev, 13, 4905-8. https://doi.org/10.7314/APJCP.2012.13.10.4905
  13. Liu P, Siciliano J, White B, et al (1993). Regional mapping of human DNA excision repair gene ERCC4 to chromosome 16p13.13-p13.2. Mutagenesis, 8, 199-205. https://doi.org/10.1093/mutage/8.3.199
  14. Liu Z, Wei S, Ma H, et al (2011). A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck. Carcinogenesis, 32, 1668-74. https://doi.org/10.1093/carcin/bgr209
  15. Ostrom QT and Barnholtz-Sloan JS (2011). Current state of our knowledge on brain tumor epidemiology. Curr Neurol Neurosci Rep, 11, 329-35. https://doi.org/10.1007/s11910-011-0189-8
  16. Schwartzbaum JA, Fisher JL, Aldape KD, et al (2006). Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol, 2, 494-503.
  17. Tripsianes K, Folkers G, Ab E, et al (2005). The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair. Structure, 13, 1849-58. https://doi.org/10.1016/j.str.2005.08.014
  18. Pan WR, Li G, Guan JH (2013). Polymorphisms in DNA repair genes and susceptibility to glioma in a chinese population. Int J Mol Sci, 14, 3314-24. https://doi.org/10.3390/ijms14023314
  19. Pelletier C and Weidhaas JB (2010). MicroRNA binding site polymorphisms as biomarkers of cancer risk. Expert Rev Mol Diagn, 10, 817-29. https://doi.org/10.1586/erm.10.59
  20. Shete S, Hosking FJ, Robertson LB, et al (2009). Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet, 41, 899-904. https://doi.org/10.1038/ng.407
  21. Tsodikov OV, Enzlin JH, Scharer OD, Ellenberger T (2005). Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1. Proc Natl Acad Sci U S A, 102, 11236-41. https://doi.org/10.1073/pnas.0504341102
  22. Walsh KM, Anderson E, Hansen HM, et al (2013). Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidategene studies. Genet Epidemiol, 37, 222-8. https://doi.org/10.1002/gepi.21707
  23. Wang D, Hu Y, Gong H, Li J, Liu A (2012). Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: A case-control study. Gene, 509, 223-7. https://doi.org/10.1016/j.gene.2012.08.023
  24. Wood RD, Mitchell M, Sgouros J, Lindahl T (2001). Human DNA repair genes. Science, 291, 1284-9. https://doi.org/10.1126/science.1056154
  25. Wrensch M, Jenkins RB, Chang JS, et al (2009). Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet, 41, 905-8. https://doi.org/10.1038/ng.408
  26. Yu H, Liu Z, Huang YJ, et al (2012). Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck. PLoS One, 7, e41853. https://doi.org/10.1371/journal.pone.0041853

Cited by

  1. Associations of ERCC4 rs1800067 Polymorphism with Cancer Risk: an Updated Meta-analysis vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7639
  2. Association between the XPG Asp1104His and XPF Arg415Gln Polymorphisms and Risk of Cancer: A Meta-Analysis vol.9, pp.5, 2014, https://doi.org/10.1371/journal.pone.0088490
  3. A Comprehensive Analysis of Influence ERCC Polymorphisms Confer on the Development of Brain Tumors vol.53, pp.4, 2016, https://doi.org/10.1007/s12035-015-9371-3
  4. Polymorphisms in DNA Repair Gene and Susceptibility to Glioma: A Systematic Review and Meta-Analysis Based on 33 Studies with 15 SNPs in 9 Genes vol.37, pp.2, 2017, https://doi.org/10.1007/s10571-016-0367-y
  5. with Glioma in a Chinese Population vol.19, pp.1, 2015, https://doi.org/10.1089/gtmb.2014.0228